USP51 Protein, Human (sf9)
The USP51 protein uniquely regulates the DNA damage response by deubiquitinating the "Lys-14" (H2AK13Ub) and "Lys-16" (H2AK15Ub) residues of histone H2A at double-strand breaks. After DNA damage, USP51 is recruited to chromatin and regulates TP53BP1 and BRCA1 assembly/disassembly, which is critical for DNA repair. USP51 Protein, Human (sf9) is the recombinant human-derived USP51 protein, expressed by sf9 insect cells , with tag free.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The USP51 protein uniquely regulates the DNA damage response by deubiquitinating the "Lys-14" (H2AK13Ub) and "Lys-16" (H2AK15Ub) residues of histone H2A at double-strand breaks. After DNA damage, USP51 is recruited to chromatin and regulates TP53BP1 and BRCA1 assembly/disassembly, which is critical for DNA repair. USP51 Protein, Human (sf9) is the recombinant human-derived USP51 protein, expressed by sf9 insect cells , with tag free.
Background
USP51 protein plays a distinctive role in the regulation of the DNA damage response by specifically deubiquitinating 'Lys-14' (H2AK13Ub) and 'Lys-16' (H2AK15Ub) residues of histone H2A at double-strand breaks (DSBs). Following DNA damage, USP51 is recruited to chromatin, where it actively modulates the dynamic assembly and disassembly of TP53BP1 and BRCA1, crucial players in DNA repair processes. In addition to its role in histone H2A deubiquitination, USP51 exhibits activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin, further expanding its impact on the ubiquitin signaling pathway. The intricate involvement of USP51 in these molecular processes underscores its significance in orchestrating the DNA damage response and highlights its potential as a key player in maintaining genomic integrity.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag Tag Free
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Accession
Q70EK9 (R363-Q706)
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Gene ID158880
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Molecular Construction
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N-term
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USP51 (R363-Q706)
Accession # Q70EK9 -
C-term
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Protein Length
Full Length of USP Domain
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Synonyms
USP51; Ubiquitin Specific Peptidase 51; Ubiquitin-Specific-Processing Protease 51; Ubiquitin Carboxyl-Terminal Hydrolase 51; Deubiquitinating Enzyme 51; Ubiquitin Thioesterase 51; Ubiquitin Carboxyl-Terminal Hydrolase; Ubiquitin Specific Protease 51; Ubiq
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AA Sequence
RGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRHSKDDSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLYSEGYLLFYHKQ
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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