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Pathways Recommended: Metabolic Enzyme/Protease
Results for "

deubiquitinating enzyme

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

1

Peptides

48

Recombinant Proteins

2

Isotope-Labeled Compounds

13

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111458
    GSK2643943A
    5+ Cited Publications

    Deubiquitinase Cancer
    GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. GSK2643943A has affinity with an IC50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) .
    GSK2643943A
  • HY-13989
    b-AP15
    Maximum Cited Publications
    12 Publications Verification

    NSC 687852

    Deubiquitinase Apoptosis Cancer
    b-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.
    b-AP15
  • HY-153045
    BAY-805
    3 Publications Verification

    Deubiquitinase Cancer
    BAY-805, a chemical probe, is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes .
    BAY-805
  • HY-D0843S

    NEM-d5

    Cathepsin Deubiquitinase Others
    N-Ethylmaleimide-d5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor . N-ethylmaleimide specific inhibits phosphate transport in mitochondria . N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor .
    N-Ethylmaleimide-d5
  • HY-176426

    Deubiquitinase NF-κB IFNAR Cancer
    Subquinocin is a tumor suppressor CYLD inhibitor that inhibits USP family deubiquitinases (DUBs) activity of CYLD with an IC50 of 30 μM. Subquinocin enhances the activation of NF-κB and IFN pathways by inhibiting CYLD. Subquinocin promotes RIG-I-mediated activation of IRF3/IRF7 in the interferon pathway. Subquinocin can be used for the research of cancer and neurodegenerative diseases .
    Subquinocin
  • HY-139979
    USP5-IN-1
    3 Publications Verification

    Deubiquitinase Cancer
    USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.
    USP5-IN-1
  • HY-50737
    DUB-IN-3
    5+ Cited Publications

    Deubiquitinase Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    DUB-IN-3 (compound 22c) is a potent and selective inhibitor of the deubiquitinating enzyme USP8 with an IC50 value of 0.56 μM. DUB-IN-3 is promising for research of cancer, neurodegenerative diseases, inflammation, viral infection and cardiovascular disease .
    DUB-IN-3
  • HY-136528

    Deubiquitinase Apoptosis Cancer
    RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells .
    RA-9
  • HY-178124

    Deubiquitinase Neurological Disease Cancer
    Huib32 is a potent small-molecule inhibitor of USP32 (IC50 = 21.2 nM), exhibiting high selectivity over other closely related deubiquitinating enzymes (DUBs), such as USP8/10/16, UCHL1 and OTUB2. Huib32 reversibly inhibits USP32 by covalently binding to the active site Cys743, which enhances substrate ubiquitination, alters endosomal morphology, and mimics USP32 depletion. Huib32 can be used for breast, ovarian, and lung cancer and Alzheimer's and Parkinson’s diseases research .
    Huib32
  • HY-P10714

    Proteasome Apoptosis Deubiquitinase Cancer
    Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM .
    Ub4ix
  • HY-179058

    Deubiquitinase Ras Cancer
    JOSD2-IN-1 (Compound 31) is a covalent JOSD2 inhibitor with an IC50 value of 1.95 μM. JOSD2-IN-1 inhibits JOSD2, thereby down-regulating KRAS expression. JOSD2-IN-1 exhibits significant anti-proliferative activity against HCT116 cells. JOSD2-IN-1 can be used for research on colorectal cancer .
    JOSD2-IN-1
  • HY-161446

    Deubiquitinase Cancer
    USP1-IN-7 (Compound 3) is an inhibitor for ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, with IC50 ≤50 nM. USP1-IN-7 inhibits proliferation of MDA-MB-436 with IC50 ≤50 nM .
    USP1-IN-7
  • HY-161447

    Deubiquitinase Cancer
    USP1-IN-8 (Compound 16) is an inhibitor for ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, with IC50 ≤50 nM. USP1-IN-8 inhibits proliferation of MDA-MB-436 with IC50 ≤50 nM .
    USP1-IN-8
  • HY-156001

    Deubiquitinase Cancer
    DUB-IN-7 (compound 43) is a Deubiquitinating enzymes (DUBs) inhibitor. DUB-IN-7 can be used in the study of diseases mediated by dysregulated JAK2 activity, such as leukemia .
    DUB-IN-7
  • HY-E70627

    Deubiquitinase Neurological Disease
    Ubiquitin thiolesterase UCHL1 (EC 3.1.2.15) is a member of the ubiquitin carboxy-terminal hydrolase family of deubiquitinating enzymes. Ubiquitin thiolesterase UCHL1 functions as an ubiquitin ligase and a mono-ubiquitin stabilizer .
    Ubiquitin thiolesterase UCHL1
  • HY-15432

    (E/Z)-b-AP15

    Deubiquitinase Cancer
    (E/Z)-NSC-687852 is a isomer of NSC-687852 (HY-13989). NSC687852 (b-AP15) is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14 .
    (E/Z)-NSC-687852
  • HY-175934

    Deubiquitinase Cancer
    MS5105 is a covalent ligand of the deubiquitinating enzyme OTUB1, which can be used to construct DUBTACs, such as MS8588 (HY-162967) .
    MS5105

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