USP46 Protein, Human/Mouse (sf9, SUMO)

USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9, SUMO) is the recombinant mouse-derived USP46 protein, expressed by Sf9 insect cells , with SUMO labeled tag.

USP46 protein, a deubiquitinating enzyme, is implicated in behavioral regulation, potentially through the modulation of GABA action. Its role may involve mediating the deubiquitination of GAD1/GAD67, as suggested by studies. Interestingly, USP46 exhibits minimal deubiquitinating activity on its own and relies on interaction with WDR48 to achieve high enzymatic activity. Contrary to its involvement in GABA-related processes, USP46 is not engaged in the deubiquitination of monoubiquitinated FANCD2, indicating specificity in its substrate interactions (By similarity). This multifaceted enzyme sheds light on the intricate regulatory mechanisms underlying behavior and neurotransmitter dynamics.

Mouse

Sf9 insect cells

SUMO

P62069 (M1-E366)

69727  [NCBI]

Full Length

MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE

Approximately 64 Kda, based on SDS-PAGE under reducing conditions, due to the glycosylation.

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.