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Hexokinase

" in MedChemExpress (MCE) Product Catalog:

標的別:	Glucokinase (3) Hexokinase (26) AMPK (1) Antibiotic (1) Apoptosis (11) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Drug Derivative (1) Endogenous Metabolite (3) Glucose-6-Phosphate Isomerase (GPI) (2) GLUT (1) HSV (5) Isotope-Labeled Compounds (6) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) Mitophagy (1) Parasite (3) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Small Interfering RNA (siRNA) (1) VDAC (1)
研究分野別:	Cancer (21) Infection (2) Inflammation/Immunology (4) Metabolic Disease (10) Neurological Disease (4)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

阻害剤およびアゴニスト

スクリーニングライブラリ

ペプチド

天然物

組換えタンパク質

同位体標識化合物

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オリゴヌクレオチド

Targets Recommended: Hexokinase Glucokinase

製品番号	製品名	Target	研究分野	構造式

HY-13966

2-Deoxy-D-glucose 340+ Cited Publications 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose	Hexokinase HSV Apoptosis	Cancer
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-19992

3-Bromopyruvic acid 30+ Cited Publications Bromopyruvic acid; 3-BrPA; Hexokinase II Inhibitor II, 3-BP	Hexokinase Apoptosis Autophagy	Cancer
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities .

HY-B0486

Lonidamine 15+ Cited Publications AF-1890; Diclondazolic Acid; DICA	Hexokinase Mitochondrial Metabolism Apoptosis Parasite	Inflammation/Immunology Cancer
Lonidamine (AF-1890) is a *hexokinase* and mitochondrial pyruvate carrier inhibitor (K_i: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis .

HY-134929

Benitrobenrazide 2 Publications Verification BNBZ; Hexokinase 2 inhibitor 1	Hexokinase Apoptosis	Cancer
Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC₅₀ of 0.53 µM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect .

HY-155008

PROTAC HK2 Degrader-1 2 Publications Verification	PROTACs Hexokinase	Cancer
PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research .

HY-U00462

D-Mannoheptulose	Hexokinase	Metabolic Disease Cancer
D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by *hexokinase* isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-P2776A

Hexokinase, Yeast	Endogenous Metabolite	Others
Hexokinase, Yeast catalyzes the phosphorylation of glucose, and is involved in glycolysis. Hexokinase, Yeast participates is also related to energy production, protection of mitochondrial integrity, and cell survival .

HY-19843

MK-0941	Glucokinase	Metabolic Disease
MK-0941 is a selective, orally active, and allosteric glucokinase activator with EC₅₀s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 activates hexokinase subtype IV. MK-0941 can increase insulin secretion and glucose uptake. MK-0941 can be studied in research for type 2 diabetes .

HY-175035

HK-2-IN-1	Hexokinase	Inflammation/Immunology Cancer
HK-2-IN-1 is a Hexokinase 2 (HK-2) inhibitor. HK-2-IN-1 exhibits a non-activating effect on human recombinant HK-2 enzyme. HK-2-IN-1 has anti-tumor activity, affecting immune cells in the tumor microenvironment. HK-2-IN-1 has immunomodulatory effects and is potentially useful in the study of cancers such as colon cancer, liver cancer, and breast cancer .

HY-P2776

Hexokinase, microorganism	Endogenous Metabolite	Metabolic Disease
Hexokinase (ScHEX1) (EC 2.7.1.1) is a glycolytic enzyme hexokinase that is inhibited by n-acetylglucosamine. Inhibition of Hexokinase (ScHEX1) by n-acetylglucosamine leads to its separation from the mitochondrial outer membrane, resulting in activation of NLRP3 inflammasome .

HY-139409A

2-Deoxy-D-glucose 6-phosphate disodium 2 Publications Verification	Hexokinase Glucose-6-Phosphate Isomerase (GPI)	Cancer
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive *Hexokinase* inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research .

HY-P10108

Hexokinase II VDAC binding domain peptide, cell-permeable Hxk2VBD peptide, cell-permeable	Hexokinase	Neurological Disease
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth .

HY-13966S

2-Deoxy-D-glucose-d1 1 Publications Verification 2-DG-d₁; 2-Deoxy-D-arabino-hexose-d₁; D-Arabino-2-deoxyhexose-d₁	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-B0486R

Lonidamine (Standard) AF-1890 (Standard); Diclondazolic Acid (Standard); DICA (Standard)	Reference Standards Hexokinase Mitochondrial Metabolism Apoptosis Parasite	Inflammation/Immunology Cancer
Lonidamine (Standard) is the analytical standard of Lonidamine. This product is intended for research and analytical applications. Lonidamine (AF-1890) is a *hexokinase* and mitochondrial pyruvate carrier inhibitor (K_i: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis .

HY-W000133

Metrizamide Amipaque	Hexokinase	Neurological Disease
Metrizamide (Amipaque) is used as the contrast medium for angiography in neuroradiological investigations . Metrizamide inhibits human brain hexokinase .

HY-111331

Germicidin B	Antibiotic Hexokinase Bacterial	Infection
Germicidin B is an antibiotic with bactericidal activity. Germicidin B inhibits *hexokinase* II with an IC₅₀ of 25.16 μM. Germicidin B suppresses spore germination in Streptomyces. Germicidin B is applicable to studies on bacterial infections .

HY-13966S2

2-Deoxy-D-glucose-13C 2-DG-¹³C; 2-Deoxy-D-arabino-hexose-¹³C; D-Arabino-2-deoxyhexose-¹³C	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose- ¹³C is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-169728

SID 24785302	Hexokinase Parasite	Infection
SID 24785302 is a *hexokinase* inhibitor with antiparasitic activity. SID 24785302 exhibits activity against T. brucei and Leishmania. SID 24785302 can be used for the research of mitochondrial DNA disorders and parasitic infection .

HY-168717

HK-2-IN-2	Hexokinase Microtubule/Tubulin Reactive Oxygen Species (ROS)	Cancer
HK2-IN-2 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC₅₀ value of 0.764 μM against MD-MBA-231 cells. HK2-IN-2 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle .

HY-P2776B

Hexokinase, Bacillus sp.	Endogenous Metabolite	Others
Hexokinase, Bacillus sp. catalyzes the phosphorylation of glucose, and is involved in glycolysis. Hexokinase, Bacillus sp. participates is also related to energy production, protection of mitochondrial integrity, and cell survival .

HY-139409

2-Deoxy-D-glucose 6-phosphate	Hexokinase Glucose-6-Phosphate Isomerase (GPI)	Cancer
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive and 2-deoxy-D-glucose non-competitive *Hexokinase* inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the generation and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research .

HY-13966S4

2-Deoxy-D-glucose-13C-1 2-DG-¹³C-1; 2-Deoxy-D-arabino-hexose-¹³C-1; D-Arabino-2-deoxyhexose-¹³C-1	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose- ¹³C-1 is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-13966S3

2-Deoxy-D-glucose-13C6 2-DG-¹³C₆; 2-Deoxy-D-arabino-hexose-¹³C₆; D-Arabino-2-deoxyhexose-¹³C₆	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose- ¹³C₆ (2-DG- ¹³C₆) is ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-RS06192

HK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HK1 Human Pre-designed siRNA Set A contains three designed siRNAs for HK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HK1 Human Pre-designed siRNA Set A HK1 Human Pre-designed siRNA Set A

HY-P3257B

ADP-Specific glucokinase, thermococcus litoralis ADP-Dependent Hexokinase, thermococcus litoralis	Glucokinase	Neurological Disease Metabolic Disease Cancer
ADP-Specific glucokinase, thermococcus litoralis is an ADP-specific glucose kinase expressed in thermophilic archaea. ADP-Specific glucokinase, thermococcus litoralis can catalyze glucose into glucose-6-phosphate, which promotes glycolysis. ADP-Specific glucokinase, thermococcus litoralis can activate T cells and enhance the phagocytic activity of macrophages. ADP-Specific glucokinase, thermococcus litoralis can be used in research on metabolic diseases, neurological disorders, and tumors .

HY-P3257A

ADP-specific glucokinase, pyrococcus furiosus ADP-dependent Hexokinase, pyrococcus furiosus	Glucokinase	Neurological Disease Metabolic Disease Cancer
ADP-Specific glucokinase, pyrococcus furiosus is an ADP-specific glucose kinase expressed in thermophilic archaea. ADP-Specific glucokinase, pyrococcus furiosus can catalyze glucose into glucose-6-phosphate, which promotes glycolysis. ADP-Specific glucokinase, pyrococcus furiosus can activate T cells and enhance the phagocytic activity of macrophages. ADP-Specific glucokinase, pyrococcus furiosus can be used in research on metabolic diseases, neurological disorders, and tumors .

HY-W767186

D-Mannoheptulose-13C7	Isotope-Labeled Compounds Hexokinase	Metabolic Disease Cancer
D-Mannoheptulose- ¹³C₇ is the ¹³C-labeled D-Mannoheptulose. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-U00462S

D-Mannoheptulose-13C	Isotope-Labeled Compounds Hexokinase	Metabolic Disease Cancer
D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose (HY-U00462) . D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by *hexokinase* isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-P2776C

Hexokinase, Saccharomyces cerevisiae	Hexokinase	Metabolic Disease
Hexokinase, Saccharomyces cerevisiae (EC 2.7.1.1), is a naturally occurring Saccharomyces cerevisiae hexokinase used in studies of glucose metabolism and enzymatic mechanisms.

HY-P2776D

Hexokinase, Rhodothermus obamensis	Hexokinase	Metabolic Disease
Hexokinase, Rhodothermus obamensis (EC 2.7.1.1), is a naturally occurring Saccharomyces cerevisiae hexokinase used in studies of glucose metabolism and enzymatic mechanisms.

HY-180805

HK2-IN-3	Hexokinase Mitophagy Apoptosis GLUT	Cancer
HK2-IN-3 (compound 12) is a potent hexokinase 2 (HK2) inhibitor with an IC₅₀ of 56.4 nM. HK2-IN-3 reduces glucose uptake and downregulated GLUT1/GLUT4 in oral squamous cell carcinoma (OSCC). HK2-IN-3 induces mitophagy and apoptosis. HK2-IN-3 suppresses tumor growth and angiogenesis in OSCC xenograft mouse models. HK2-IN-3 can be used for OSCC research .

HY-183809

ZSW	Hexokinase	Inflammation/Immunology
ZSW is a hexokinase 2 (HK2) inhibitor with human HK2 IC₅₀ of 0.48 μM, human HK2 K_a of 252.00 μM, and selectivity over HK3 and GCK. ZSW binds directly to HK2, inhibits its enzymatic activity, modulates macrophage phenotypes through glycolysis inhibition, and inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation and degradation. ZSW alleviates inflammatory bowel disease (IBD) and improves the intestinal inflammatory state of IBD mice. ZSW can be used for the research of inflammatory bowel disease .

HY-P2776E

Hexokinase, Kluyveromyces fragilis

HY-139409B

2-Deoxy-D-glucose 6-phosphate sodium	Drug Derivative	Metabolic Disease
2-Deoxy-D-glucose 6-phosphate sodium, a derivative of 2-Deoxy-D-glucose (HY-13966), is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-182243

HK2-IN-4	Hexokinase VDAC Apoptosis AMPK Bcl-2 Family	Cancer
HK2-IN-4 is a selective hexokinase 2 (HK2) inhibitor with an IC₅₀ value of 0.79 μM and a K_d value of 0.41 μM. HK2-IN-4 blocks the interaction between HK2 and voltage-dependent anion channel 1 (VDAC1). HK2-IN-4 reduces lactate and ATP levels in cancer cells. HK2-IN-4 induces the production of apoptosis (apoptosis) markers in cancer cells, including increased p-AMPK/AMPK ratio and Bax levels, as well as decreased Bcl2 levels. HK2-IN-4 inhibits the proliferation of cancer cells with high HK2 expression. HK2-IN-4 can be used in research related to colorectal cancer and non-small cell lung cancer .

製品番号	製品名

HY-L058

Glycolysis Compound Library	1,258 compounds
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation. Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications. MCE provides a unique collection of 1,258 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Glycolysis Compound Library

1,258 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 1,258 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

HY-L092

Glucose Metabolism Compound Library	1,652 compounds
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer. MCE offers a unique collection of 1,652 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

Glucose Metabolism Compound Library

1,652 compounds

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer.

MCE offers a unique collection of 1,652 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

HY-L009

Kinase Inhibitor Library	3,849 compounds
Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders. Kinase inhibitor library designed by MCE contains 3,849 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

Kinase Inhibitor Library

3,849 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 3,849 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

製品番号	製品名	Target	研究分野

HY-P10108

Hexokinase II VDAC binding domain peptide, cell-permeable Hxk2VBD peptide, cell-permeable	Hexokinase	Neurological Disease
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth .

製品番号	製品名	Category	Target	構造式

HY-13966

2-Deoxy-D-glucose 340+ Cited Publications 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose	Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Source Classification Cancer	Hexokinase HSV Apoptosis
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-U00462

D-Mannoheptulose	Persea americana Mill Classification of Application Fields Metabolic Disease Plants Lauraceae Disease Research Fields Saccharides Monosaccharides Source Classification	Hexokinase
D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by *hexokinase* isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-111331

Germicidin B	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Hexokinase Bacterial
Germicidin B is an antibiotic with bactericidal activity. Germicidin B inhibits *hexokinase* II with an IC₅₀ of 25.16 μM. Germicidin B suppresses spore germination in Streptomyces. Germicidin B is applicable to studies on bacterial infections .

Species:	Human (7) Mouse (1)
Tag:	His (7) Tag Free (1) GST (1)
Source:	P. pastoris (2) Sf9 insect cells (4) E. coli (2)

製品番号	Compare	製品名	Species	Source	Image

HY-P700580

	*HK1/Hexokinase-1 Protein, Human (His)* Hexokinase-1; HK1; Brain form Hexokinase; Hexokinase type I; HK I; Hexokinase-A	Human	E. coli
	The HK1/hexokinase-1 protein phosphorylates hexose sugars, including D-glucose, D-glucosamine, D-fructose, D-mannose, and 2-deoxy-D-glucose, to form the corresponding hexose 6-phosphate. HK1/Hexokinase-1 Protein, Human (His) is the recombinant human-derived HK1/Hexokinase-1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703943

	HK2 Protein, Human (sf9, His) Hexokinase-2; Hexokinase type II; Hexokinase-B; Muscle form Hexokinase	Human	Sf9 insect cells
	HK2 Protein, Human (sf9, His) is the recombinant human-derived HK2 protein, expressed by Sf9 insect cells, with C-10*His tag.

HY-P700581

	*HK1/Hexokinase-1 Protein, Human (P. pastoris, His)* Hexokinase-1; HK1; Brain form Hexokinase; Hexokinase type I; HK I; Hexokinase-A	Human	P. pastoris
	The HK1/hexokinase-1 protein phosphorylates hexose sugars, including D-glucose, D-glucosamine, D-fructose, D-mannose, and 2-deoxy-D-glucose, to form the corresponding hexose 6-phosphate. HK1/Hexokinase-1 Protein, Human (P. pastoris, His) is the recombinant human-derived HK1/Hexokinase-1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P703943Y

	HK2 Protein, Human (sf9, His, solution) Hexokinase-2; Hexokinase type II; Hexokinase-B; Muscle form Hexokinase	Human	Sf9 insect cells
	HK2 Protein, Human (sf9, His, solution) is the recombinant human-derived HK2 protein, expressed by Sf9 insect cells, with C-10*His tag.

HY-P74881

	*HK3/Hexokinase-3 Protein, Human (sf9, His-GST)* Hexokinase-3; HK III; Hexokinase-C; HK3	Human	Sf9 insect cells
	The HK3 (hexokinase-3) protein promotes the phosphorylation of hexoses (i.e., D-glucose and D-fructose) to form hexose-6-phosphate (specifically, D-glucose 6-phosphate and 6-phosphate), Plays a vital role in cell metabolism. D-fructose 6-phosphate. HK3/Hexokinase-3 Protein, Human (sf9, His-GST) is the recombinant human-derived HK3/Hexokinase-3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P75790

	Glucokinase/GCK Protein, Human Hexokinase-4; HK4; Hexokinase-D; Glucokinase	Human	E. coli
	Glucokinase/GCK proteins catalyze hexose phosphorylation, converting D-glucose, D-fructose, and D-mannose into their respective hexose 6-phosphates. Glucokinase/GCK Protein, Human is the recombinant human-derived Glucokinase/GCK protein, expressed by E. coli , with tag free.

HY-P704013

	HK2 Protein, Mouse (sf9, His) Hexokinase-2; Hexokinase type II; Hk2 ;	Mouse	Sf9 insect cells
	HK2 Protein, Mouse (sf9, His) is the recombinant mouse-derived HK2 protein, expressed by Sf9 insect cells, with C-His tag.

HY-P71822

	GCKR Protein, Human (P.pastoris, His) FGQTL5; GCK ; GLRE; Glucokinase regulatory protein; Hexokinase 4 regulator; Hexokinase-D; HK IV; HK4	Human	P. pastoris
	The GCKR protein plays a critical regulatory role in glucokinase (GCK) by forming an inactive complex and recruiting GCK to the nucleus after meals. Its interaction with GCK is finely tuned by fructose metabolites; binding of GCKR to fructose-6-phosphate increases the affinity for GCK, whereas binding to fructose-1-phosphate decreases the affinity, thereby releasing inhibition. GCKR Protein, Human (P.pastoris, His) is the recombinant human-derived GCKR protein, expressed by P. pastoris , with N-His labeled tag.

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製品番号	製品名	構造式

HY-13966S

2-Deoxy-D-glucose-d1 1 Publications Verification
2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-13966S2

2-Deoxy-D-glucose-13C
2-Deoxy-D-glucose- ¹³C is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-13966S4

2-Deoxy-D-glucose-13C-1
2-Deoxy-D-glucose- ¹³C-1 is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-13966S3

2-Deoxy-D-glucose-13C6
2-Deoxy-D-glucose- ¹³C₆ (2-DG- ¹³C₆) is ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-W767186

D-Mannoheptulose-13C7

D-Mannoheptulose- ¹³C₇ is the ¹³C-labeled D-Mannoheptulose. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-U00462S

D-Mannoheptulose-13C

D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose (HY-U00462) . D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

Host:	Mouse (9) Rabbit (6)
Reactivity:	Human (15) Rat (11) Mouse (9) Rabbit (2) Hamster (2)
Application:	IHC-P (8) ICC/IF (4) IP (5) WB (15) FC (5) ELISA (7)
Isotype:	IgG (5) IgG1 (6) IgG,IgG/Kappa (1)
Conjugation:	Non-conjugated (15)
Clonality:	Monoclonal (10) Recombinant (3)
Modification:	Unmodified (10)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P80702

	Hexokinase I Antibody (YA739) HK1; Hexokinase-1; Brain form Hexokinase; Hexokinase type I; HK I	WB	Human, Mouse, Rat
	Hexokinase I Antibody (YA739) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase I.

HY-P86604

	Hexokinase II Antibody (YA6296) HK2; Hexokinase-2; Hexokinase type II; HK II; Muscle form Hexokinase	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Hexokinase II Antibody (YA6296) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hexokinase II.

HY-P85209

	Hexokinase I Antibody (YA4901) HK1; Hexokinase-1; Brain form Hexokinase; Hexokinase type I; HK I	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	Hexokinase I Antibody (YA4901) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hexokinase I.

HY-P80702A

	Hexokinase I Antibody (YA739)(PBS only) HK1; Hexokinase-1; Brain form Hexokinase; Hexokinase type I; HK I	WB	Human, Mouse, Rat
	Hexokinase I Antibody (YA739) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase I.

HY-P82295

	Glucokinase Antibody (YA2040) GCK; Glucokinase; Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D	WB	Human
	Glucokinase Antibody (YA2040) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucokinase.

HY-P85184

	Glucokinase Antibody (YA4876) GCK; Glucokinase; Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D	WB, ELISA	Human
	Glucokinase Antibody (YA4876) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Glucokinase.

HY-P85528

	Hexokinase I Antibody (YA5220) BB404130; Brain form Hexokinase; dea; Glycolytic enzyme; HEXOKIN; Hexokinase PI; Hexokinase type I; Hexokinase, tumor isozyme; Hexokinase-1; Hexokinase-A; HK I; HK1; HK1 tb; Hk1-s; HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1; HXK1_HUMAN; mHk1-s.	WB	Human, Mouse, Rat
	Hexokinase I Antibody (YA5220) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hexokinase I.

HY-P80703

	Hexokinase II Antibody (YA386) HKII; HXK2	WB, IHC-P, IP	Human, Rat, Hamster
	Hexokinase II Antibody (YA386) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hexokinase II.

HY-P80703A

	Hexokinase II Antibody (YA386)(PBS only) HKII; HXK2	WB, IHC-P, IP	Human, Rat, Hamster
	Hexokinase II Antibody (YA386) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hexokinase II.

HY-P83243

	HKDC1 Antibody (YA2988) Hexokinase domain-containing protein 1	WB, IP	Human
	HKDC1 Antibody (YA2988) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HKDC1.

HY-P84385

	Hexokinase II Antibody (YA4082) HKII; HXK2; DKFZp686M1669; HK2	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit
	Hexokinase II Antibody (YA4082) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase II.

HY-P83243A

	HKDC1 Antibody (YA2988)(PBS only) Hexokinase domain-containing protein 1	WB, IP	Human
	HKDC1 Antibody (YA2988) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HKDC1.

HY-P84385A

	Hexokinase II Antibody (YA4082)(PBS only) HKII; HXK2; DKFZp686M1669; HK2	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit
	Hexokinase II Antibody (YA4082) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase II.

HY-P84156

	Hexokinase I Antibody (YA3853) HKI; HXK1; HK1-ta; HK1-tb; HK1-tc; HK1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	Hexokinase I Antibody (YA3853) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase I.

HY-P84156A

	Hexokinase I Antibody (YA3853)(PBS only) HKI; HXK1; HK1-ta; HK1-tb; HK1-tc; HK1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	Hexokinase I Antibody (YA3853) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase I.

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