Thalidomide-pyrrolidine hydrochloride

Name: Thalidomide-pyrrolidine hydrochloride
Brand: MedChemExpress
SKU: HY-W248665A
Rating: 4.5 (1 reviews)

Cat. No.: HY-W248665A Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Thalidomide-pyrrolidine hydrochloride (Compound 18) is an E3 ligase ligand. Thalidomide-pyrrolidine serves as a building block for the synthesis of PROTAC ARD-1676 (HY-156111).

For research use only. We do not sell to patients.

Thalidomide-pyrrolidine hydrochloride Chemical Structure

CAS No. : 2616553-35-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-pyrrolidine hydrochloride:

Thalidomide-pyrrolidine Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Biological Activity
Purity & Documentation
References
Customer Review

Description

Thalidomide-pyrrolidine hydrochloride (Compound 18) is an E3 ligase ligand. Thalidomide-pyrrolidine serves as a building block for the synthesis of PROTAC ARD-1676 (HY-156111)^[1].

IC₅₀ & Target

Cereblon

In Vitro

Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

335.74

Formula

C₁₅H₁₄ClN₃O₄

CAS No.

2616553-35-4

Appearance

Solid

Color

Off-white to gray

SMILES

O=C1NC(C(CC1)N2C(C3=C(C2=O)C=C(CNC4)C4=C3)=O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (74.46 mM; ultrasonic and warming and heat to 60°C)

DMSO : 2 mg/mL (5.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9785 mL	14.8925 mL	29.7850 mL
5 mM	0.5957 mL	2.9785 mL	5.9570 mL
10 mM	0.2978 mL	1.4892 mL	2.9785 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (250 KB) HNMR (131 KB) MS (304 KB)

Handling Instructions (2659 KB)

References

[1]. Shao MW, et, al. Androgen receptor protein degraders with a tricyclic cereblon ligand. WO2021231927A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.9785 mL	14.8925 mL	29.7850 mL	74.4624 mL
DMSO / H₂O	5 mM	0.5957 mL	2.9785 mL	5.9570 mL	14.8925 mL
H₂O	10 mM	0.2978 mL	1.4892 mL	2.9785 mL	7.4462 mL
	15 mM	0.1986 mL	0.9928 mL	1.9857 mL	4.9642 mL
	20 mM	0.1489 mL	0.7446 mL	1.4892 mL	3.7231 mL
	25 mM	0.1191 mL	0.5957 mL	1.1914 mL	2.9785 mL
	30 mM	0.0993 mL	0.4964 mL	0.9928 mL	2.4821 mL
	40 mM	0.0745 mL	0.3723 mL	0.7446 mL	1.8616 mL
	50 mM	0.0596 mL	0.2978 mL	0.5957 mL	1.4892 mL
	60 mM	0.0496 mL	0.2482 mL	0.4964 mL	1.2410 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.