3124329-46-7
Chemical Structure
ZSW
- CAS No.: 3124329-46-7
- Formula:C26H22N4O6S
- Molecular Weight:518.54
InChIKey: ZDMVHBJBWIFHPG-JXMROGBWSA-N
SMILES: O=C(C1=CN=CC=C1)/C=C/C2=CN(C3=CC=C(C=C23)N4CCOCC4)S(=O)(C5=CC=CC=C5[N+]([O-])=O)=O
Biological Activity: ZSW is a hexokinase 2 (HK2) inhibitor with human HK2 IC50 of 0.48 μM, human HK2 Ka of 252.00 μM, and selectivity over HK3 and GCK. ZSW binds directly to HK2, inhibits its enzymatic activity, modulates macrophage phenotypes through glycolysis inhibition, and inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation and degradation. ZSW alleviates inflammatory bowel disease (IBD) and improves the intestinal inflammatory state of IBD mice. ZSW can be used for the research of inflammatory bowel disease[1].
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ZSW | ZSW is a hexokinase 2 (HK2) inhibitor with human HK2 IC50 of 0.48 μM, human HK2 Ka of 252.00 μM, and selectivity over HK3 and GCK. ZSW binds directly to HK2, inhibits its enzymatic activity, modulates macrophage phenotypes through glycolysis inhibition, and inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation and degradation. ZSW alleviates inflammatory bowel disease (IBD) and improves the intestinal inflammatory state of IBD mice. ZSW can be used for the research of inflammatory bowel disease. | |||||||||||||||||||||
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Keywords
