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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
94 Results for "
human erythrocytes
" in MedChemExpress (MCE) Product Catalog:
Products (94)
94 Results for "human erythrocytes" in MCE Product Catalog:
29
Category:
Rosaceae Plants Dihydrochalcones Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Malus pumila Mill. Phenols Polyphenols Disease Research Fields Cancer
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10
10 Cited Publications
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G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH). G6PD activator AG1 can reduce hemolysis of human erythrocytes .
7
7 Cited Publications
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DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ～0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9 .
3
3 Cited Publications
Synonyms: Chlorguanide triazine hydrochloride
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Cycloguanil (Chlorguanide triazine) hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .
2
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Acetohexamide is an orally active first-generation sulfonylurea agent used in research related to type 2 diabetes and cancer. Acetohexamide exerts reductase activity in human erythrocytes. Acetohexamide stimulates the pancreas to secrete insulin. Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. Acetohexamide can inhibit the formation of circular chemorepellent induced defects (CCIDs) in lymphendothelial cell (LEC) monolayers. Acetohexamide inhibits markers of epithelial-to-mesenchymal-transition and migration. Acetohexamide suppresses the synthesis of 12(S)-HETE. Acetohexamide can potentiate hypoglycaemic action .
1
1 Cited Publications
Cat. No.: HY-P1856
CAS No.: 33017-11-7
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Cardiovascular Disease Metabolic Disease Inflammation/Immunology
1
1 Cited Publications
Cat. No.: HY-W035091
CAS No.: 16903-35-8
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Tetrachloroauric acid is an Au (III) compound and bilayer disruptor that can be used to damage red blood cells. Tetrachloroauric acid specifically disrupts the bilayer structure of representative phospholipids (dimyristoylphosphatidylcholine and dimyristoylphosphatidylethanolamine) in human red blood cell membranes, and induces morphological changes in intact human red blood cells. Tetrachloroauric acid causes downregulation of MT I-II and GFAP expression in the mouse brain following chronic treatment. Tetrachloroauric acid is being used in studies related to neurotoxicity and hematotoxicity, including analyses of human red blood cells and molecular models of red blood cell membranes, as well as immunohistochemical evaluation of the mouse brain .
1
1 Cited Publications
Cat. No.: HY-P2460
CAS No.: 172485-26-6
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1
1 Cited Publications
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AZD2906 is a selective glucocorticoid receptor (GR) agonist, increases micronucleated immature erythrocytes in the bone marrow of rats. AZD2906 shows IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively .
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Edrophonium chloride is a short-acting acetylcholinesterase (AChE) inhibitor. Edrophonium chloride has Ki values of 0.2, 0.2, and 0.4 μM and IC50 values of 0.2, 0.05, and 0.5 μM for AChE in human erythrocytes, purified calf forebrain, and purified octopus brain, respectively. Edrophonium chloride can be used to detect early digitalis toxicity and in the study of myasthenia gravis .
Cat. No.: HY-P99232
CAS No.: 1497400-26-6
Synonyms: 5F9 Monoclonal antibody; TAK-164 Antibody
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Cat. No.: HY-W008344
CAS No.: 146-77-0
Research Areas:
Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer
2-Chloroadenosine is an adenosine analog, a transporter permeabilizer of nucleoside transporters, and a competitive uridine influx inhibitor (apparent Ki=33 μM). 2-Chloroadenosine binds to nitrobenzylthioinosine with high affinity (apparent Ki=0.18 mM). 2-Chloroadenosine promotes Apoptosis and increases cerebral blood flow. 2-Chloroadenosine has anticonvulsant properties. 2-Chloroadenosine is used to study infection, inflammatory diseases, cancer, blood-related diseases, lung injury, epilepsy, and kidney disease .
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Pyrroline-5-carboxylate sodium is a key intermediate in proline anabolism and catabolism. Pyrroline-5-carboxylate sodium plays important roles in plant defense against pathogen invasion, as well as in redox regulation, nucleotide synthesis and other processes in animal cells .
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Biocytin hydrazide is a long-chain biotin-containing hydrazide, serving as a biotin-derived active coupling reagent, selective labeling agent and biotinylating reagent. Biocytin hydrazide targets aldehyde, carboxyl, amino and guanidino groups to biotinylate glycoconjugates, K99 lectin, peptides and proteins through its hydrazide moiety, and achieves nonradioactive detection of sialic acid- and galactose-containing glycoconjugates via the avidin–biotin system .
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Cardiovascular Disease Digitalis purpurea Linn. Scrophulariaceae Plants Disease Research Fields Steroids
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Cat. No.: HY-P11292
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Cat. No.: HY-NP070
Synonyms: LTL
Synonyms: EMD-15700
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Nitrefazole (EMD-15700) is an aldehyde dehydrogenase (ALDH) inhibitor. Nitrefazole specifically inhibits human liver ALDH I and human erythrocyte ALDH isozymes, but does not alter the activity of human liver ALDH II or human placental ALDH. Nitrefazole effectively promotes exosome secretion in prostate cancer cells by increasing the levels of Alix, nSMase2, Rab27a and p-ERK . Nitrefazole can be used in studies related to prostate cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
