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Cat. No.: HY-W248665

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Thalidomide-pyrrolidine

Thalidomide-pyrrolidine is an E3 ligase ligand. Thalidomide-pyrrolidine can be used for synthesis of PROTAC ARD-1676 (HY-156111).

For research use only. We do not sell to patients.

CAS No.: 2616540-83-9
Formula: C₁₅H₁₃N₃O₄
Molecular Weight:299.28

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (268 KB)

Thalidomide-pyrrolidine Chemical Structure

CAS No.: 2616540-83-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Thalidomide-pyrrolidine is an E3 ligase ligand. Thalidomide-pyrrolidine can be used for synthesis of PROTAC ARD-1676 (HY-156111)^[1].

IC₅₀ & Target^[1]

Cereblon

All Ligands for E3 Ligase Isoforms :

Chemical Information

CAS No. 2616540-83-9
Appearance Solid
Molecular Weight 299.28
Formula C₁₅H₁₃N₃O₄
Color off-white
SMILES

O=C1NC(C(CC1)N2C(C3=C(C2=O)C=C(CNC4)C4=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiang W, et al. Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer. J Med Chem. 2023 Sep 28;66(18):13280-13303. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Thalidomide-pyrrolidine

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Thalidomide-pyrrolidine Related Classifications

HY-W248665 Related Classifications