2. Vitamin D Related/Nuclear Receptor
    PROTAC
  3. Androgen Receptor
    PROTACs
  4. ARD-69

ARD-69 

Cat. No.: HY-114402 Purity: 99.75%
COA Handling Instructions

ARD-69 (compound 34) is a potent PROTAC androgen receptor degrader. ARD-69 induces degradation of androgen receptor (AR) protein in AR-positive prostate cancer cell lines. ARD-69 suppresses AR-regulated gene expression.

For research use only. We do not sell to patients.

ARD-69 Chemical Structure

ARD-69 Chemical Structure

CAS No. : 2316837-10-0

Size Price Stock Quantity
1 mg USD 750 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 5200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 8350 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

ARD-69 (compound 34) is a potent PROTAC androgen receptor degrader. ARD-69 induces degradation of androgen receptor (AR) protein in AR-positive prostate cancer cell lines. ARD-69 suppresses AR-regulated gene expression[1].

IC50 & Target

Androgen receptor (AR)[1]
PROTAC[1]
Molecular Weight

1129.82

Appearance

Solid

Formula

C62H74ClFN8O7S
CAS No.
SMILES

ClC1=CC(O[[email protected]]2C(C)(C)[[email protected]](NC(C3=CC=C(C#CC4CCN(C5CCN(C(C[[email protected]](NC([[email protected]]6N(C([[email protected]@H](NC(C7(CC7)F)=O)C(C)(C)C)=O)C[[email protected]](O)C6)=O)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)CC5)CC4)C=C3)=O)C2(C)C)=CC=C1C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : ≥ 200 mg/mL (177.02 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8851 mL 4.4255 mL 8.8510 mL
5 mM 0.1770 mL 0.8851 mL 1.7702 mL
10 mM 0.0885 mL 0.4425 mL 0.8851 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

ARD-692316837-10-0ARD69ARD 69Androgen ReceptorPROTACsAR-positive prostate cancer cell linesgene expressionInhibitorinhibitorinhibit

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