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Cat. No.: HY-178573

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V1b Receptor antagonist-1

V1b receptor antagonist-1 is a potent, selective and brain-penetrant vasopressin 1b (V1b) receptor antagonist. V1b receptor antagonist-1 exhibits anti-depressant activity. V1b receptor antagonist-1 can be used for the research of neurological disease, such as depression.

For research use only. We do not sell to patients.

CAS No.: 1056550-56-1
Formula: C₃₆H₃₂N₆O₅S
Molecular Weight:660.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

V1b Receptor antagonist-1 Chemical Structure

CAS No.: 1056550-56-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

V1b Receptor

All Vasopressin Receptor Isoforms :

In Vivo

V1b receptor antagonist-1 (Compound 9c) (0.3-3 mg/kg, i.p.) shows anti-depressant activity in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Depressant rats models^[1]
Dosage:

0.3, 1 and 3 mg/kg
Administration:

Intraperitoneally injection
Result:

Increased latency to immobility in the forced swimming test.

Chemical Information

CAS No. 1056550-56-1
Molecular Weight 660.74
Formula C₃₆H₃₂N₆O₅S
SMILES

N#CC1=CC=C2C(C(C3=CC(OC)=CC=C3OCC)(N4CCN(CC4)C5=CC=NC=C5)C(N2S(=O)(C6=CC=CC7=CC=CN=C76)=O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Geneste H, et al. Novel, potent, selective and brain penetrant vasopressin 1b receptor antagonists. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3260-3264. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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