Qingdainone
Based on 1 publication(s) in Google Scholar
Qingdainone is a quinazoline alkaloid and also a TMPRSS2 inhibitor. Qingdainone can be isolated from Strobilanthes cusia. Qingdainone exhibits anti-tumor and anti-inflammatory activities. Qingdainone can be used in studies related to chronic myeloid leukemia.
For research use only. We do not sell to patients.
- CAS No.: 97457-31-3
- Formula: C23H13N3O2
- Molecular Weight:363.37
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Qingdainone
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Biological Activity
Qingdainone binds tightly to homology-modeled human TMPRSS2 with a docked binding energy of -9.6 kcal/mol, forming specific hydrogen bonds and hydrophobic interactions with key protein residues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 97457-31-3
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Appearance Solid
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Molecular Weight 363.37
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Formula C23H13N3O2
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Color Brown to black
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SMILES
O=C1C2=CC=CC=C2N/C1=C3C4=CC=CC=C4N5C\3=NC6=CC=CC=C6C5=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Ethnopharmacol
Mechanism of action of Pulsatilla chinensis (Bunge) Regel compounds in hepatocellular carcinoma (HCC) treatment: An integrated analysis combining network pharmacology, molecular docking, molecular dynamics simulations and luciferase reporter gene assay. [Abstract]2025 Aug 29:352:120176. PMID: 40543694
Purity & Documentation
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Data Sheet (278 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Vivek-Ananth RP, et al. In Silico Identification of Potential Natural Product Inhibitors of Human Proteases Key to SARS-CoV-2 Infection. Molecules. 2020 Aug 22;25(17):3822. [Content Brief]
[2]. Li H, et al. Deciphering Key Pharmacological Pathways of Qingdai Acting on Chronic Myeloid Leukemia Using a Network Pharmacology-Based Strategy. Med Sci Monit. 2018 Aug 15;24:5668-5688. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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