USP46 Protein, Human/Mouse (sf9, SUMO)
USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9, SUMO) is the recombinant mouse-derived USP46 protein, expressed by Sf9 insect cells , with SUMO labeled tag.
- Species: Mouse
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9, SUMO) is the recombinant mouse-derived USP46 protein, expressed by Sf9 insect cells , with SUMO labeled tag.
Background
USP46 protein, a deubiquitinating enzyme, is implicated in behavioral regulation, potentially through the modulation of GABA action. Its role may involve mediating the deubiquitination of GAD1/GAD67, as suggested by studies. Interestingly, USP46 exhibits minimal deubiquitinating activity on its own and relies on interaction with WDR48 to achieve high enzymatic activity. Contrary to its involvement in GABA-related processes, USP46 is not engaged in the deubiquitination of monoubiquitinated FANCD2, indicating specificity in its substrate interactions (By similarity). This multifaceted enzyme sheds light on the intricate regulatory mechanisms underlying behavior and neurotransmitter dynamics.
Technical Parameters
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Species Mouse
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Source Sf9 insect cells
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Tag SUMO
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Accession
P62069 (M1-E366)
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Protein Length
Full Length
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Synonyms
USP46; Ubiquitin Specific Peptidase 46; Ubiquitin-Specific-Processing Protease 46; Ubiquitin Carboxyl-Terminal Hydrolase 46; Deubiquitinating Enzyme 46; Ubiquitin Thioesterase 46; FLJ12552; Ubiquitin Specific Protease 46; Ubiquitin Thiolesterase 46; Alter
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AA Sequence
MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE
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Predicted Molecular Mass
55.2 kDa
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Molecular Weight
Approximately 64 Kda, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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