USP46 Protein, Human (His, GST)

USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human (His, GST) is the recombinant human-derived USP46 protein, expressed by E. coli , with N-6*His, N-GST labeled tag.

USP46 is identified as a behaviorally relevant deubiquitinating enzyme, potentially influencing behavior through the regulation of GABAergic neurotransmission. Its role is suggested to involve mediating the deubiquitination of GAD1/GAD67, crucial in GABA synthesis. Remarkably, USP46 exhibits minimal deubiquitinating activity independently, necessitating interaction with WDR48 for substantial enzymatic function. This intricate partnership with WDR48 highlights the collaborative nature of its enzymatic activity. Notably, USP46 does not participate in the deubiquitination of monoubiquitinated FANCD2, indicating specificity in its cellular functions.

Human

E. coli

N-6*His;N-GST

P62068 (M1-E366)

64854

Full Length

MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE

≥ 80%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. /biology-dictionary/mcf7-cell.html  [Content Brief]