2. Metabolic Enzyme/Protease Anti-infection
  3. Ser/Thr Protease Factor Xa SARS-CoV Influenza Virus
  4. Cbz-QFR-kbt

Cbz-QFR-kbt is a ketone-based benzothiazole ketone inhibitor of TMPRSS2, with an IC50 value of 0.42 nM. Cbz-QFR-kbt also has inhibitory activity against Matriptase, Hepsin, HGFA, and Factor Xa, with IC50 values of 1, 1.3, 85, and 85 nM respectively. Cbz-QFR-kbt shows significant inhibitory effects against SARS-CoV-2 and H1N1 (IC50 = 60 nM). Cbz-QFR-kbt can be used in antiviral research.

For research use only. We do not sell to patients.

Cbz-QFR-kbt

Cbz-QFR-kbt Chemical Structure

CAS No. : 3086979-57-6

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Cbz-QFR-kbt Related Antibodies

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Description

Cbz-QFR-kbt is a ketone-based benzothiazole ketone inhibitor of TMPRSS2, with an IC50 value of 0.42 nM. Cbz-QFR-kbt also has inhibitory activity against Matriptase, Hepsin, HGFA, and Factor Xa, with IC50 values of 1, 1.3, 85, and 85 nM respectively. Cbz-QFR-kbt shows significant inhibitory effects against SARS-CoV-2 and H1N1 (IC50 = 60 nM). Cbz-QFR-kbt can be used in antiviral research[1].

Parmacokinetics
Species Dose Route Tmax Cmax AUClast T1/2
Mice[1] 2 mg/kg i.v. 0.08 h 3983 ng/mL 791 ng·h/mL 0.5 h
Molecular Weight

700.81

Formula

C35H40N8O6S
CAS No.
SMILES

NC(NCCC[C@@H](C(C1=NC(C=CC=C2)=C2S1)=O)NC([C@H](CC3=CC=CC=C3)NC([C@H](CCC(N)=O)NC(OCC4=CC=CC=C4)=O)=O)=O)=N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cbz-QFR-kbt Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cbz-QFR-kbt3086979-57-6Ser/Thr ProteaseFactor XaSARS-CoVInfluenza VirusSerine proteasesSerine endopeptidasesThreonine proteasesFxaSARS coronavirusketobenzothiazole derivativesSARS-CoV-2H1N1 influenzahost-directed antiviralsserine protease inhibitorsviral entry inhibitionbroad-spectrum antiviralsstructure-activity relationshippharmacokineticsInhibitorinhibitorinhibit

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