HK-2-IN-2
HK2-IN-2 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC50 value of 0.764 μM against MD-MBA-231 cells. HK2-IN-2 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle.
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- CAS No.: 3056278-80-6
- 화학식: C26H22N4O6S
- 분자량:518.54
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Hexokinase 2 |
Chemical Information
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CAS No. 3056278-80-6
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분자량 518.54
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화학식 C26H22N4O6S
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SMILES
O=C(C1=CC=CN=C1)/C=C/C2=CN(S(=O)(C3=CC=C([N+]([O-])=O)C=C3)=O)C4=C2C=C(N5CCOCC5)C=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)