USP46 Protein, Human/Mouse (sf9)
Based on 1 Customer Validation
USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9) is the recombinant human, mouse-derived USP46 protein, expressed by Sf9 insect cells , with tag free.
- Species: Human; Mouse
- Source: Sf9 insect cells
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9) is the recombinant human, mouse-derived USP46 protein, expressed by Sf9 insect cells , with tag free.
USP46 protein, a deubiquitinating enzyme, is implicated in behavioral regulation, potentially through the modulation of GABA action. Its role may involve mediating the deubiquitination of GAD1/GAD67, as suggested by studies. Interestingly, USP46 exhibits minimal deubiquitinating activity on its own and relies on interaction with WDR48 to achieve high enzymatic activity. Contrary to its involvement in GABA-related processes, USP46 is not engaged in the deubiquitination of monoubiquitinated FANCD2, indicating specificity in its substrate interactions (By similarity). This multifaceted enzyme sheds light on the intricate regulatory mechanisms underlying behavior and neurotransmitter dynamics.
Technical Parameters
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Species Human; Mouse
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Source Sf9 insect cells
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Tag Tag Free
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Accession
P62069 (M1-E366)
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Molecular Construction
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N-term
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USP46 (M1-E366)
Accession # P62069 -
C-term
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Protein Length
Full Length
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Synonyms
USP46; Ubiquitin Specific Peptidase 46; Ubiquitin‑Specific‑Processing Protease 46; Ubiquitin Carboxyl‑Terminal Hydrolase 46; Deubiquitinating Enzyme 46; Ubiquitin Thioesterase 46; FLJ12552; Ubiquitin Specific Protease 46; Ubiquitin Thiolesterase 46; Alter
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AA Sequence
MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE
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Predicted Molecular Mass
42.4 kDa
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Molecular Weight
Approximately 43 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10% Glycerol, 5% trehalose, 5% mannitol and 0.01% Tween 80.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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