USP46 Protein, Human (His, GST)
USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human (His, GST) is the recombinant human-derived USP46 protein, expressed by E. coli , with N-6*His, N-GST labeled tag.
- Species: Human
- Source: E. coli
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human (His, GST) is the recombinant human-derived USP46 protein, expressed by E. coli , with N-6*His, N-GST labeled tag.
Background
USP46 is identified as a behaviorally relevant deubiquitinating enzyme, potentially influencing behavior through the regulation of GABAergic neurotransmission. Its role is suggested to involve mediating the deubiquitination of GAD1/GAD67, crucial in GABA synthesis. Remarkably, USP46 exhibits minimal deubiquitinating activity independently, necessitating interaction with WDR48 for substantial enzymatic function. This intricate partnership with WDR48 highlights the collaborative nature of its enzymatic activity. Notably, USP46 does not participate in the deubiquitination of monoubiquitinated FANCD2, indicating specificity in its cellular functions.
Technical Parameters
-
Species Human
-
Source E. coli
-
Tag N-6*His;N-GST
-
Accession
P62068 (M1-E366)
-
Gene ID64854
-
Molecular Construction
-
N-term
-
6*His-GST
-
USP46 (M1-E366)
Accession # P62068 -
C-term
-
-
Protein Length
Full Length
-
Synonyms
USP46; Ubiquitin Specific Peptidase 46; Ubiquitin-Specific-Processing Protease 46; Ubiquitin Carboxyl-Terminal Hydrolase 46; Deubiquitinating Enzyme 46; Ubiquitin Thioesterase 46; FLJ12552; Ubiquitin Specific Protease 46; Ubiquitin Thiolesterase 46; Alter
-
AA Sequence
MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE
-
Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
