USP6 Protein, Human (sf9)
USP6 protein is an ATP-independent isopeptidase with unique deubiquitinase activity that can cleave the C-terminus of ubiquitin and catalyze its own deubiquitination. Notably, it coordinates ARF6 plasma membrane localization and selectively affects ARF6-dependent endocytic protein trafficking. USP6 Protein, Human (sf9) is the recombinant human-derived USP6 protein, expressed by sf9 insect cells , with tag free.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
USP6 protein is an ATP-independent isopeptidase with unique deubiquitinase activity that can cleave the C-terminus of ubiquitin and catalyze its own deubiquitination. Notably, it coordinates ARF6 plasma membrane localization and selectively affects ARF6-dependent endocytic protein trafficking. USP6 Protein, Human (sf9) is the recombinant human-derived USP6 protein, expressed by sf9 insect cells , with tag free.
USP6, an ATP-independent isopeptidase, possesses distinctive deubiquitinase activity, cleaving at the C-terminus of the ubiquitin moiety and catalyzing its own deubiquitination. In vitro, isoform 2 exhibits deubiquitinating activity, contrasting with isoform 3. Notably, USP6 plays a crucial role in orchestrating plasma membrane localization of ARF6 and selectively modulating ARF6-dependent endocytic protein trafficking. Its functional significance extends to tumorigenesis initiation, as it induces the production of matrix metalloproteinases through NF-kappa-B activation. USP6's multifaceted activity highlights its pivotal role in cellular processes, positioning it as a key player in protein regulation, membrane dynamics, and the intricate balance involved in tumorigenesis.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag Tag Free
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Accession
P35125 (K529-Q1406)
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Gene ID9098
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Molecular Construction
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N-term
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USP6 (K529-Q1406)
Accession # P35125 -
C-term
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Protein Length
Partial
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Synonyms
USP6; Ubiquitin Specific Peptidase 6; HRP1; TRESMCR; Ubiquitin Carboxyl‑Terminal Hydrolase 6; Tre‑2; TRE17; Tre2; Ubiquitin Specific Peptidase 6 (Tre‑2 Oncogene); Ubiquitin Specific Protease 6 (Tre‑2 Oncogene); Ubiquitin‑Specific‑Processing Protease 6; De
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AA Sequence
KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQKVQLSVSGFLCAFEIPVPSSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMRTELYFLSPQENRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSWLARPLPPQEASIHAQDRDNCMGYQYPFTLRVVQKDGNSCAWCPQYRFCRGCKIDCGEDRAFIGNAYIAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVRFLRESFDPSAFLVPRDPALCQHKPLTPQGDELSKPRILAREVKKVDAQSSAGKEDMLLSKSPSSLSANISSSPKGSPSSSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKPSSSKKNLDASKENGAGQICELADALSRGHMRGGSQPELVTPQDHEVALANGFLYEHEACGNGCGDGYSNGQLGNHSEEDSTDDQREDTHIKPIYNLYAISCHSGILSGGHYITYAKNPNCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQGIDYAQFLPKIDGKKMADTSSTDEDSESDYEKYSMLQ
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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