2679261-30-2
2679261-30-2
Chemical Structure
HK2-IN-3
- CAS No.: 2679261-30-2
- Formula:C15H11N3O4S
- Molecular Weight:329.33
InChIKey: WXQLONDGSYPXEF-FRKPEAEDSA-N
SMILES: O=C(N/N=C/C1=C(O)C(O)=C(O)C=C1)C(S2)=NC3=C2C=CC=C3
Biological Activity: HK2-IN-3 (compound 12) is a potent hexokinase 2 (HK2) inhibitor with an IC50 of 56.4 nM. HK2-IN-3 reduces glucose uptake and downregulated GLUT1/GLUT4 in oral squamous cell carcinoma (OSCC). HK2-IN-3 induces mitophagy and apoptosis. HK2-IN-3 suppresses tumor growth and angiogenesis in OSCC xenograft mouse models. HK2-IN-3 can be used for OSCC research[1].
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HK2-IN-3 | HK2-IN-3 (compound 12) is a potent hexokinase 2 (HK2) inhibitor with an IC50 of 56.4 nM. HK2-IN-3 reduces glucose uptake and downregulated GLUT1/GLUT4 in oral squamous cell carcinoma (OSCC). HK2-IN-3 induces mitophagy and apoptosis. HK2-IN-3 suppresses tumor growth and angiogenesis in OSCC xenograft mouse models. HK2-IN-3 can be used for OSCC research. | |||||||||||||||||||||
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References
Keywords
