Barakol
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects.
For research use only. We do not sell to patients.
- CAS No.: 24506-68-1
- Formula: C13H12O4
- Molecular Weight:232.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C8166 | CC50 |
73.42 μg/mL
Compound: 15
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Cytotoxicity against human C8166 cells by MTT assay
Cytotoxicity against human C8166 cells by MTT assay
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[PMID: 23078294] |
| C8166 | EC50 |
4.28 μg/mL
Compound: 15
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Antiviral activity against HIV1 infected in human C8166 cells assessed as inhibition of virus-induced cytopathic effect
Antiviral activity against HIV1 infected in human C8166 cells assessed as inhibition of virus-induced cytopathic effect
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[PMID: 23078294] |
Chemical Information
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CAS No. 24506-68-1
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Molecular Weight 232.23
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Formula C13H12O4
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SMILES
OC1=CC2=C3C(OC(C)=CC(OC(C)=C2)3O)=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Thongsaard W, et al. Barakol: a potential anxiolytic extracted from Cassia siamea. Pharmacol Biochem Behav. 1996 Mar;53(3):753-8. [Content Brief]
[2]. Wongsawatkul O, et al. Effects of barakol from Cassia siamea on neuroblastoma SH-SY5Y cell line: A potential combined therapy with doxorubicin. Heliyon. 2024 Jan 19;10(3):e24694. [Content Brief]
[3]. Wongtongtair S, et al. Barakol-induced apoptosis in P19 cells through generation of reactive oxygen species and activation of caspase-9. J Ethnopharmacol. 2011 Sep 2;137(2):971-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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