OTUB2 - OTU deubiquitinase, ubiquitin aldehyde binding 2 Gene

Also Known as OTB2; OTU2; C14orf137

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 78990

About OTUB2

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:94,026,340-94,048,930 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 167 orthologues and 1 paralogue. Broad expression in testis (RPKM 3.4), skin (RPKM 2.0) and 18 other tissues.

Summary

This gene encodes one of several deubiquitylating Enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling Enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]

OTUB2 Products (1)

mRNA Protein Name
NM_023112.4 NP_075601.1 ubiquitin thioesterase OTUB2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
18954305 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
15258613 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in protein K11-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
18954305 GOA
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
18954305 GOA
involved in protein deubiquitination IMP
IMP: Inferred from mutant phenotype
15258613 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTUB2 Protein Structure

Peptidase_C65

Peptidase_C65: Peptidase C65 Otubain (2 - 229)

  • 0
  • 100
  • 200
  • 234 a.a.
Protein Preferred Names Protein Names

ubiquitin thioesterase OTUB2

  • OTU domain, ubiquitin aldehyde binding 2

OTUB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
OTUB2 Q96DC9 MID2 Homo sapiens Q9UJV3-2
Y2H Array
25416956
Intra
OTUB2 Q96DC9 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
OTUB2 Q96DC9 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
OTUB2 Q96DC9 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 FAM168A Homo sapiens Q92567-2
Y2H Array
32296183
Intra
OTUB2 Q96DC9 FAM168A Homo sapiens Q92567-2
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 PMEPA1 Homo sapiens Q969W9-2
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 PMEPA1 Homo sapiens Q969W9-2
Y2H Array
32296183
Intra
OTUB2 Q96DC9 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
Intra
OTUB2 Q96DC9 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra
OTUB2 Q96DC9 MID1 Homo sapiens O15344
Y2H Prey Pooling
25416956
Intra
OTUB2 Q96DC9 TRIM8 Homo sapiens Q9BZR9
Y2H Array
32296183
Intra
OTUB2 Q96DC9 TRIM8 Homo sapiens Q9BZR9
Validated Y2H
32296183
Intra
OTUB2 Q96DC9 TRIM8 Homo sapiens Q9BZR9
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 SPART Homo sapiens Q8N0X7
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 SPART Homo sapiens Q8N0X7
Y2H Array
32296183
Intra
OTUB2 Q96DC9 ARRDC3 Homo sapiens Q96B67
Validated Y2H
25416956
Intra
OTUB2 Q96DC9 ARRDC3 Homo sapiens Q96B67
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 ARRDC3 Homo sapiens Q96B67
Y2H Array
25416956
Intra
OTUB2 Q96DC9 ARRDC3 Homo sapiens Q96B67
Y2H Array
32296183
Intra
OTUB2 Q96DC9 CDIP1 Homo sapiens Q9H305
Validated Y2H
32296183
Intra
OTUB2 Q96DC9 CDIP1 Homo sapiens Q9H305
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 CDIP1 Homo sapiens Q9H305
Y2H Array
32296183
Intra
OTUB2 Q96DC9 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
OTUB2 Q96DC9 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
OTUB2 Q96DC9 CPSF6 Homo sapiens Q16630
Validated Y2H
25416956
Intra
OTUB2 Q96DC9 CPSF6 Homo sapiens Q16630
Y2H Prey Pooling
25416956
Intra
OTUB2 Q96DC9 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra
OTUB2 Q96DC9 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
32296183
Intra
OTUB2 Q96DC9 MKRN1 Homo sapiens Q9UHC7
Validated Y2H
32296183
Intra
OTUB2 Q96DC9 MKRN1 Homo sapiens Q9UHC7
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 MKRN1 Homo sapiens Q9UHC7
Y2H Array
32296183
Intra
OTUB2 Q96DC9 PLEKHB2 Homo sapiens Q96CS7
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 PLEKHB2 Homo sapiens Q96CS7
Y2H Array
32296183
Intra
OTUB2 Q96DC9 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
OTUB2 Q96DC9 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
OTUB2 Q96DC9 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra
OTUB2 Q96DC9 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
OTUB2 Q96DC9 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
Intra
OTUB2 Q96DC9 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra
OTUB2 Q96DC9 FAM168A Homo sapiens Q92567
Y2H Array
31515488
Intra
OTUB2 Q96DC9 FAM168A Homo sapiens Q92567
Y2H Prey Pooling
25416956
Intra
OTUB2 Q96DC9 FAM168A Homo sapiens Q92567
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OTUB2 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71182 OTUB2 Protein, Human (GST) Q96DC9-1 (M1-H234) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77118 OTUB2 Protein, Human (His) Q96DC9-1 (M1-H234) ≥ 95%, as determined by reducing SDS-PAGE.

OTUB2 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P84723 OTUB2 Antibody (YA4420) WB, FC, ELISA Human
HY-P84723A OTUB2 Antibody (YA4420)(PBS only) WB, FC, ELISA Human
HY-P84724 OTUB2 Antibody (YA4421) ICC/IF, FC, ELISA Human
HY-P84724A OTUB2 Antibody (YA4421)(PBS only) ICC/IF, FC, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-160768 OTUB2-IN-1 Inhibitor 98.79% Unkown
HY-149482 LN5P45 Inhibitor 98.68% Unkown
HY-178124 Huib32 Inhibitor 98.72% Unkown
HY-RS09870 OTUB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19026 Otub2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25515 Otub2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus OTUB2 VGNC VGNC:32492
Mus musculus OTUB2 MGD MGI:1915399
Macaca mulatta OTUB2 VGNC VGNC:75656
Rattus norvegicus OTUB2 RGD RGD:1306688
Felis catus OTUB2 VGNC VGNC:80887
Canis familiaris OTUB2 VGNC VGNC:44183
Others OTUB2 NCBI