BC-11 hydrobromide

Cat. No.: HY-108447 Purity: 98.50%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC₅₀=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer.

For research use only. We do not sell to patients.

BC-11 hydrobromide Chemical Structure

CAS No. : 443776-49-6

Size	Price	Stock	Quantity
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 8.2 μM (uPA)^[3].

Molecular Weight

290.97

Formula

C₈H₁₂BBrN₂O₂S

CAS No.

443776-49-6

Appearance

Solid

Color

White to off-white

SMILES

NC(SCC1=CC=C(B(O)O)C=C1)=N.[H]Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (429.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4368 mL	17.1839 mL	34.3678 mL
5 mM	0.6874 mL	3.4368 mL	6.8736 mL
10 mM	0.3437 mL	1.7184 mL	3.4368 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.50%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (246 KB) HNMR (268 KB) RP-HPLC (202 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Moumbock AFA, et al. BC-11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS-CoV-2 host cell entry. Arch Pharm (Weinheim). 2023 Jan;356(1):e2200371. [Content Brief]

[2]. Semina E, et al. Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching. Eur J Cell Biol. 2016 Sep;95(9):295-310. [Content Brief]

[3]. Longo A, et al. Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells. Molecules. 2015 May 28;20(6):9879-89. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4368 mL	17.1839 mL	34.3678 mL	85.9195 mL
	5 mM	0.6874 mL	3.4368 mL	6.8736 mL	17.1839 mL
	10 mM	0.3437 mL	1.7184 mL	3.4368 mL	8.5920 mL
	15 mM	0.2291 mL	1.1456 mL	2.2912 mL	5.7280 mL
	20 mM	0.1718 mL	0.8592 mL	1.7184 mL	4.2960 mL
	25 mM	0.1375 mL	0.6874 mL	1.3747 mL	3.4368 mL
	30 mM	0.1146 mL	0.5728 mL	1.1456 mL	2.8640 mL
	40 mM	0.0859 mL	0.4296 mL	0.8592 mL	2.1480 mL
	50 mM	0.0687 mL	0.3437 mL	0.6874 mL	1.7184 mL
	60 mM	0.0573 mL	0.2864 mL	0.5728 mL	1.4320 mL
	80 mM	0.0430 mL	0.2148 mL	0.4296 mL	1.0740 mL
	100 mM	0.0344 mL	0.1718 mL	0.3437 mL	0.8592 mL