HK2-IN-3
HK2-IN-3 (compound 12) is a potent hexokinase 2 (HK2) inhibitor with an IC50 of 56.4 nM. HK2-IN-3 reduces glucose uptake and downregulated GLUT1/GLUT4 in oral squamous cell carcinoma (OSCC). HK2-IN-3 induces mitophagy and apoptosis. HK2-IN-3 suppresses tumor growth and angiogenesis in OSCC xenograft mouse models. HK2-IN-3 can be used for OSCC research.
For research use only. We do not sell to patients.
- CAS No.: 2679261-30-2
- Formula: C15H11N3O4S
- Molecular Weight:329.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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GLUT1 |
GLUT4 |
HK2 56.4 nM (IC50) |
Chemical Information
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CAS No. 2679261-30-2
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Molecular Weight 329.33
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Formula C15H11N3O4S
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SMILES
O=C(N/N=C/C1=C(O)C(O)=C(O)C=C1)C(S2)=NC3=C2C=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)