USP9Y Protein, Human (GST)

The USP9Y protein is a multifunctional ubiquitin proteolytic enzyme that performs critical processing of ubiquitin precursors and ubiquitinated proteins. Its multifaceted roles make USP9Y a key regulator of protein turnover, preventing degradation by efficiently removing the ubiquitin moiety. USP9Y Protein, Human (GST) is the recombinant human-derived USP9Y protein, expressed by E. coli , with N-GST labeled tag. The total length of USP9Y Protein, Human (GST) is 420 a.a., .

The USP9Y Protein emerges as a versatile ubiquitin-protein or polyubiquitin hydrolase, playing a crucial role in the processing of both ubiquitin precursors and ubiquitinated proteins. This multifaceted function positions USP9Y as a key regulator in protein turnover, where it prevents the degradation of proteins by efficiently removing conjugated ubiquitin moieties. Additionally, USP9Y serves as an essential component within the TGF-beta/BMP signaling cascade. Notably, it acts as a deubiquitinase for monoubiquitinated SMAD4, countering the activity of the E3 ubiquitin-protein ligase TRIM33. This deubiquitination process restores the competency of SMAD4 to form a stable complex with activated SMAD2/3, thereby facilitating the unhindered progression of the TGF-beta/BMP signaling cascade. In essence, USP9Y's regulatory prowess emerges as a critical factor in orchestrating the dynamic balance of protein degradation and signaling within the cellular landscape.

Human

E. coli

N-GST

O00507 (R1553-S1972)

8287

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.