Usp46 - ubiquitin specific peptidase 46 Gene

Also Known as 1190009E20Rik; 2410018I08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69727

Summary

Enables Deubiquitinase activity. Involved in regulation of GABAergic synaptic transmission. Acts upstream of or within several processes, including adult feeding behavior; behavioral fear response; and behavioral response to ethanol. Predicted to be active in cytosol and nucleus. Is expressed in pancreas epithelium. Orthologous to human USP46 (ubiquitin specific peptidase 46). [provided by Alliance of Genome Resources, Apr 2022]

Usp46 Products (1)

mRNA Protein Name
NM_177561.3 NP_808229.1 ubiquitin carboxyl-terminal hydrolase 46

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables deubiquitinase activity IDA
IDA: Inferred from direct assay
26811477 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult feeding behavior IMP
IMP: Inferred from mutant phenotype
23472206 MGI
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
22720038 MGI
acts upstream of or within behavioral response to ethanol IMP
IMP: Inferred from mutant phenotype
23472206 MGI
acts upstream of or within protein deubiquitination IDA
IDA: Inferred from direct assay
26811477 MGI
involved in regulation of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
19465912 MGI
acts upstream of or within righting reflex IMP
IMP: Inferred from mutant phenotype
23472206 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 46

  • deubiquitinating enzyme 46

  • ubiquitin specific protease 46

  • ubiquitin thioesterase 46

  • ubiquitin thiolesterase 46

  • ubiquitin-specific-processing protease 46

Recombinant Usp46 Proteins

Cat. No. Product Name Accession Purity
HY-P77277 USP46 Protein, Human/Mouse (sf9) P62069 (M1-E366) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P77278 USP46 Protein, Human/Mouse (sf9, SUMO) P62069 (M1-E366) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS24179 Usp46 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15557 USP46 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17714 Usp46 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Usp46 NCBI NCBI:64854