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Cat. No.: HY-163067

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SARS-CoV-2-IN-71

SARS-CoV-2-IN-71 (compound 8h) is a potent inhibitor of SARS-CoV-2. SARS-CoV-2-IN-71 inhibits coronavirus replication at multiple stages. SARS-CoV-2-IN-71 displays anti-coronaviral effect by simultaneously acting on 3CL^pro and TMPRSS2.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₄F₆N₄O₄
Molecular Weight:534.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

SARS-CoV-2-IN-71 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>100 μM Compound: 8h	Cytotoxicity against human A549 cells incubated for 72 hrs by CCK-8 assay Cytotoxicity against human A549 cells incubated for 72 hrs by CCK-8 assay	[PMID: 38061229]
Huh-7	CC₅₀	>50 μM Compound: 8h	Cytotoxicity against human Huh-7 cells incubated for 72 hrs by CCK-8 assay Cytotoxicity against human Huh-7 cells incubated for 72 hrs by CCK-8 assay	[PMID: 38061229]
Huh-7.5	CC₅₀	>50 μM Compound: 8h	Cytotoxicity against human Huh7.5 cells incubated for 72 hrs by CCK-8 assay Cytotoxicity against human Huh7.5 cells incubated for 72 hrs by CCK-8 assay	[PMID: 38061229]
NCI-H460	CC₅₀	67.03 μM Compound: 8h	Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by CCK-8 assay Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by CCK-8 assay	[PMID: 38061229]

Chemical Information

Molecular Weight 534.45
Formula C₂₃H₂₄F₆N₄O₄
SMILES

O=C(NC1=CC=C(C(C(F)(F)F)=C1)CN2CC(C2)N(C)C)C(C=C3[N+]([O-])=O)=CC=C3OCCC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li J, et al. Design, synthesis and biological evaluation of biaryl amide derivatives against SARS-CoV-2 with dual-target mechanism. Eur J Med Chem. 2023 Nov 25;264:115978. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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