24506-68-1
Chemical Structure
Barakol
- CAS No.: 24506-68-1
- Formula:C13H12O4
- Molecular Weight:232.23
InChIKey: LVPNMZHEDIKUFK-UHFFFAOYSA-N
SMILES: OC1=CC2=C3C(OC(C)=CC(OC(C)=C2)3O)=C1
Biological Activity: Barakol is an anticancer and anxiolytic agent identified in Cassia siamea. Barakol inhibits MMP-3 activity and enhances the cytotoxicity and antimetastatic effects of Doxorubicin (HY-15142) against cancer cells. Barakol induces apoptosis via reactive oxygen species (ROS) production, upregulation of the Bax/Bcl-2 protein ratio, and activation of caspase-9. Barakol exerts anxiolytic activity with diazepam-like effects, increases spontaneous longitudinal smooth muscle contraction of rat ileum in a concentration-dependent manner (EC50 = 0.3 mM), and inhibits norepinephrine-induced contraction suppression. Barakol can be used in research related to anxiety, intestinal motility, and neuroblastoma[1][2][3][4].
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Barakol | Barakol is an anticancer and anxiolytic agent identified in Cassia siamea. Barakol inhibits MMP-3 activity and enhances the cytotoxicity and antimetastatic effects of Doxorubicin (HY-15142) against cancer cells. Barakol induces apoptosis via reactive oxygen species (ROS) production, upregulation of the Bax/Bcl-2 protein ratio, and activation of caspase-9. Barakol exerts anxiolytic activity with diazepam-like effects, increases spontaneous longitudinal smooth muscle contraction of rat ileum in a concentration-dependent manner (EC50 = 0.3 mM), and inhibits norepinephrine-induced contraction suppression. Barakol can be used in research related to anxiety, intestinal motility, and neuroblastoma. | |||||||||||||||||||||
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References
- [1]. Wongtongtair S, et al. Barakol-induced apoptosis in P19 cells through generation of reactive oxygen species and activation of caspase-9. Journal of ethnopharmacology. 2011 Sep 02;137(2):971-8. [Content Brief]
- [2]. Wongsawatkul O, et al. Effects of barakol from Cassia siamea on neuroblastoma SH-SY5Y cell line: A potential combined therapy with doxorubicin. Heliyon. 2024 Jan 19;10(3):e24694. [Content Brief]
- [3]. Thongsaard W, et al. Barakol: a potential anxiolytic extracted from Cassia siamea. Pharmacology, biochemistry, and behavior. 1996 Mar;53(3):753-8. [Content Brief]
- [4]. Deachapunya C, et al. Barakol suppresses norepinephrine-induced inhibition of spontaneous longitudinal smooth muscle contractions in isolated rat small intestine. Journal of ethnopharmacology. 2005 Oct 03;101(1-3):227-32.
