5-HT3 antagonist 5
Based on 1 Customer Validation
5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice.
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 901599-43-7
- Formula: C16H13N3O2
- Molecular Weight:279.29
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
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5-HT3 Receptor |
5-HT3 antagonist 5 (compound 4c) exhibits 5-HT3 receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methyl-5-HT, with pA2 value of 5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino mice (23 ± 2 g)[1]
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Dosage:1 mg/kg
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Administration:Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration
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Result:Reduced the duration of immobility as compared to the vehicle-treated (control) group.
Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity.
Chemical Information
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CAS No. 901599-43-7
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Appearance Solid
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Molecular Weight 279.29
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Formula C16H13N3O2
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Color Light yellow to yellow
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SMILES
O=C(C1=NC2=CC=CC=C2N=C1)NC3=CC=C(C=C3)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 20.83 mg/mL (74.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5805 mL | 17.9025 mL | 35.8051 mL | 89.5127 mL |
| 5 mM | 0.7161 mL | 3.5805 mL | 7.1610 mL | 17.9025 mL | |
| 10 mM | 0.3581 mL | 1.7903 mL | 3.5805 mL | 8.9513 mL | |
| 15 mM | 0.2387 mL | 1.1935 mL | 2.3870 mL | 5.9675 mL | |
| 20 mM | 0.1790 mL | 0.8951 mL | 1.7903 mL | 4.4756 mL | |
| 25 mM | 0.1432 mL | 0.7161 mL | 1.4322 mL | 3.5805 mL | |
| 30 mM | 0.1194 mL | 0.5968 mL | 1.1935 mL | 2.9838 mL | |
| 40 mM | 0.0895 mL | 0.4476 mL | 0.8951 mL | 2.2378 mL | |
| 50 mM | 0.0716 mL | 0.3581 mL | 0.7161 mL | 1.7903 mL | |
| 60 mM | 0.0597 mL | 0.2984 mL | 0.5968 mL | 1.4919 mL |
5-HT3 antagonist 5 Related Classifications
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