Imipramine pamoate

Cat. No.: HY-107956: Data Sheet Handling Instructions
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Imipramine pamoate is a potent anti-depressant compound.

For research use only. We do not sell to patients.

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Other In-stock Forms of Imipramine pamoate:

Imipramine

Other Forms of Imipramine pamoate:

Imipramine In-stock

2 Publications Citing Use of MCE Imipramine pamoate

Cell Proliferation/Viability Assay

Cell Imaging/Staining

Cell Migration/Invasion Assay

Flow Cytometry

In Vivo Efficacy Study

IHC

: Imipramine pamoate purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 6:147:113969. [Abstract]; Cells were exposed to moclobemide, milnacipran, venlafaxine, escitalopram, amitriptyline, trazodone, fluvoxamine, or Imipramine (0–100 μM concentration) for 24 h. Cell viability was assessed with CCK-8 assays.

: Imipramine pamoate purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 6:147:113969. [Abstract]; CCK-8 assays for 24 h, 48 h and 72 h in KYSE30 and KYSE150 cells treated with various concentrations of Imipramine.

: Imipramine pamoate purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 6:147:113969. [Abstract]; Colony formation assays in KYSE30 and KYSE150 cells treated with Imipramine (0, 50, or 100 μM, 14 days) . Histograms represent the number of colonies per set of replicates, according to colony formation measurements (n = 3).

: Imipramine pamoate purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 6:147:113969. [Abstract]; Imipramine (0, 50, or 100 μM, 48 h). KYSE30 and KYSE150 cells showing migration or invasion in Transwell assays were fixed and stained. Cells that crossed the membranes were counted under a light microscope (10 × ) in three random fields of view.

: Imipramine pamoate purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 6:147:113969. [Abstract]; Imipramine (0, 50, or 100 μM, 48 h) induces apoptosis in ESCC cells. ESCC or HET-1A cells were treated with various concentrations of Imipramine for 48 h. Cell apoptosis was detected by flow cytometry with annexin V-FITC/Caspase-3 double staining.

: Imipramine pamoate purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 6:147:113969. [Abstract]; ESCC cells were treated with various concentrations of Imipramine (50, 100 μM) for 48 h. Western blotting was performed to assess Bax, Bcl-2, and cleaved-caspase-3 expression.

: Imipramine pamoate purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 6:147:113969. [Abstract]; Anti-tumor effect of Imipramine (receiving intraperitoneal injections of 20 mg/kg/day, 15 days) in a xenograft model.Representative images depicting the appearance of tumors at the conclusion of treatment. Tumor volumes were measured every 3 days. Final tumor weights.

: Imipramine pamoate purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 6:147:113969. [Abstract]; Imipramine (receiving intraperitoneal injections of 20 mg/kg/day, 15 days). Expression of P62, ATG5-ATG12 complex, Bcl-2, Bax, and Ki-67 was detected by IHC staining in tumor tissues.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Imipramine pamoate is a potent anti-depressant compound^[1]^[2].

Clinical Trial

Molecular Weight

949.18

Formula

C₆₁H₆₄N₄O₆

CAS No.

10075-24-8

SMILES

OC1=C(C2=CC=CC=C2C=C1C(O)=O)CC3=C(O)C(C(O)=O)=CC4=CC=CC=C34.CN(C)CCCN5C6=CC=CC=C6CCC7=C5C=CC=C7.CN(C)CCCN8C9=CC=CC=C9CCC%10=C8C=CC=C%10

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Doyle LN. Imipramine pamoate in depression. Psychosomatics. 1975;16(3):129-31. [Content Brief]

[2]. Goldberg HL, et al. Which tricyclic for depressed outpatients, imipramine pamoate or amitriptyline? Dis Nerv Syst. 1977 Oct;38(10):785-9. [Content Brief]