1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Cyprodime hydrochloride

Cyprodime hydrochloride 

Cat. No.: HY-107750A
Handling Instructions

Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with Ki values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect.

For research use only. We do not sell to patients.

Cyprodime hydrochloride Chemical Structure

Cyprodime hydrochloride Chemical Structure

CAS No. : 2387505-50-0

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Description

Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with Ki values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect[1][2].

IC50 & Target

Ki: 5.4 nM (μ-opioid), 244.6 nM (δ-opioid) and 2187 nM (κ-opioid)[1]

In Vitro

Cyprodime hydrochloride has Ki values of 8.1 nM and 26.6 nM for μ-opioid receptor in rat brain (Wistar) and guinea pig brain[1].

In Vivo

Cyprodime hydrochloride (3, 10 mg/kg; i.p.; 60 min prior to test) significantly increases immobility time in the forced swimming test (FST) with higher dose of 10 mg/kg. Cyprodime hydrochloride increases the grooming time[2].

Animal Model: Male NMRI mice aged 21-25 days and weighing 10-12 g[2]
Dosage: 3, 10 mg/kg
Administration: IP; 60 min prior to test
Result: Significantly increased immobility time in the forced swimming test (FST) with higher dose of 10 mg/kg.
Molecular Weight

391.93

Formula

C₂₂H₃₀ClNO₃

CAS No.

2387505-50-0

SMILES

CO[[email protected]@]12[[email protected]]3(CC(CC2)=O)C4=C(OC)C=CC=C4C[[email protected]@]1([H])N(CC5CC5)CC3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CyprodimeOpioid Receptoranti-depressantimmobilitytimeforcedswimmingdepressantInhibitorinhibitorinhibit

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Cyprodime hydrochloride
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HY-107750A
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