HK-2-IN-2
HK2-IN-2 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC50 value of 0.764 μM against MD-MBA-231 cells. HK2-IN-2 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle.
For research use only. We do not sell to patients.
- CAS No.: 3056278-80-6
- Formula: C26H22N4O6S
- Molecular Weight:518.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Hexokinase 2 |
Chemical Information
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CAS No. 3056278-80-6
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Molecular Weight 518.54
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Formula C26H22N4O6S
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SMILES
O=C(C1=CC=CN=C1)/C=C/C2=CN(S(=O)(C3=CC=C([N+]([O-])=O)C=C3)=O)C4=C2C=C(N5CCOCC5)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)