Cyprodime hydrochloride
Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with Ki values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect.
For research use only. We do not sell to patients.
- CAS No.: 2387505-50-0
- Formula: C22H30ClNO3
- Molecular Weight:391.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Ki: 5.4 nM (μ-opioid), 244.6 nM (δ-opioid) and 2187 nM (κ-opioid)[1]
Cyprodime hydrochloride has Ki values of 8.1 nM and 26.6 nM for μ-opioid receptor in rat brain (Wistar) and guinea pig brain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male NMRI mice aged 21-25 days and weighing 10-12 g[2]
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Dosage:3, 10 mg/kg
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Administration:IP; 60 min prior to test
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Result:Significantly increased immobility time in the forced swimming test (FST) with higher dose of 10 mg/kg.
Chemical Information
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CAS No. 2387505-50-0
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Molecular Weight 391.93
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Formula C22H30ClNO3
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SMILES
CO[C@@]12[C@]3(CC(CC2)=O)C4=C(OC)C=CC=C4C[C@@]1([H])N(CC5CC5)CC3.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Márki A, et al. Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays. Eur J Pharmacol. 1999 Oct 27;383(2):209-14. [Content Brief]
[2]. Haj-Mirzaian A, et al. Involvement of opioid system in behavioral despair induced by social isolation stress in mice. Biomed Pharmacother. 2019 Jan;109:938-944. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyprodime hydrochloride Related Classifications
HY-107750A Related Classifications
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