2. Metabolic Enzyme/Protease Autophagy Apoptosis Membrane Transporter/Ion Channel
  3. Hexokinase Mitophagy Apoptosis GLUT
  4. HK2-IN-3

HK2-IN-3 (compound 12) is a potent hexokinase 2 (HK2) inhibitor with an IC50 of 56.4 nM. HK2-IN-3 reduces glucose uptake and downregulated GLUT1/GLUT4 in oral squamous cell carcinoma (OSCC). HK2-IN-3 induces mitophagy and apoptosis. HK2-IN-3 suppresses tumor growth and angiogenesis in OSCC xenograft mouse models. HK2-IN-3 can be used for OSCC research.

For research use only. We do not sell to patients.

HK2-IN-3

HK2-IN-3 Chemical Structure

CAS No. : 2679261-30-2

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HK2-IN-3 Related Antibodies

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Description

HK2-IN-3 (compound 12) is a potent hexokinase 2 (HK2) inhibitor with an IC50 of 56.4 nM. HK2-IN-3 reduces glucose uptake and downregulated GLUT1/GLUT4 in oral squamous cell carcinoma (OSCC). HK2-IN-3 induces mitophagy and apoptosis. HK2-IN-3 suppresses tumor growth and angiogenesis in OSCC xenograft mouse models. HK2-IN-3 can be used for OSCC research[1].

IC50 & Target[1]

GLUT1

 

GLUT4

 

HK2

56.4 nM (IC50)

Molecular Weight

329.33

Formula

C15H11N3O4S
CAS No.
SMILES

O=C(N/N=C/C1=C(O)C(O)=C(O)C=C1)C(S2)=NC3=C2C=CC=C3
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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HK2-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HK2-IN-32679261-30-2HexokinaseMitophagyApoptosisGLUTMitochondrial AutophagyGlucose transporterhexokinaseoral squamous cell carcinomaangiogenesismitophagyCal27 cellsFaDu cellsInhibitorinhibitorinhibit

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