OTUB2 Protein, Human (GST)
OTUB2 is a hydrolase that efficiently removes conjugated ubiquitin from proteins in vitro, implying a crucial role in preventing protein degradation and regulating turnover. Its deubiquitinating activity targets “Lys-11”, “Lys-48” and “Lys-63” linked polyubiquitin chains, with preference for the latter. OTUB2 Protein, Human (GST) is the recombinant human-derived OTUB2 protein, expressed by E. coli , with N-GST labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
OTUB2 is a hydrolase that efficiently removes conjugated ubiquitin from proteins in vitro, implying a crucial role in preventing protein degradation and regulating turnover. Its deubiquitinating activity targets “Lys-11”, “Lys-48” and “Lys-63” linked polyubiquitin chains, with preference for the latter. OTUB2 Protein, Human (GST) is the recombinant human-derived OTUB2 protein, expressed by E. coli , with N-GST labeled tag.
As a hydrolase, OTUB2 exhibits the capacity to efficiently remove conjugated ubiquitin from proteins in vitro, suggesting a pivotal regulatory role in protein turnover by preventing degradation. With its deubiquitination activity, OTUB2 acts on 'Lys-11', 'Lys-48', and 'Lys-63'-linked polyubiquitin chains, displaying a preference for the latter. This specificity underscores OTUB2's selectivity in modulating diverse ubiquitin linkages, emphasizing its potential significance in orchestrating cellular processes related to protein ubiquitination and degradation.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-GST
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Accession
Q96DC9-1 (M1-H234)
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Molecular Construction
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N-term
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GST
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OTUB2 (M1-H234)
Accession # Q96DC9-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
OTUB2; Otubain-2; Prev. C14orf137; MGC3102; OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 2; OTB2; Ubiquitin-Specific-Processing Protease OTUB2; OTU2; OTU Domain, Ubiquitin Aldehyde Binding 2; Ubiquitin-Specific Protease Otubain 2; Deubiquitina
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AA Sequence
MSETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNCFYRALGYSYLESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDTALNHHVFPEAATPSVYLLYKTSHYNILYAADKH
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Predicted Molecular Mass
53.6 kDa
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Molecular Weight
Approximately 52 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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