Thalidomide-pyrrolidine hydrochloride
Based on 1 Customer Validation
Thalidomide-pyrrolidine hydrochloride (Compound 18) is an E3 ligase ligand. Thalidomide-pyrrolidine serves as a building block for the synthesis of PROTAC ARD-1676 (HY-156111).
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 2616553-35-4
- Formula: C15H14ClN3O4
- Molecular Weight:335.74
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cereblon |
Chemical Information
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CAS No. 2616553-35-4
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Appearance Solid
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Molecular Weight 335.74
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Formula C15H14ClN3O4
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Color Off-white to gray
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SMILES
O=C1NC(C(CC1)N2C(C3=C(C2=O)C=C(CNC4)C4=C3)=O)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
H2O : 25 mg/mL (74.46 mM; ultrasonic and warming and heat to 60°C)
DMSO : 2 mg/mL (5.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.9785 mL | 14.8925 mL | 29.7850 mL | 74.4624 mL |
| 5 mM | 0.5957 mL | 2.9785 mL | 5.9570 mL | 14.8925 mL | |
| H2O | 10 mM | 0.2978 mL | 1.4892 mL | 2.9785 mL | 7.4462 mL |
| 15 mM | 0.1986 mL | 0.9928 mL | 1.9857 mL | 4.9642 mL | |
| 20 mM | 0.1489 mL | 0.7446 mL | 1.4892 mL | 3.7231 mL | |
| 25 mM | 0.1191 mL | 0.5957 mL | 1.1914 mL | 2.9785 mL | |
| 30 mM | 0.0993 mL | 0.4964 mL | 0.9928 mL | 2.4821 mL | |
| 40 mM | 0.0745 mL | 0.3723 mL | 0.7446 mL | 1.8616 mL | |
| 50 mM | 0.0596 mL | 0.2978 mL | 0.5957 mL | 1.4892 mL | |
| 60 mM | 0.0496 mL | 0.2482 mL | 0.4964 mL | 1.2410 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thalidomide-pyrrolidine hydrochloride Related Classifications
HY-W248665A Related Classifications
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