Cbz-QFR-kbt
Cbz-QFR-kbt is a ketone-based benzothiazole ketone inhibitor of TMPRSS2, with an IC50 value of 0.42 nM. Cbz-QFR-kbt also has inhibitory activity against Matriptase, Hepsin, HGFA, and Factor Xa, with IC50 values of 1, 1.3, 85, and 85 nM respectively. Cbz-QFR-kbt shows significant inhibitory effects against SARS-CoV-2 and H1N1 (IC50 = 60 nM). Cbz-QFR-kbt can be used in antiviral research.
For research use only. We do not sell to patients.
- CAS No.: 3086979-57-6
- Formula: C35H40N8O6S
- Molecular Weight:700.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
| Species | Dose | Route | Tmax | Cmax | AUClast | T1/2 |
|---|---|---|---|---|---|---|
| Mice[1] | 2 mg/kg | i.v. | 0.08 h | 3983 ng/mL | 791 ng·h/mL | 0.5 h |
Chemical Information
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CAS No. 3086979-57-6
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Molecular Weight 700.81
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Formula C35H40N8O6S
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SMILES
NC(NCCC[C@@H](C(C1=NC(C=CC=C2)=C2S1)=O)NC([C@H](CC3=CC=CC=C3)NC([C@H](CCC(N)=O)NC(OCC4=CC=CC=C4)=O)=O)=O)=N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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