2387505-50-0
2387505-50-0
Chemical Structure
Cyprodime hydrochloride
- CAS No.: 2387505-50-0
- Formula:C22H30ClNO3
- Molecular Weight:391.93
IUPAC Name: (4bR,8aS,9R)-11-(cyclopropylmethyl)-4,8a-dimethoxy-8,8a,9,10-tetrahydro-5H-9,4b-(epiminoethano)phenanthren-6(7H)-one hydrochloride
InChIKey: MMOBYZBXXHEAAX-NCBCLDNOSA-N
SMILES: CO[C@@]12[C@]3(CC(CC2)=O)C4=C(OC)C=CC=C4C[C@@]1([H])N(CC5CC5)CC3.Cl
Biological Activity: Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with Ki values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect[1][2].
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Cyprodime hydrochloride | Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with Ki values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect. | |||||||||||||||||||||
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References
- [1]. Márki A, et al. Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays. Eur J Pharmacol. 1999 Oct 27;383(2):209-14. [Content Brief]
- [2]. Haj-Mirzaian A, et al. Involvement of opioid system in behavioral despair induced by social isolation stress in mice. Biomed Pharmacother. 2019 Jan;109:938-944. [Content Brief]
Keywords
