Thalidomide-pyrrolidine hydrochloride

Name: Thalidomide-pyrrolidine hydrochloride
Brand: MedChemExpress
SKU: HY-W248665A
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製品番号: HY-W248665A 純度: 98.0%: Data Sheet SDS COA 取扱説明書
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Technical Support

Thalidomide-pyrrolidine hydrochloride (Compound 18) is an E3 ligase ligand. Thalidomide-pyrrolidine serves as a building block for the synthesis of PROTAC ARD-1676 (HY-156111).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Thalidomide-pyrrolidine hydrochloride 構造式

CAS 番号 : 2616553-35-4

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 27	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 27	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$25	在庫あり	Estimated Time of Arrival: December 31
10 mg	$38	在庫あり	Estimated Time of Arrival: December 31
25 mg	$66	在庫あり	Estimated Time of Arrival: December 31
50 mg	$106	在庫あり	Estimated Time of Arrival: December 31
100 mg	$170	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Thalidomide-pyrrolidine hydrochloride:

Thalidomide-pyrrolidine お問い合わせ

Ligands for E3 Ligase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41 RNF114 DDB1 FEM1B

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Thalidomide-pyrrolidine hydrochloride (Compound 18) is an E3 ligase ligand. Thalidomide-pyrrolidine serves as a building block for the synthesis of PROTAC ARD-1676 (HY-156111)^[1].

IC₅₀ & Target

Cereblon

体外実験

Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

335.74

分子式

C₁₅H₁₄ClN₃O₄

CAS 番号

2616553-35-4

Appearance

Solid

Color

Off-white to gray

SMILES

O=C1NC(C(CC1)N2C(C3=C(C2=O)C=C(CNC4)C4=C3)=O)=O.[H]Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Store at room temperature, keep dry and cool

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature, keep dry and cool)

溶剤 & 溶解度

体外:

H₂O : 25 mg/mL (74.46 mM; ultrasonic and warming and heat to 60°C)

DMSO : 2 mg/mL (5.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9785 mL	14.8925 mL	29.7850 mL
5 mM	0.5957 mL	2.9785 mL	5.9570 mL
10 mM	0.2978 mL	1.4892 mL	2.9785 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: ≥98.0%

Select Batch:

データシート (271 KB) SDS (251 KB)

COA (250 KB) HNMR (131 KB) MS (304 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Shao MW, et, al. Androgen receptor protein degraders with a tricyclic cereblon ligand. WO2021231927A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.9785 mL	14.8925 mL	29.7850 mL	74.4624 mL
DMSO / H₂O	5 mM	0.5957 mL	2.9785 mL	5.9570 mL	14.8925 mL
H₂O	10 mM	0.2978 mL	1.4892 mL	2.9785 mL	7.4462 mL
	15 mM	0.1986 mL	0.9928 mL	1.9857 mL	4.9642 mL
	20 mM	0.1489 mL	0.7446 mL	1.4892 mL	3.7231 mL
	25 mM	0.1191 mL	0.5957 mL	1.1914 mL	2.9785 mL
	30 mM	0.0993 mL	0.4964 mL	0.9928 mL	2.4821 mL
	40 mM	0.0745 mL	0.3723 mL	0.7446 mL	1.8616 mL
	50 mM	0.0596 mL	0.2978 mL	0.5957 mL	1.4892 mL
	60 mM	0.0496 mL	0.2482 mL	0.4964 mL	1.2410 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.