2. Metabolic Enzyme/Protease
  3. Hexokinase
  4. ZSW

ZSW is a hexokinase 2 (HK2) inhibitor with human HK2 IC50 of 0.48 μM, human HK2 Ka of 252.00 μM, and selectivity over HK3 and GCK. ZSW binds directly to HK2, inhibits its enzymatic activity, modulates macrophage phenotypes through glycolysis inhibition, and inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation and degradation. ZSW alleviates inflammatory bowel disease (IBD) and improves the intestinal inflammatory state of IBD mice. ZSW can be used for the research of inflammatory bowel disease.

For research use only. We do not sell to patients.

ZSW

ZSW Chemical Structure

CAS No. : 3124329-46-7

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ZSW Related Antibodies

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Description

ZSW is a hexokinase 2 (HK2) inhibitor with human HK2 IC50 of 0.48 μM, human HK2 Ka of 252.00 μM, and selectivity over HK3 and GCK. ZSW binds directly to HK2, inhibits its enzymatic activity, modulates macrophage phenotypes through glycolysis inhibition, and inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation and degradation. ZSW alleviates inflammatory bowel disease (IBD) and improves the intestinal inflammatory state of IBD mice. ZSW can be used for the research of inflammatory bowel disease[1].

In Vitro

ZSW (0.5-1 μM; 24 h) dose-dependently inhibits LPS-induced pro-inflammatory cytokine IL-1β and IL-6 gene expression in RAW264.7 mouse macrophages after 24 h co-treatment with 0.5 or 1 μM ZSW[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZSW Related Antibodies

Real Time qPCR[1]

Cell Line: LPS-stimulated RAW264.7 mouse macrophages
Concentration: 0.5-1 μM
Incubation Time: 24 h
Result: Significantly reduced LPS-induced upregulation of IL-1β mRNA levels in a dose-dependent manner.
Significantly reduced LPS-induced upregulation of IL-6 mRNA levels in a dose-dependent manner.
In Vivo

ZSW (10-30 mg/kg; i.p.; daily; 9 days) significantly alleviates DSS (HY-116282C)-induced acute colitis in male C57BL/6J mice by reducing weight loss, improving colon length, lowering DAI scores, restoring colonic histology, modulating inflammatory cytokine expression, and exhibiting a favorable safety profile[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 7 weeks old, 20-25 g, DSS-induced acute colitis)[1]
Dosage: 10 mg/kg; 20 mg/kg; 30 mg/kg
Administration: i.p.; daily; 9 days
Result: Maintained higher body weights than the DSS-only group at study end.
Increased colon length compared to the DSS-only group, with partial restoration toward control levels.
Reduced disease activity index (DAI) scores compared to the DSS-only group.
Improved colonic epithelial integrity, reduced ulceration, preserved goblet cells, and restored organized crypt structure relative to the DSS-only group.
Downregulated splenic iNOS mRNA expression compared to the DSS-only group, with the 20 mg/kg dose showing the strongest reduction.
Suppressed colonic pro-inflammatory IL-1β mRNA expression and upregulated anti-inflammatory IL-10 and Arg-1 mRNA expression compared to the DSS-only group.
Showed no significant differences in spleen, kidney, or liver indices relative to controls, with no obvious liver or kidney toxicity observed via H&E staining.
Molecular Weight

518.54

Formula

C26H22N4O6S
CAS No.
SMILES

O=C(C1=CN=CC=C1)/C=C/C2=CN(C3=CC=C(C=C23)N4CCOCC4)S(=O)(C5=CC=CC=C5[N+]([O-])=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZSW Related Classifications

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZSW3124329-46-7Hexokinaseinflammatory bowel diseaseIκBαRAW264.7 mouse macrophagesNF-κBHK3C57BL/6J micemacrophagesHK2hexokinase 2GCKInhibitorinhibitorinhibit

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