Glochidioboside 

Glochidioboside, a neolignan glucoside found in Sambucus williamsii, is an antifungal agent. Glochidioboside induces membrane depolarization, membrane permeabilization, and pore formation on fungal membranes. Glochidioboside exerts an antifungal activity through a membrane-disruptive mechanism^[1].

Glochidioboside (3.3-6.5 μg/mL; 48 h) inhibits the growth of Candida albicans (ATCC 90028), Trichosporon beigelii (KCTC 7707), and Malassezia furfur (KCTC 7744) with an MIC of 6.5 μg/mL, and Candida parapsilosis (ATCC 22019) with an MIC of 3.3 μg/mL^[1].
Glochidioboside (50 μM; 1 h) exhibits no hemolytic activity against human erythrocytes^[1].
Glochidioboside (6.5 μg/mL; 4 h) dissipates the cytoplasmic membrane potential of Candida albicans (ATCC 90028) cells, causing membrane depolarization and increases membrane permeability^[1].
Glochidioboside (6.5-26.0 μg/mL; 10 min) induces dose-dependent calcein leakage from large unilamellar vesicles, with 33.8% leakage at 6.5 μg/mL, indicating pore-forming activity in membranes modeled after Candida albicans^[1].
Glochidioboside (6.5 μg/mL; 4 h) causes shrinkage of 18.0% of Candida albicans (ATCC 90028) cells, likely due to membrane damage-induced disruption of electrochemical gradients^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

522.54

C₂₆H₃₄O₁₁

220745-70-0

OC[C@H]1C2=CC(CCCO[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=CC(OC)=C2O[C@@H]1C4=CC(OC)=C(C=C4)O

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lee H, et al. Antifungal effect and mode of action of glochidioboside against Candida albicans membranes. Biochem Biophys Res Commun. 2014;444(1):30-35.  [Content Brief]