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Results for "

TMPRSS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TMPRSS6 (5) Androgen Receptor (3) Apoptosis (2) Autophagy (3) Bcl-2 Family (1) c-Myc (1) Casein Kinase (1) Cathepsin (1) CDK (1) DNA/RNA Synthesis (1) EGFR (1) Endogenous Metabolite (2) Factor Xa (2) Hepcidin (1) HIV (3) HSP (1) Influenza Virus (2) Isotope-Labeled Compounds (1) Molecular Glues (1) PAI-1 (1) Parasite (1) Pim (1) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) SARS-CoV (25) Ser/Thr Protease (24) Small Interfering RNA (siRNA) (27) Thrombin (1) Virus Protease (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (5) Endocrinology (1) Infection (25) Inflammation/Immunology (6) Metabolic Disease (9) Neurological Disease (1)
Click Chemistry:	PROTAC Synthesis (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (7) Mouse Pre-designed siRNA Sets (7) siRNA drugs (2) Human Pre-designed siRNA Sets (11) Antisense Oligonucleotides (2) siRNAs (27)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: TMPRSS6 Enteropeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13512

Camostat mesylate 40+ Cited Publications Camostat mesilate; FOY305; FOY-S980	Ser/Thr Protease SARS-CoV	Infection Inflammation/Immunology
Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of *TMPRSS2, shows antiviral activity against SARS-CoV-2*. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

HY-B0372A

Bromhexine hydrochloride 3 Publications Verification	SARS-CoV Autophagy HIV	Metabolic Disease
Bromhexine hydrochloride is a potent and specific *TMPRSS2* protease inhibitor with an IC₅₀ of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions .

HY-114402

ARD-69	PROTACs Androgen Receptor	Cancer
ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor, which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells. ARD-69 inhibits AR-regulated gene expression, binds to the AR ligand binding domain at one end and binds to VHL at the other end, prompting AR to be recruited to the E3 ubiquitin ligase complex, triggering proteasome degradation, thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA, TMPRSS2). ARD-69 can be used to study of castration-resistant prostate cancer (mCRPC) . ARD-69 is composed of a target protein ligand (pink part) AR antagonist 14 (HY-172624), a PROTAC linker (black part) tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and a VHL-type E3 ubiquitinase ligand (blue part) VH 101, acid (HY-47070); among them, the VHL ligand and the linker can form a conjugate VH 101-amide-piperidine-Pip-alkyne (HY-172625).

HY-134432B

Boc-Gln-Ala-Arg-AMC acetate 1 Publications Verification	Ser/Thr Protease	Others
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .

HY-P2990

Enteropeptidase TMPRSS15	Ser/Thr Protease	Metabolic Disease
Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .

HY-177662

Sapablursen IONIS-TMPRSS6-Lrx; ISIS 702843	TMPRSS6	Metabolic Disease
Sapablursen, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen can be used in the research of blood diseases such as pol

HY-148072

MM3122	SARS-CoV	Infection
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC₅₀ value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells .

HY-108447

BC-11 hydrobromide	Ser/Thr Protease SARS-CoV PAI-1	Infection Cancer
BC-11 hydrobromide is a selective *TMPRSS2* inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC₅₀=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer .

HY-W195509

Debrisoquin hydroiodide Debrisoquine hydroiodide; Isocaramidine hydroiodide; Ro 5-3307/1 hydroiodide	SARS-CoV Ser/Thr Protease	Infection
Debrisoquin (hydroiodide) is the hydrochloride form of Debrisoquin (HY-B1624). Debrisoquin is a *TMPRSS2* inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner. Debrisoquin can be used for antiviral research .

HY-B1624A

Debrisoquin hemisulfate Debrisoquine hemisulfate; Isocaramidine hemisulfate; Ro 5-3307/1 hemisulfate	Endogenous Metabolite	Infection Cardiovascular Disease
Debrisoquin (Isocaramidine) hemisulfate is a *TMPRSS2* inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC₅₀ of 22μM. Debrisoquin hemisulfate can be used for antiviral research .

HY-130136A

TMPRSS6-IN-1 TFA	Ser/Thr Protease	Others
TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). *TMPRSS6*, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .

HY-W749874

Qingdainone 1 Publications Verification	Ser/Thr Protease	Inflammation/Immunology Cancer
Qingdainone is a quinazoline alkaloid and also a *TMPRSS2* inhibitor. Qingdainone can be isolated from Strobilanthes cusia. Qingdainone exhibits anti-tumor and anti-inflammatory activities. Qingdainone can be used in studies related to chronic myeloid leukemia .

HY-13512R

Camostat mesylate (Standard) Camostat mesilate (Standard); FOY305 (Standard); FOY-S980 (Standard)	Reference Standards Ser/Thr Protease SARS-CoV	Infection Inflammation/Immunology
Camostat (mesylate) (Standard) is the analytical standard of Camostat (mesylate). This product is intended for research and analytical applications. Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of *TMPRSS2, shows antiviral activity against SARS-CoV-2*. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

HY-147278

Manusiran Divesiran; SLN124	Ser/Thr Protease Small Interfering RNA (siRNA) TMPRSS6	Cardiovascular Disease
Manusiran (Divesiran) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran increases hepatic Hepcidin synthesis and plasma levels by silencing *TMPRSS6*, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia .

HY-130136

TMPRSS6-IN-1	Ser/Thr Protease	Others
TMPRSS6-IN-1 (compound 8) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). *TMPRSS6*, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .

HY-177662A

Sapablursen sodium IONIS-TMPRSS6-Lrx sodium; ISIS 702843 sodium	TMPRSS6	Metabolic Disease
Sapablursen sodium, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen sodium can be used in the research of blood diseas

HY-B1624

Debrisoquin Debrisoquine; Isocaramidine; Ro 5-3307/1	SARS-CoV Ser/Thr Protease	Infection Cardiovascular Disease
Debrisoquin (Isocaramidine) is a *TMPRSS2* inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC₅₀ of 22μM. Debrisoquin can be used for antiviral research .

HY-130402B

Propamidine	Parasite	Infection
Propamidine is a covalent inhibitor of TMPRSS2 and has some antibacterial activity. .

HY-P11260

MD5	Ser/Thr Protease Thrombin	Metabolic Disease
MD5 is a selective *TMPRSS6* mimetic peptide inhibitor with an IC₅₀ for recombinant human TMPRSS6 protein of 22 nM and a K_i of 3.4 nM. MD5 exhibits the significantly reduced inhibitory effect on Matriptase, with an IC₅₀ of 352 nM and a K_i of 99.2 nM. MD5 exhibits good target specificity and only has a weak inhibitory effect on thrombin (Thrombin), with K_i of 120 nM. MD5 demonstrates good initial drugability and can be used for the study of iron overload diseases (such as hereditary hemochromatosis, β-thalassemia) .

HY-169250

TMPRSS13-IN-1	Ser/Thr Protease	Cancer
TMPRSS13-IN-1 (N-0430) is a potent *TMPRSS13* inhibitor with a K_i of 25 nM .

HY-147278A

Manusiran sodium Divesiran sodium; SLN124 sodium	Ser/Thr Protease Small Interfering RNA (siRNA) TMPRSS6	Others
Manusiran (SLN124) sodium, a GalNAc conjugated 19-mer siRNA targeting *TMPRSS6* (transmembrane protease serine 6), reduces plasma iron and increases hepcidin levels ^[1][2].

HY-158073

ML2006a4	SARS-CoV	Infection
ML2006a4 is an orally active inhibitor for SARS-CoV-2 main protease (M ^pro) with IC₅₀ in picomolare value. ML2006a4 is cell permeable and antiviral active, that inhibits replication in SARS-CoV-2 in cells Huh7.5.1-ACE2-TMPRSS2 (Huh7.5.1++) in picomolare level

HY-134432A

Boc-Gln-Ala-Arg-AMC hydrochloride	Ser/Thr Protease	Others
Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2 .

HY-174350

CK2-IN-15	Casein Kinase SARS-CoV	Infection
CK2-IN-15 (Compound Biv5) is a selective and potent bivalent protein kinase CK2 inhibitor with an IC₅₀ value of 51 pM. CK2-IN-15 significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also reduces viral replication in an ex vivo model of human nasal epithelial cells. CK2-IN-15 is promising for research of β-coronavirus infection-related diseases .

HY-B0372AS

Bromhexine-d3 hydrochloride	Isotope-Labeled Compounds SARS-CoV Autophagy HIV	Metabolic Disease
Bromhexine-d₃ (hydrochloride) is deuterium labeled Bromhexine (hydrochloride). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC₅₀ of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions .

HY-161902

MI-1904	Ser/Thr Protease Influenza Virus SARS-CoV	Infection
MI-1904 is the inhibitor for *matriptase/TMPRSS2, that exhibits antiviral activity against influenza virus* H1N1 and H9N2. MI-1904 blocks the cleavage of glycoproteins on the viral surface, prevents the virus from binding to host cell receptors, and thus inhibits the entry and replication of the virus .

HY-161370

VD4162	Ser/Thr Protease	Cancer
VD4162 (Compound 8b) is a macrocyclic inhibitor of serine proteases. VD4162 can significantly improve potency for all four target enzymes TMPRSS2 (IC₅₀ = 3.7 nM), HGFA(IC₅₀ = 3.3 nM), matriptase (IC₅₀ = 2.9 nM), and hepsin (IC₅₀ = 0.54 nM). VD4162 can be used for the research of cancer .

HY-B0372AR

Bromhexine hydrochloride (Standard)	Reference Standards SARS-CoV Autophagy HIV	Metabolic Disease
Bromhexine (hydrochloride) (Standard) is the analytical standard of Bromhexine (hydrochloride). This product is intended for research and analytical applications. Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions .

HY-163029

CTSL/B-IN-1	Cathepsin SARS-CoV	Infection
CTSLCTSB-IN-1 (compound 212-148) is a bispecific inhibitor of host viral spike cleaver proteins CTSL/CTSB and *TMPRSS2* with IC₅₀s of 2.13/64.07 nM and 1.38 μM, respectively. CTSLCTSB-IN-1 blocks two relevant SARS-CoV-2 viral entry pathways by inhibiting the viral spike cleavage and can be applied to anti-SARS-CoV-2 research .

HY-173148

TKB272	SARS-CoV	Infection
TKB272 is an orally active and selective antiviral agent targeting the main protease (Mpro) of SARS-CoV-2. It effectively blocks the infection and replication of various SARS-CoV-2 strains, including Omicron variants such as XBB.1.5 and EG.5.1. The enzymatic inhibitory activity of TKB272 shows an IC₅₀ of 0.7 µM (against SARS-CoV-2WK-521 Mpro), and its antiviral activity at the cellular level reaches an EC₅₀ as low as 2.6 nM (against BQ.1.1 strain in HeLahACE2-TMPRSS2 cells), with a cytotoxicity CC₅₀ of 98 µM, indicating no apparent toxicity. In addition, TKB272 significantly suppresses the replication of SARS-CoV-2XBB.1.5 in B6.Cg-Tg(K18-hACE2)2-Prlmn/J transgenic mouse models. TKB272 holds promise for research in the field of SARS-CoV-2 infection .

HY-179123

ZC9	Androgen Receptor Apoptosis	Cancer
ZC9 is a novel androgen receptor (AR) degrader. ZC9 directly binds to AR and inhibits Dihydrotestosterone-induced nuclear translocation of AR. ZC9 promotes AR degradation via the ubiquitin-proteasome system and suppresses AR transcriptional activity. ZC9 significantly decreases the mRNA levels of other AR downstream genes, including PSA, *TMPRSS2, and PMEPA1. ZC9 promotes Apoptosis*. ZC9 exhibits anticancer activity against prostate cancer .

HY-175344

TMP1	SARS-CoV Virus Protease Ser/Thr Protease	Infection Inflammation/Immunology
TMP1 is an orally active bispecific inhibitor of M pro (IC₅₀ = 312.5 nM)/TMPRSS2 (IC₅₀ = 1.28 μM, K_D = 10.10 μM). TMP1 exhibits broad protection against different SARS-CoV-2 variants in vitro. TMP1 cross-protects against highly pathogenic coronaviruses (SARS-CoV-1, SARS-CoV-2, and MERS-CoV) in vivo and effectively blocks the transmission of SARS-CoV-2. TMP1 can inhibit infection by SARS-CoV-2 escape mutants that are resistant to Nivolumab (HY-P9903). TMP1 can be used in coronavirus research .

HY-170820

XYD049	Molecular Glues Bcl-2 Family CDK EGFR HSP Androgen Receptor c-Myc	Cancer
XYD049 is a CRBN-based molecular glue degrader targeting GSPT1, with a DC₅₀ of 19 nM. XYD049 mediates the formation of a ternary complex between CRBN and GSPT1, thereby triggering CRBN- and proteasome-dependent degradation of GSPT1. By degrading GSPT1, XYD049 downregulates castration-resistant prostate cancer (CRPC)-related oncogenes, including BCL2, CDK2, E2F3, EGFR, HSP90B1, *TMPRSS2, AR, AR-V7, PSA* and c-Myc. XYD049 inhibits cancer cell growth and suppresses tumor growth in mice. XYD049 can be used for research on castration-resistant prostate cancer. XYD049 consists of a linker (black part) NH2-C5-NH-Boc (HY-W004710), a CRBN-based E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a target protein ligand (red part) GSPT1 ligand-1 (HY-170821), among which the E3 ligase ligand plus linker forms the conjugate E3 Ligase Ligand-linker Conjugate 158 (HY-170822) .

HY-P990524

*Anti-TMPRSS2 Antibody*	Ser/Thr Protease	Inflammation/Immunology
The Anti-TMPRSS2 Antibody is a CHO-expressed humanized antibody that targets *TMPRSS2. The Anti-TMPRSS2 Antibody features a huIgG1 heavy chain and a huκ light chain, with an expected molecular weight (MW) of 150 kDa. For the isotype control of the Anti-TMPRSS*2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-RS14768

TMPRSS15 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMPRSS15 Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMPRSS15 Human Pre-designed siRNA Set A TMPRSS15 Human Pre-designed siRNA Set A

HY-RS14770

TMPRSS3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMPRSS3 Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMPRSS3 Human Pre-designed siRNA Set A TMPRSS3 Human Pre-designed siRNA Set A

HY-RS21279

Tmprss15 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tmprss15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tmprss15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tmprss15 Mouse Pre-designed siRNA Set A Tmprss15 Mouse Pre-designed siRNA Set A

HY-RS16739

Tmprss2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tmprss2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tmprss2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tmprss2 Mouse Pre-designed siRNA Set A Tmprss2 Mouse Pre-designed siRNA Set A

HY-RS14772

TMPRSS5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMPRSS5 Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMPRSS5 Human Pre-designed siRNA Set A TMPRSS5 Human Pre-designed siRNA Set A

HY-RS19286

Tmprss6 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tmprss6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tmprss6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tmprss6 Mouse Pre-designed siRNA Set A Tmprss6 Mouse Pre-designed siRNA Set A

HY-RS24924

Tmprss4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tmprss4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tmprss4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tmprss4 Rat Pre-designed siRNA Set A Tmprss4 Rat Pre-designed siRNA Set A

HY-RS14769

TMPRSS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMPRSS2 Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMPRSS2 Human Pre-designed siRNA Set A TMPRSS2 Human Pre-designed siRNA Set A

HY-RS27798

Tmprss15 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tmprss15 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tmprss15 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tmprss15 Rat Pre-designed siRNA Set A Tmprss15 Rat Pre-designed siRNA Set A

HY-RS14771

TMPRSS4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMPRSS4 Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMPRSS4 Human Pre-designed siRNA Set A TMPRSS4 Human Pre-designed siRNA Set A

HY-RS14763

TMPRSS11A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMPRSS11A Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS11A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMPRSS11A Human Pre-designed siRNA Set A TMPRSS11A Human Pre-designed siRNA Set A

HY-RS14765

TMPRSS11D Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMPRSS11D Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS11D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMPRSS11D Human Pre-designed siRNA Set A TMPRSS11D Human Pre-designed siRNA Set A

HY-RS14766

TMPRSS11E Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMPRSS11E Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS11E gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMPRSS11E Human Pre-designed siRNA Set A TMPRSS11E Human Pre-designed siRNA Set A

HY-RS14764

TMPRSS11B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMPRSS11B Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS11B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMPRSS11B Human Pre-designed siRNA Set A TMPRSS11B Human Pre-designed siRNA Set A

HY-B1624C

Debrisoquin hydrobromide Debrisoquine hydrobromide; Isocaramidine hydrobromide; Ro 5-3307/1 hydrobromide	SARS-CoV Ser/Thr Protease	Infection
Debrisoquine (Ro 5-3307/1) hydrobromide is a *TMPRSS2* inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC₅₀ of 22μM. Debrisoquine hydrobromide can be used for antiviral research .

HY-157021

SARS-CoV-2-IN-66	SARS-CoV	Infection Inflammation/Immunology
SARS-CoV-2-IN-66 (1), a vitaminK derivative, is a SARS-CoV-2 inhibitor, with an EC₅₀ of 70.8 μM in VeroE6/TMPRSS2 cells .

Cat. No.	Product Name	Type

HY-134432B

Boc-Gln-Ala-Arg-AMC acetate 1 Publications Verification	Fluorescent Dyes
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .

Cat. No.	Product Name	Target	Research Area

HY-134432B

Boc-Gln-Ala-Arg-AMC acetate 1 Publications Verification	Ser/Thr Protease	Others
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .

HY-P11260

MD5	Ser/Thr Protease Thrombin	Metabolic Disease
MD5 is a selective *TMPRSS6* mimetic peptide inhibitor with an IC₅₀ for recombinant human TMPRSS6 protein of 22 nM and a K_i of 3.4 nM. MD5 exhibits the significantly reduced inhibitory effect on Matriptase, with an IC₅₀ of 352 nM and a K_i of 99.2 nM. MD5 exhibits good target specificity and only has a weak inhibitory effect on thrombin (Thrombin), with K_i of 120 nM. MD5 demonstrates good initial drugability and can be used for the study of iron overload diseases (such as hereditary hemochromatosis, β-thalassemia) .

HY-173459

N-0920	SARS-CoV	Infection
N-0920 is a potent *TMPRSS2* inhibitor with an IC₅₀ of 0.35 nM. N-0920 effectively inhibits SARS-CoV-2 variants EG.5.1 and JN.1 entry in Calu-3 cells, with picomolar EC₅₀s values of 300 pM and 90 pM, respectively .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990524

*Anti-TMPRSS2 Antibody*	Ser/Thr Protease	Inflammation/Immunology
The Anti-TMPRSS2 Antibody is a CHO-expressed humanized antibody that targets *TMPRSS2. The Anti-TMPRSS2 Antibody features a huIgG1 heavy chain and a huκ light chain, with an expected molecular weight (MW) of 150 kDa. For the isotype control of the Anti-TMPRSS*2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991637

REGN7999	Ser/Thr Protease	Metabolic Disease
REGN7999 is a monoclonal antibody that inhibits *TMPRSS6. REGN7999 inhibits TMPRSS6 activity, preventing Hemojuvelin (HJV) lysis, thereby enhancing BMP6-HJV signaling and increasing serum hepcidin. REGN7999 ameliorates iron overload and impaired erythropoiesis in a β-thalassemia mouse model by inhibiting TMPRSS*6 activity. REGN7999 is indicated for research in β-thalassemia .

HY-P991137

Exerenibart	Ser/Thr Protease	Metabolic Disease
Exerenibart is an immunoglobulin G4-κ monoclonal antibody targeting human transmembrane serine protease 6 (TMPRSS6). Exerenibart is promising for research of diseases associated with iron metabolism disorders, such as iron overload or iron deficiency .

HY-P992451

RLYB331 KY1066	Ser/Thr Protease Hepcidin Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease
RLYB331 (KY1066) is a is a monoclonal antibody targeting Matriptase-2 (TMPRSS6) . RLYB331 binds to the serine protease active site of matriptase-2, blocking protease activity to increase hepcidin expression. RLYB331 reduces iron overload, inhibits α-aggregates, reduces ROS, inhibits apoptosis, and enhances erythroid differentiation. RLYB331 ameliorates ineffective erythropoiesis in β-thalassemic mouse models. RLYB331 can be used for the research of β-thalassemia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13512

Camostat mesylate 40+ Cited Publications Camostat mesilate; FOY305; FOY-S980	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Ser/Thr Protease SARS-CoV
Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of *TMPRSS2, shows antiviral activity against SARS-CoV-2*. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

HY-B1624A

Debrisoquin hemisulfate Debrisoquine hemisulfate; Isocaramidine hemisulfate; Ro 5-3307/1 hemisulfate	Infection Alkaloids Classification of Application Fields Endogenous metabolite Isoquinoline Alkaloids Disease Research Fields Source Classification	Endogenous Metabolite
Debrisoquin (Isocaramidine) hemisulfate is a *TMPRSS2* inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC₅₀ of 22μM. Debrisoquin hemisulfate can be used for antiviral research .

HY-W749874

Qingdainone 1 Publications Verification	Structural Classification Flavonoids Acanthaceae Plants Other Flavonoids Jacobaea cannabifolia (Less.) E. Wiebe Source Classification	Ser/Thr Protease
Qingdainone is a quinazoline alkaloid and also a *TMPRSS2* inhibitor. Qingdainone can be isolated from Strobilanthes cusia. Qingdainone exhibits anti-tumor and anti-inflammatory activities. Qingdainone can be used in studies related to chronic myeloid leukemia .

HY-13512R

Camostat mesylate (Standard) Camostat mesilate (Standard); FOY305 (Standard); FOY-S980 (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Ser/Thr Protease SARS-CoV
Camostat (mesylate) (Standard) is the analytical standard of Camostat (mesylate). This product is intended for research and analytical applications. Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of *TMPRSS2, shows antiviral activity against SARS-CoV-2*. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

Species:	Human (10) Mouse (3)
Tag:	SUMO (1) His (12) Tag Free (1)
Source:	HEK293 (7) P. pastoris (2) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77693

	TMPRSS1/HPN Protein, Human (HEK293, His) Hpxn; FLJ56652; Hemopexin; HPX; HX; Hepsin; HPN; TMPRSS1	Human	HEK293
	TMPRSS1/HPN is a serine protease that cleaves extracellular substrates and is involved in the proteolytic processing of growth factors such as HGF and MST1/HGFL. In addition to growth factor regulation, TMPRSS1/HPN is also critical for cell growth and morphology maintenance. TMPRSS1/HPN Protein, Human (HEK293, His) is the recombinant human-derived TMPRSS1/HPN protein, expressed by HEK293 , with C-His labeled tag.

HY-P77693Y

	TMPRSS1/HPN Protein, Human (HEK293, His, solution) Hpxn; FLJ56652; Hemopexin; HPX; HX; Hepsin; HPN; TMPRSS1	Human	HEK293

HY-P70869

	TMPRSS11B Protein, Human (HEK293, His) Transmembrane Protease Serine 11B; Airway Trypsin-Like Protease 5; TMPRSS11B; HATL5	Human	HEK293
	TMPRSS11B, a serine protease, is susceptible to inhibition by aprotinin, leupeptin, benzamidine, SERPINA1, SPINT1, and SPINT2, highlighting its susceptibility to various regulatory mechanisms. TMPRSS11B Protein, Human (HEK293, His) is the recombinant human-derived TMPRSS11B protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72043

	TMPRSS2 Protein, Human (P.pastoris, His) 1 Publications Verification Serine protease 10; PRSS10;	Human	P. pastoris
	The TMPRSS2 protein is a plasma membrane-anchored serine protease that plays critical roles in prostate physiology, cancer metastasis, pain modulation, and viral infection. Its lytic activity affects proteolytic cascades involved in prostate function, and androgen-induced activation contributes to cancer progression. TMPRSS2 Protein, Human (P.pastoris, His) is the recombinant human-derived TMPRSS2 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P72044

	TMPRSS2 Protein, Human (R255Q, HEK293, His) Serine protease 10	Human	HEK293
	The TMPRSS2 protein is a plasma membrane-anchored serine protease that plays critical roles in prostate physiology, cancer metastasis, pain modulation, and viral infection. Its lytic activity affects proteolytic cascades involved in prostate function, and androgen-induced activation contributes to cancer progression. TMPRSS2 Protein, Human (R255Q, HEK293, His) is the recombinant human-derived TMPRSS2 protein, expressed by HEK293 , with N-10*His labeled tag and R255Q mutation.

HY-P77961

	Hepsin/HPN Protein, Mouse (HEK293, His) Hpxn; FLJ56652; Hemopexin; HPX; HX; Hepsin; HPN; TMPRSS1	Mouse	HEK293
	Hepsin/HPN is a serine protease that cleaves extracellular substrates and contributes significantly to the processing of growth factors such as HGF and MST1/HGFL. It plays a vital role in cell growth and morphology maintenance. Hepsin/HPN Protein, Mouse (HEK293, His) is the recombinant mouse-derived Hepsin/HPN protein, expressed by HEK293 , with C-His labeled tag.

HY-P76680

	TMPRSS11D Protein, Human (HEK293, His) Transmembrane protease serine 11D; Airway trypsin-like protease; HAT	Human	HEK293
	The TMPRSS11D protein is associated with host mucosal defense and acts synergistically with substances in the airway mucosa. It critically processes ACE2, activating the human coronavirus 229E spike glycoprotein to achieve virus-cell membrane fusion. TMPRSS11D Protein, Human (HEK293, His) is the recombinant human-derived TMPRSS11D protein, expressed by HEK293 , with N-His labeled tag.

HY-P71733

	ERG Protein, Human (P.pastoris, His) ERG3; included; ets related; ETS-related gene; KCNH2; Oncogene TMPRSS2/ERG fusion	Human	P. pastoris
	ERG Protein, a transcriptional regulator, recruits SETDB1 histone methyltransferase to modify local chromatin. It interacts with SETDB1 and is identified in an IGF2BP1-dependent mRNP granule complex with untranslated mRNAs. ERG Protein, Human (P.pastoris, His) is the recombinant human-derived ERG protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P71604

	Transmembrane protease serine 4 Protein, Mouse (His-SUMO) TMPRSS4; Cap2; Transmembrane protease serine 4; EC 3.4.21.-; Channel-activating protease 2; mCAP2	Mouse	E. coli
	The transmembrane protease serine 4 (TMPRSS4) protein is a plasma membrane-anchored serine protease that is critical for activating molecular pathways. Its proteolytic activity directly processes pro-uPA/PLAU into its active form. Transmembrane protease serine 4 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Transmembrane protease serine 4 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P702508

	Enterokinase Protein, Human (HEK293, His) EC 3.4.21; EC 3.4.21.9; Enterokinase; Enteropeptidase; ENTK; ENTKenterokinase; MGC133046; protease, serine, 7 (enterokinase); PRSS7; PRSS7enteropeptidase; Serine protease 7; TMPRSS15; Transmembrane protease serine 15; transmembrane protease, serine 15	Human	HEK293
	Enterokinase Protein initiates the activation of pancreatic proteolytic proenzymes, including trypsin, chymotrypsin, and carboxypeptidase A. It catalyzes the conversion of trypsinogen to trypsin, triggering the activation of other proenzymes like chymotrypsinogen, procarboxypeptidases, and proelastases. Enterokinase Protein, Human (HEK293, His) is the recombinant human-derived Enterokinase protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P702524

	Matriptase/ST14 Catalytic Domain Protein, Mouse (His) EC 3.4.21; Epithin; HAI; Matriptase; Membrane-type serine protease 1; MTSP1; MT-SP1EC 3.4.21.109; prostamin; PRSS14; Serine protease 14; Serine protease TADG-15; SNC19; SNC19MTSP1; ST14; suppressor of tumorigenicity 14 protein; TADG15; TADG-15; TMPRSS14; tumor associated differentially expressed gene 15 protein; Tumor-associated differentially-expressed gene 15 protein	Mouse	E. coli
	The Matriptase/ST14 catalytic domain protein exhibits serine-type endopeptidase activity and is critical in processes as diverse as placental branching and neural tube closure. It is an extrinsic component of the plasma membrane and is expressed in structures such as the digestive system, early concepts, genitourinary system, pituitary gland, and sense organs. Matriptase/ST14 Catalytic Domain Protein, Mouse (His) is the recombinant mouse-derived Matriptase/ST14 Catalytic Domain protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702523

	Matriptase/ST14 Catalytic Domain Protein, Human (His) EC 3.4.21; Epithin; HAI; Matriptase; Membrane-type serine protease 1; MTSP1; MT-SP1EC 3.4.21.109; prostamin; PRSS14; Serine protease 14; Serine protease TADG-15; SNC19; SNC19MTSP1; ST14; suppressor of tumorigenicity 14 protein; TADG15; TADG-15; TMPRSS14; tumor associated differentially expressed gene 15 protein; Tumor-associated differentially-expressed gene 15 protein	Human	E. coli
	The Matriptase/ST14 catalytic domain protein originates from epithelial cells, forms a complex with HAI-1, and is activated by sphingosine-1-phosphate. It cleaves and activates hepatocyte growth factor/scatter factor and urokinase plasminogen activator, suggesting its role as an activator of other proteases and potential growth factors. Matriptase/ST14 Catalytic Domain Protein, Human (His) is the recombinant human-derived Matriptase/ST14 Catalytic Domain protein, expressed by E. coli , with N-6*His labeled tag.

HY-P704778

	Matriptase/ST14 Catalytic Domain Protein, Human EC 3.4.21; Epithin; HAI; Matriptase; Membrane-type serine protease 1; MTSP1; MT-SP1EC 3.4.21.109; prostamin; PRSS14; Serine protease 14; Serine protease TADG-15; SNC19; SNC19MTSP1; ST14; suppressor of tumorigenicity 14 protein; TADG15; TADG-15; TMPRSS14; tumor associated differentially expressed gene 15 protein; Tumor-associated differentially-expressed gene 15 protein	Human	E. coli
	The Matriptase/ST14 catalytic domain protein originates from epithelial cells, forms a complex with HAI-1, and is activated by sphingosine-1-phosphate. It cleaves and activates hepatocyte growth factor/scatter factor and urokinase plasminogen activator, suggesting its role as an activator of other proteases and potential growth factors. Matriptase/ST14 Catalytic Domain Protein, Human is the recombinant human-derived Matriptase/ST14 Catalytic Domain protein, expressed by E. coli, with tag free.

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HY-B0372AS

Bromhexine-d3 hydrochloride

Bromhexine-d₃ (hydrochloride) is deuterium labeled Bromhexine (hydrochloride). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC₅₀ of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions .

Host:	Mouse (4) Rabbit (1)
Reactivity:	Human (3) Rat (1) Mouse (1) human (2)
Application:	IHC-P (1) ICC/IF (5) IF-Tissue (2) IP (2) WB (3) FC (3) ELISA (2)
Isotype:	IgG (1) IgG1 (3) IgG2b (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88660

	TMPRSS5 Antibody (YA8344) SPINESIN	ICC/IF, FC	Human
	TMPRSS5 Antibody (YA8344) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TMPRSS5.

HY-P89692

	TMPRSS4 Antibody (YA9036) TMPRSS3, UNQ776/PRO1570, TMPRSS4, Transmembrane protease serine 4, Channel-activating protease 2, Membrane-type serine protease 2, CAPH2, MT-SP2	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	TMPRSS4 Antibody (YA9036) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TMPRSS4.

HY-P88660A

	TMPRSS5 Antibody (YA8344)(PBS only) SPINESIN	ICC/IF, FC	Human
	TMPRSS5 Antibody (YA8344) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TMPRSS5.

HY-P82611

	Transmembrane Protease Serine 2 Antibody (YA2356) Epitheliasin; PRSS10; TMPRSS2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Transmembrane Protease Serine 2 Antibody (YA2356) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protease Serine 2.

HY-P89613

	Matriptase-2 Antibody (YA8957) UNQ354/PRO618, TMPRSS6, Transmembrane protease serine 6, Matriptase-2	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	Matriptase-2 Antibody (YA8957) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Matriptase-2.

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Cat. No.	Product Name		Classification

HY-114402

ARD-69		PROTAC Synthesis
ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor, which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells. ARD-69 inhibits AR-regulated gene expression, binds to the AR ligand binding domain at one end and binds to VHL at the other end, prompting AR to be recruited to the E3 ubiquitin ligase complex, triggering proteasome degradation, thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA, TMPRSS2). ARD-69 can be used to study of castration-resistant prostate cancer (mCRPC) . ARD-69 is composed of a target protein ligand (pink part) AR antagonist 14 (HY-172624), a PROTAC linker (black part) tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and a VHL-type E3 ubiquitinase ligand (blue part) VH 101, acid (HY-47070); among them, the VHL ligand and the linker can form a conjugate VH 101-amide-piperidine-Pip-alkyne (HY-172625).

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