Search Result

Results for "

Depressant

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (10) AAK1 (1) Adenylate Cyclase (1) Adrenergic Receptor (8) Apoptosis (7) ATP Synthase (1) Autophagy (4) Bacterial (3) Bcl-2 Family (2) Calcium Channel (1) CDK (1) Cholinesterase (ChE) (3) CRFR (1) DNA/RNA Synthesis (2) Dopamine Receptor (1) Drug Derivative (6) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (2) Environmental Pollutants (1) Ephrin Receptor (1) Epigenetic Reader Domain (1) ERK (1) FGFR (1) Fungal (2) GABA Receptor (2) Guanylate Cyclase (1) HDAC (1) Histamine Receptor (6) HIV (2) iGluR (2) IRAK (1) Isotope-Labeled Compounds (3) Itk (1) LXR (1) MAP4K (1) MELK (1) mGluR (2) Mitosis (3) MMP (3) Monoamine Oxidase (3) Monoamine Transporter (1) mTOR (2) NF-κB (3) Opioid Receptor (2) P2X Receptor (2) p38 MAPK (1) Potassium Channel (1) PPAR (1) Prostaglandin Receptor (1) PROTACs (4) Ras (1) Reactive Oxygen Species (ROS) (1) Reference Standards (12) Reverse Transcriptase (2) Serotonin Transporter (3) Sodium Channel (1) Somatostatin Receptor (1) Trk Receptor (2) ULK (1) Vasopressin Receptor (1) Wee1 (1) Xanthine Oxidase (4) α-synuclein (3) β-glucuronidase (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (9) Infection (10) Inflammation/Immunology (17) Metabolic Disease (3) Neurological Disease (62)

By Targets:

5-HT Receptor (10)

AAK1 (1)

Adenylate Cyclase (1)

Adrenergic Receptor (8)

Apoptosis (7)

ATP Synthase (1)

Autophagy (4)

Bacterial (3)

Bcl-2 Family (2)

Calcium Channel (1)

CDK (1)

Cholinesterase (ChE) (3)

CRFR (1)

DNA/RNA Synthesis (2)

Dopamine Receptor (1)

Drug Derivative (6)

Drug Intermediate (1)

Drug Metabolite (1)

Endogenous Metabolite (2)

Environmental Pollutants (1)

Ephrin Receptor (1)

Epigenetic Reader Domain (1)

ERK (1)

FGFR (1)

Fungal (2)

GABA Receptor (2)

Guanylate Cyclase (1)

HDAC (1)

Histamine Receptor (6)

HIV (2)

iGluR (2)

IRAK (1)

Isotope-Labeled Compounds (3)

Itk (1)

LXR (1)

MAP4K (1)

MELK (1)

mGluR (2)

Mitosis (3)

MMP (3)

Monoamine Oxidase (3)

Monoamine Transporter (1)

mTOR (2)

NF-κB (3)

Opioid Receptor (2)

P2X Receptor (2)

p38 MAPK (1)

Potassium Channel (1)

PPAR (1)

Prostaglandin Receptor (1)

PROTACs (4)

Ras (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (12)

Reverse Transcriptase (2)

Serotonin Transporter (3)

Sodium Channel (1)

Somatostatin Receptor (1)

Trk Receptor (2)

ULK (1)

Vasopressin Receptor (1)

Wee1 (1)

Xanthine Oxidase (4)

α-synuclein (3)

β-glucuronidase (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (9)

Infection (10)

Inflammation/Immunology (17)

Metabolic Disease (3)

Neurological Disease (62)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0219

Allopurinol Maximum Cited Publications 12 Publications Verification	Xanthine Oxidase	Infection Neurological Disease Inflammation/Immunology Cancer
Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .

HY-B0478A

Trazodone 5+ Cited Publications AF-1161 free base	5-HT Receptor Serotonin Transporter Histamine Receptor Adrenergic Receptor	Neurological Disease
Trazodone (AF-1161 free base) is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). Trazodone has anti-depressant and anti-insomnious activity. Trazodone exerts antagonistic properties against a1- and a2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects .

HY-102064

SR 57227A 1 Publications Verification	5-HT Receptor	Neurological Disease
SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC₅₀) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects .

HY-107811

Harmol 1 Publications Verification	Autophagy α-synuclein Apoptosis Monoamine Oxidase Mitosis	Neurological Disease Cancer
Harmol is an orally active β-carboline alkaloid. Harmol is a TFEB activator and monoamine oxidase inhibitor. Harmol can induce cell mitosis, Autophagy and Apoptosis. Harmol promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol has anti-tumor, anti-depressant and anti-aging activities. Harmol improves motor impairment in a mouse Parkinson's disease model .

HY-108669

AZ10606120 dihydrochloride 2 Publications Verification	P2X Receptor	Neurological Disease Cancer
AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC₅₀ of about 10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth .

HY-B0478

Trazodone hydrochloride 5+ Cited Publications AF-1161	5-HT Receptor Serotonin Transporter Histamine Receptor Adrenergic Receptor	Neurological Disease
Trazodone hydrochloride (AF-1161) is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). Trazodone hydrochloride has anti-depressant and anti-insomnious activity. Trazodone hydrochloride exerts antagonistic properties against a1- and a2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects .

HY-B0219A

Allopurinol sodium Maximum Cited Publications 12 Publications Verification	Xanthine Oxidase	Infection Neurological Disease Inflammation/Immunology Cancer
Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .

HY-N6838

1,1,1,1-Kestohexaose 1,1,1,1-Kestohexose	Others	Others
1,1,1,1-Kestohexaose (1,1,1,1-Kestohexose) is an insulin-type fructooligosaccharide hexasaccharide. 1,1,1,1-Kestohexaose exhibits neuroprotective and anti-depressant-like activities. 1,1,1,1-Kestohexaose can alleviate Corticosteron (HY-B1618)-induced decrease in cell viability and NGF expression in vitro .

HY-148065

FMF-06-098-1	PROTACs Wee1 CDK AAK1 ULK MELK Itk IRAK Ephrin Receptor FGFR MAP4K p38 MAPK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .

HY-B0900

Anethole 2 Publications Verification Anise camphor; p-Propenylanisole; Isoestragole	Environmental Pollutants Apoptosis NF-κB Fungal Bacterial MMP	Infection Neurological Disease Inflammation/Immunology Cancer
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-N0165

Methyl-Hesperidin	HIV Reverse Transcriptase	Cardiovascular Disease Infection Inflammation/Immunology
Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .

HY-B0530

Azacyclonol 1 Publications Verification γ-pipradol	Histamine Receptor	Neurological Disease
Azacyclonol (γ-pipradol), a metabolite of Terfenadine, is a central depressant agent. Azacyclonol is a ganglion-blocking agent. Azacyclonol can be used to diminish psychoses-induced hallucinations .

HY-107790

5-Methoxyflavone 2 Publications Verification	DNA/RNA Synthesis	Neurological Disease
5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABA_A receptors.

HY-13999

Amdiglurax NSI-189	Trk Receptor	Neurological Disease
Amdiglurax (NSI-189) is an orally active chemical entity with enhanced neurogenic activity. Amdiglurax up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. Amdiglurax exhibits anti-depressant effect. Amdiglurax enhances synaptic plasticity and reduces cognitive dysfunction. Amdiglurax holds potential for psychiatric disorder research .

HY-N15574

Saringosterol	LXR Bacterial PPAR	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Saringosterol is an orally active steroid found in Sargassum muticum. Saringosterol is a LXR agonist. Saringosterol can lower cholesterol levels and inhibit the mRNA and protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding protein α (C/EBPα). Saringosterol has anti-obesity, anti-atherosclerosis, anti-Mycobacterium tuberculosis and anti-depressant activities .

HY-149878

BD-9136	PROTACs Epigenetic Reader Domain	Cancer
BD-9136 is a potent and highly selective BRD4 PROTAC depressant. BD-9136 has low-nanomolar degradation potencies against BRD4 , and its degradation selectivity for BRD4 is 1000 times that of BRD2 and BRD3 proteins. BD-9136 has antitumor activity .(Pink: Desmethyl-QCA276 (HY-44103); Black: 3-(2-(4-Methylpiperazin-1-yl)ethyl)azetidin-3-ol; Blue: Thalidomide-4-OH (HY-103596))

HY-109046

Tulrampator 2 Publications Verification CX-1632; S-47445	iGluR mTOR	Neurological Disease
Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder .

HY-203894

Carpipramine Defekton	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease
Carpipramine (Defekton) is an antipsychotic agent that belongs to the iminodibenzyl class. Carpipramine is a potent dopamine antagonist which blocks alpha 1- and alpha 2-adrenoceptors. Carpipramine also has antagonist properties with respect to serotonin (5-ΗΤ2) receptors. Carpipramine exhibits antipsychotic and anti-depressant effects. Carpipramine can be used for the research of neurological disease, such as post-traumatic stress disorder (PTSD) and depression .

HY-161410

WH244	PROTACs Apoptosis Bcl-2 Family	Cancer
WH244 is a second generation BCL-2 and BCL-xL dual depressant (PROTAC). The primary activity of WH244 is the specific degradation of BCL-2 and BCL-xL proteins (BCL-xL: DC₅₀=0.6 nM, BCL-2: DC₅₀=7.4 nM). WH244 promotes their ubiquitination and subsequent proteasome degradation by targeting these proteins, thereby restoring the cell's apoptosis pathway. WH244 has good antitumor activity. (Pink: BCL-2/BCL-xL ligand (HY-161415); Blue: E3 ligase ligand (HY-112078); Black: linker) .

HY-W294348

Prenderol 2,2-Diethyl-1,3-propanediol	Drug Derivative	Neurological Disease
Prenderol is a potent central-nervous-system depressant. Prenderol has anticonvulsant activity .

HY-P1212

Cortistatin 14 (mouse, rat) CST-14 (mouse, rat)	Somatostatin Receptor	Neurological Disease
Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus .

HY-117764

LSP4-2022	mGluR	Neurological Disease
LSP4-2022 is a potent and brain-penetrant mGlu4-selective orthosteric agonist, with an EC₅₀ of 0.11 μM. LSP4-2022 inhibits neurotransmission in cerebellar slices from wild-type but not mGlu4 receptor-knockout mice. LSP4-2022 shows pro-depressant activity .

HY-137951

Metizolam	Drug Derivative	Neurological Disease
Metizolam, a thienotriazolodiazepine, is the demethylated analogue of Etizolam. Metizolam exhibits psychomotor stabilizing, anxiolytic, sedative, myo-relaxant and amnestic effects .

HY-B0219R

Allopurinol (Standard)	Reference Standards Xanthine Oxidase	Infection Neurological Disease Inflammation/Immunology Cancer
Allopurinol (Standard) is the analytical standard of Allopurinol. This product is intended for research and analytical applications. Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .

HY-107750A

Cyprodime hydrochloride	Opioid Receptor	Neurological Disease
Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with K_i values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect .

HY-106769

Fluparoxan GR50360	Adrenergic Receptor	Neurological Disease
Fluparoxan is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan is an anti-depressant agent .

HY-106587A

Octoclothepin maleate salt Clorotepine maleate salt	Drug Derivative 5-HT Receptor	Neurological Disease
Octoclothepine (Clorotepine) maleate salt, an analog of Clozapine (HY-14539), is a neuroleptic and antipsychotic agent. Octoclothepine maleate salt exists in enantiomeric forms, where the (+)-form acts as an atypical antipsychotic, while the (-)-functions as a typical antipsychotic. (+)-Octoclothepine maleate salt exhibits extremely high binding affinity for 5-HT₆ and 5-HT₇ receptors, with K_i values of 0.41 and 0.38 nM; the K_i values of (-)-Octoclothepine maleate salt are 17.7 and 1.3 nM, respectively. Octoclothepine maleate salt can be used in research related to schizophrenia .

HY-W012618

1-Phenyl-1-propanol	Drug Intermediate	Neurological Disease
1-Phenyl-1-propanol is used as a chiral building block and synthetic intermediate in the pharmaceutical industries. 1-Phenyl-1-propanol is an intermediate of anti-depressant agent Fluoxetine (HY-B0102) .

HY-155352

mGluR5 antagonist-1	mGluR	Neurological Disease
mGluR5 antagonist-1 is an orally active mGluR5 antagonist with an IC₅₀ value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect. mGluR5 antagonist-1 can be used for the study of depressive disorder .

HY-13999A1

Amdiglurax phosphate NSI-189 phosphate	Trk Receptor	Neurological Disease
Amdiglurax (NSI-189) phosphate is an orally active chemical entity with enhanced neurogenic activity. Amdiglurax phosphate up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. Amdiglurax phosphate exhibits anti-depressant effect. Amdiglurax enhances synaptic plasticity and reduces cognitive dysfunction. Amdiglurax phosphate holds potential for psychiatric disorder research .

HY-B0219S1

Allopurinol-13C,15N2	Isotope-Labeled Compounds Xanthine Oxidase	Infection Neurological Disease Inflammation/Immunology Cancer
Allopurinol- ¹³C, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled labeled Allopurinol (HY-B0219). Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .

HY-U00149

Drobuline hydrochloride	Others	Cardiovascular Disease
Drobuline hydrochloride is an anti-arrhythmic agent with cardiac depressant.

HY-B1594

Carbromal Adalin; Adisomnol; Bromacetocarbamide	Others	Neurological Disease
Carbromal (Adalin; Adisomnol) is a sedative with centrally depressant effects .

HY-B0740S

Cyclobenzaprine-d3 hydrochloride MK130-d3 hydrochloride	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Cyclobenzaprine-d₃ (hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride. Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.

HY-W749797

Nitrazolam	GABA Receptor	Neurological Disease
Nitrazolam is a benzodiazepine compound, that may exhibit CNS depressant properties as traditional benzodiazepines, including sedation, hypnosis, anxiolysis, and anticonvulsant effects, by acting on GABA receptors .

HY-12132

DMP 904	CRFR Adenylate Cyclase	Neurological Disease
DMP 904 is a noncompetitive full corticotropin-releasing factor receptor (CRFR) antagonist. DMP 904 can inhibit CRF-stimulated adenylate cyclase activity and ACTH release. DMP 904 exhibits anti-depressant and anti-anxiety activity .

HY-137516A

LC-2 epimer	PROTACs Ras	Cancer
LC-2 epimer is a differential isomer of LC-2. LC-2 is a mutation-selective PROTAC depressant for KRAS and contains a ligand for the von Hippel Lindau E3 ligase linked to the KRAS inhibitor MRTX849 .

HY-106888

CS-722 Free base	Endogenous Metabolite	Neurological Disease
CS-722 Free base is a synthesized centrally acting muscle relaxant, and has a muscle relaxant activity and depressant effectson the spinal reflex . CS-722 Free base inhibits spontaneous inhibitory postsynaptic currents and excitatory postsynaptic currents in hippocampal cultures probably by an inhibition of both sodium and calcium currents .

HY-178573

V1b Receptor antagonist-1	Vasopressin Receptor	Neurological Disease
V1b receptor antagonist-1 is a potent, selective and brain-penetrant vasopressin 1b (V1b) receptor antagonist. V1b receptor antagonist-1 exhibits anti-depressant activity. V1b receptor antagonist-1 can be used for the research of neurological disease, such as depression .

HY-148038

5-HT3 antagonist 5	5-HT Receptor	Neurological Disease
5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT₃ receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT₃ agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice .

HY-167825

Barakol	MMP Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects .

HY-107811A

Harmol hydrochloride	Autophagy α-synuclein Apoptosis Monoamine Oxidase Mitosis	Neurological Disease Cancer
Harmol hydrochloride is an orally active β-carboline alkaloid. Harmol hydrochloride is a TFEB activator and monoamine oxidase inhibitor. Harmol hydrochloride can induce cell mitosis, Autophagy and Apoptosis. Harmol hydrochloride promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol hydrochloride has anti-tumor, anti-depressant and anti-aging activities. Harmol hydrochloride improves motor impairment in a mouse Parkinson's disease model .

HY-B0900R

Anethole (Standard) Anise camphor (Standard); p-Propenylanisole (Standard); Isoestragole (Standard)	Apoptosis Fungal Bacterial MMP NF-κB Reference Standards	Infection Neurological Disease Inflammation/Immunology Cancer
Anethole (Standard) is the analytical standard of Anethole. This product is intended for research and analytical applications. Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-N12121

Piperundecalidine	Others	Infection Inflammation/Immunology
Piperundecalidine is an amide alkaloids that can be purified from Piper longum L. Piperundecalidine shows various biological properties, such as anti-inammatory, analgesic, anti-amoebic, anti-depressant, hepatoprotective,etc. .

HY-136471

Anticonvulsant agent 6	Drug Derivative	Neurological Disease
Anticonvulsant agent 6 (Compound V) is a benzodiazepine compound with anticonvulsant and central depressant effects .

HY-B0530R

Azacyclonol (Standard) γ-pipradol (Standard)	Reference Standards Histamine Receptor	Neurological Disease
Azacyclonol (Standard) is the analytical standard of Azacyclonol. This product is intended for research and analytical applications. Azacyclonol (γ-pipradol), a metabolite of Terfenadine, is a central depressant agent. Azacyclonol is a ganglion-blocking agent. Azacyclonol can be used to diminish psychoses-induced hallucinations .

HY-N2109R

Macranthoidin A (Standard)	Reference Standards Others	Metabolic Disease
Macranthoidin A (Standard) is the analytical standard of Macranthoidin A. This product is intended for research and analytical applications. Macranthoidin A is an orally active saponin from Flos Lonicerae. Macranthoidin A possess protection effects on hepatic injury caused by Acetaminophen, Cd, and CCl4, and conspicuous depressant effects on swelling of ear croton oil .

HY-119795

Zometapine CI-781	Adrenergic Receptor	Neurological Disease
Zometapine (CI-781) is a pyrazolodiazepine derivative. Zometapine can be used in antidepressant research .

HY-107956

Imipramine pamoate	Monoamine Transporter	Neurological Disease
Imipramine pamoate is a potent anti-depressant compound .

HY-W687950

β-Phenyl GHB sodium	Drug Derivative	Neurological Disease
β-Phenyl GHB sodium is structurally similar to known CNS depressants.

Cat. No.	Product Name	Target	Research Area

HY-P1212

Cortistatin 14 (mouse, rat) CST-14 (mouse, rat)	Somatostatin Receptor	Neurological Disease
Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107811

Harmol 1 Publications Verification	Neurological Disease Classification of Application Fields Peganum harmala Linn. Pyridine Alkaloids Plants Endogenous metabolite Indole Alkaloids Alkaloids Monophenols Zygophyllaceae Phenols Disease Research Fields Source Classification	Autophagy α-synuclein Apoptosis Monoamine Oxidase Mitosis
Harmol is an orally active β-carboline alkaloid. Harmol is a TFEB activator and monoamine oxidase inhibitor. Harmol can induce cell mitosis, Autophagy and Apoptosis. Harmol promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol has anti-tumor, anti-depressant and anti-aging activities. Harmol improves motor impairment in a mouse Parkinson's disease model .

HY-N6838

1,1,1,1-Kestohexaose 1,1,1,1-Kestohexose	Polysaccharides other families Classification of Application Fields Other Diseases Plants Disease Research Fields Saccharides Source Classification	Others
1,1,1,1-Kestohexaose (1,1,1,1-Kestohexose) is an insulin-type fructooligosaccharide hexasaccharide. 1,1,1,1-Kestohexaose exhibits neuroprotective and anti-depressant-like activities. 1,1,1,1-Kestohexaose can alleviate Corticosteron (HY-B1618)-induced decrease in cell viability and NGF expression in vitro .

HY-B0900

Anethole 2 Publications Verification Anise camphor; p-Propenylanisole; Isoestragole	Structural Classification Classification of Application Fields Simple Phenylpropanols Leguminosae Phenylpropanoids Umbelliferae Plants Vernonia Schreb. Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	Environmental Pollutants Apoptosis NF-κB Fungal Bacterial MMP
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-N0165

Methyl-Hesperidin	Structural Classification Flavonoids other families Classification of Application Fields Flavonones Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	HIV Reverse Transcriptase
Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .

HY-N15574

Saringosterol	Structural Classification Marine algae Marine natural products Steroids Source Classification	LXR Bacterial PPAR
Saringosterol is an orally active steroid found in Sargassum muticum. Saringosterol is a LXR agonist. Saringosterol can lower cholesterol levels and inhibit the mRNA and protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding protein α (C/EBPα). Saringosterol has anti-obesity, anti-atherosclerosis, anti-Mycobacterium tuberculosis and anti-depressant activities .

HY-106888

CS-722 Free base	Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
CS-722 Free base is a synthesized centrally acting muscle relaxant, and has a muscle relaxant activity and depressant effectson the spinal reflex . CS-722 Free base inhibits spontaneous inhibitory postsynaptic currents and excitatory postsynaptic currents in hippocampal cultures probably by an inhibition of both sodium and calcium currents .

HY-167825

Barakol	Seeds of Cassia tora Linn. Natural Products Leguminosae Plants Source Classification	MMP Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects .

HY-B0900R

Anethole (Standard) Anise camphor (Standard); p-Propenylanisole (Standard); Isoestragole (Standard)	Structural Classification Simple Phenylpropanols Leguminosae Phenylpropanoids Umbelliferae Plants Vernonia Schreb. Glycyrrhiza uralensis Fisch. Source Classification	Apoptosis Fungal Bacterial MMP NF-κB Reference Standards
Anethole (Standard) is the analytical standard of Anethole. This product is intended for research and analytical applications. Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-N12121

Piperundecalidine	Piper longum Linn. Alkaloids Piperidine Alkaloids Piperaceae Plants Source Classification	Others
Piperundecalidine is an amide alkaloids that can be purified from Piper longum L. Piperundecalidine shows various biological properties, such as anti-inammatory, analgesic, anti-amoebic, anti-depressant, hepatoprotective,etc. .

HY-N2109R

Macranthoidin A (Standard)	Triterpenes Structural Classification Caprifoliaceae Terpenoids Plants Source Classification	Reference Standards Others
Macranthoidin A (Standard) is the analytical standard of Macranthoidin A. This product is intended for research and analytical applications. Macranthoidin A is an orally active saponin from Flos Lonicerae. Macranthoidin A possess protection effects on hepatic injury caused by Acetaminophen, Cd, and CCl4, and conspicuous depressant effects on swelling of ear croton oil .

HY-N3295

Mesuaxanthone A	Flavonoids Mesua ferrea L. Plants Calophyllaceae Other Flavonoids Source Classification	Others
Mesuaxanthone A is a xanthone with anti-inflammatory activities. Mesuaxanthone A shows typical CNS depressant effects .

HY-N3193

Neritaloside	Apocynaceae Structural Classification Nerium indicum Mill. Plants Steroids Source Classification	Others
Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect ^[2.

HY-107811R

Harmol (Standard)	Alkaloids Monophenols Zygophyllaceae Peganum harmala Linn. Phenols Pyridine Alkaloids Plants Endogenous metabolite Indole Alkaloids Source Classification	Apoptosis Monoamine Oxidase Autophagy α-synuclein Mitosis Reference Standards
Harmol (Standard) is the analytical standard of Harmol (HY-107811). This product is intended for research and analytical applications. Harmol hydrochloride is an orally active β-carboline alkaloid. Harmol hydrochloride is a TFEB activator and monoamine oxidase inhibitor. Harmol can induce cell mitosis, Autophagy and Apoptosis. Harmol promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol has anti-tumor, anti-depressant and anti-aging activities. Harmol improves motor impairment in a mouse Parkinson's disease model .

HY-N0165R

Methyl-Hesperidin (Standard)	Structural Classification Flavonoids other families Flavonones Phenols Polyphenols Plants Source Classification	Reference Standards HIV Reverse Transcriptase
Methyl-Hesperidin (Standard) is the analytical standard of Methyl-Hesperidin (HY-N0165). This product is intended for research and analytical applications. Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .

Cat. No.	Product Name	Chemical Structure

HY-B0219S1

Allopurinol-13C,15N2

Allopurinol- ¹³C, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled labeled Allopurinol (HY-B0219). Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .

HY-B0740S

Cyclobenzaprine-d3 hydrochloride
Cyclobenzaprine-d₃ (hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride. Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.

HY-100662S

Didesethyl chloroquine-d4
Didesethyl chloroquine-d₄ is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant .

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