BMS-986365

Cat. No.: HY-158101: FAQs
Data Sheet Handling Instructions

Molarity Calculator

BMS-986365 is a selective heterobifunctional ligand-directed degrader (LDD) targeting the androgen receptor (AR). BMS-986365 demonstrated significant in vivo potency, degrading AR, inhibiting AR signaling, and inhibiting tumor growth in animal models of advanced prostate cancer.

For research use only. We do not sell to patients.

BMS-986365 Chemical Structure

CAS No. : 2446928-30-7

Size	Price	Stock
5 mg	USD 588	Ask For Quote & Lead Time
10 mg	USD 940	Ask For Quote & Lead Time
25 mg	USD 1880	Ask For Quote & Lead Time
50 mg	USD 3000	Ask For Quote & Lead Time
100 mg	USD 4800	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

818.91

Formula

C₄₁H₄₅F₃N₈O₅S

CAS No.

2446928-30-7

SMILES

N#CC1=C(C(F)(F)F)C=C(N2C(N(C3=CC=C(OCCN4C[C@@H](C)N(CC(NC5=CC=CC(NC6C(NC(CC6)=O)=O)=C5)=O)CC4)C(CC)=C3)C(C)(C)C2=O)=S)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (152.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2211 mL	6.1057 mL	12.2114 mL
5 mM	0.2442 mL	1.2211 mL	2.4423 mL
10 mM	0.1221 mL	0.6106 mL	1.2211 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu S, et al. Abstract ND02: Discovery of BMS-986365, a ligand-directed androgen receptor degrader (AR LDD) with a dual mechanism-of-action and best-in-class potential, for the treatment of advanced prostate cancer[J]. Cancer Research, 2024, 84(7_Supplement): ND02-ND02.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2211 mL	6.1057 mL	12.2114 mL	30.5284 mL
	5 mM	0.2442 mL	1.2211 mL	2.4423 mL	6.1057 mL
	10 mM	0.1221 mL	0.6106 mL	1.2211 mL	3.0528 mL
	15 mM	0.0814 mL	0.4070 mL	0.8141 mL	2.0352 mL
	20 mM	0.0611 mL	0.3053 mL	0.6106 mL	1.5264 mL
	25 mM	0.0488 mL	0.2442 mL	0.4885 mL	1.2211 mL
	30 mM	0.0407 mL	0.2035 mL	0.4070 mL	1.0176 mL
	40 mM	0.0305 mL	0.1526 mL	0.3053 mL	0.7632 mL
	50 mM	0.0244 mL	0.1221 mL	0.2442 mL	0.6106 mL
	60 mM	0.0204 mL	0.1018 mL	0.2035 mL	0.5088 mL
	80 mM	0.0153 mL	0.0763 mL	0.1526 mL	0.3816 mL
	100 mM	0.0122 mL	0.0611 mL	0.1221 mL	0.3053 mL

BMS-986365 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-9863652446928-30-7BMS986365BMS 986365Androgen ReceptorHeterobifunctional ligand-directed degraderLDDin advanced prostate cancerInhibitorinhibitorinhibit

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