USP9Y Protein, Human
The USP9Y protein is a multifunctional ubiquitin proteolytic enzyme that performs critical processing of ubiquitin precursors and ubiquitinated proteins. Its multifaceted roles make USP9Y a key regulator of protein turnover, preventing degradation by efficiently removing the ubiquitin moiety. USP9Y Protein, Human is the recombinant human-derived USP9Y protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
The USP9Y protein is a multifunctional ubiquitin proteolytic enzyme that performs critical processing of ubiquitin precursors and ubiquitinated proteins. Its multifaceted roles make USP9Y a key regulator of protein turnover, preventing degradation by efficiently removing the ubiquitin moiety. USP9Y Protein, Human is the recombinant human-derived USP9Y protein, expressed by E. coli , with tag free.
The USP9Y Protein emerges as a versatile ubiquitin-protein or polyubiquitin hydrolase, playing a crucial role in the processing of both ubiquitin precursors and ubiquitinated proteins. This multifaceted function positions USP9Y as a key regulator in protein turnover, where it prevents the degradation of proteins by efficiently removing conjugated ubiquitin moieties. Additionally, USP9Y serves as an essential component within the TGF-beta/BMP signaling cascade. Notably, it acts as a deubiquitinase for monoubiquitinated SMAD4, countering the activity of the E3 ubiquitin-protein ligase TRIM33. This deubiquitination process restores the competency of SMAD4 to form a stable complex with activated SMAD2/3, thereby facilitating the unhindered progression of the TGF-beta/BMP signaling cascade. In essence, USP9Y's regulatory prowess emerges as a critical factor in orchestrating the dynamic balance of protein degradation and signaling within the cellular landscape.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
O00507 (R1553-S1972)
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Gene ID8287
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Molecular Construction
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N-term
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USP9Y (R1553-S1972)
Accession # O00507 -
C-term
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Protein Length
Partial
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Synonyms
USP9Y; Ubiquitin Specific Peptidase 9 Y‑Linked; DFFRY; FAF‑Y; Ubiquitin Specific Peptidase 9, Y‑Linked (Fat Facets‑Like, Drosophila); Ubiquitin‑Specific Protease 9, Y Chromosome; Ubiquitin Carboxyl‑Terminal Hydrolase 9Y; Fat Facets Protein‑Related, Y‑Link
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AA Sequence
RPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNSILAIEGTGSDLHDDMFGDEKQDSESNVDPRDDVFGYPHQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASQLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAILSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYIKGDLLEGANAYHCEKCDKKVDTVKRLLIKKLPRVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMGPYTVAGVANLERDNVNSENELIEQKEQSDNETAGGTKYRLVGVLVHSGQASGGHYYSYIIQRNGKDDQTDHWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYEQMDMIDEDDEMIRYIS
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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