ARD-1676
Based on 1 publication(s) in Google Scholar
ARD-1676 is an orally available androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. ARD-1676 has AR-degrading activity in vitro and in vivo and inhibits VCaP tumor growth in mouse xenograft tumor models.
(Pink: Androgen Receptor ligand (HY-150878); Blue: Cereblon ligand (HY-W248665); Black: linker).
For research use only. We do not sell to patients.
- Purity: 99.36%
- CAS No.: 2632305-36-1
- Formula: C44H46ClN7O5
- Molecular Weight:788.33
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) ARD-1676
MoreAll PROTACs Isoforms
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
2.8 nM
Compound: 39; ARD-1676
|
Growth inhibition in human LNCaP cells assessed as reduction in cell viability
Growth inhibition in human LNCaP cells assessed as reduction in cell viability
|
[PMID: 37683104] |
| VCaP | IC50 |
11.5 nM
Compound: 39; ARD-1676
|
Growth inhibition in human VCaP cells
Growth inhibition in human VCaP cells
|
[PMID: 37683104] |
The DC50 values of ARD-1676 for AR degradation in AR+ VCaP and LNCaP cell lines are 0.1 and 1.1 nM, respectively, and the IC50 values in VCaP and LNCaP cell lines are 11.5 and 2.8 nM respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2632305-36-1
-
Appearance Solid
-
Molecular Weight 788.33
-
Formula C44H46ClN7O5
-
Color White to light yellow
-
SMILES
C[C@H]1CC2(CN1C3=CC=C(C(Cl)=C3)C#N)CCN(CC2)C4=CC=C(C=C4)C(N5CCC(CC5)CN6CC7=C(C6)C=C8C(N(C(C8=C7)=O)C9CCC(NC9=O)=O)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Anal Chem
Hydrogen/Deuterium Exchange for Chiral Stability Assessment in Acidic Methine-Containing Compounds. [Abstract]2025 Dec 2;97(47):26097-26107. PMID: 41243541
Solvent & Solubility
DMSO : 100 mg/mL (126.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (269 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2685 mL | 6.3425 mL | 12.6850 mL | 31.7126 mL |
| 5 mM | 0.2537 mL | 1.2685 mL | 2.5370 mL | 6.3425 mL | |
| 10 mM | 0.1269 mL | 0.6343 mL | 1.2685 mL | 3.1713 mL | |
| 15 mM | 0.0846 mL | 0.4228 mL | 0.8457 mL | 2.1142 mL | |
| 20 mM | 0.0634 mL | 0.3171 mL | 0.6343 mL | 1.5856 mL | |
| 25 mM | 0.0507 mL | 0.2537 mL | 0.5074 mL | 1.2685 mL | |
| 30 mM | 0.0423 mL | 0.2114 mL | 0.4228 mL | 1.0571 mL | |
| 40 mM | 0.0317 mL | 0.1586 mL | 0.3171 mL | 0.7928 mL | |
| 50 mM | 0.0254 mL | 0.1269 mL | 0.2537 mL | 0.6343 mL | |
| 60 mM | 0.0211 mL | 0.1057 mL | 0.2114 mL | 0.5285 mL | |
| 80 mM | 0.0159 mL | 0.0793 mL | 0.1586 mL | 0.3964 mL | |
| 100 mM | 0.0127 mL | 0.0634 mL | 0.1269 mL | 0.3171 mL |
Powered by Bioz