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Cat. No.: HY-N19777

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Glochidioboside

Glochidioboside, a neolignan glucoside found in Sambucus williamsii, is an antifungal agent. Glochidioboside induces membrane depolarization, membrane permeabilization, and pore formation on fungal membranes. Glochidioboside exerts an antifungal activity through a membrane-disruptive mechanism.

For research use only. We do not sell to patients.

CAS No.: 220745-70-0
Formula: C₂₆H₃₄O₁₁
Molecular Weight:522.54

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Please store the product under the recommended conditions in the Certificate of Analysis.

Glochidioboside Chemical Structure

CAS No.: 220745-70-0

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

In Vitro

Glochidioboside (3.3-6.5 μg/mL; 48 h) inhibits the growth of Candida albicans (ATCC 90028), Trichosporon beigelii (KCTC 7707), and Malassezia furfur (KCTC 7744) with an MIC of 6.5 μg/mL, and Candida parapsilosis (ATCC 22019) with an MIC of 3.3 μg/mL^[1].
Glochidioboside (50 μM; 1 h) exhibits no hemolytic activity against human erythrocytes^[1].
Glochidioboside (6.5 μg/mL; 4 h) dissipates the cytoplasmic membrane potential of Candida albicans (ATCC 90028) cells, causing membrane depolarization and increases membrane permeability^[1].
Glochidioboside (6.5-26.0 μg/mL; 10 min) induces dose-dependent calcein leakage from large unilamellar vesicles, with 33.8% leakage at 6.5 μg/mL, indicating pore-forming activity in membranes modeled after Candida albicans^[1].
Glochidioboside (6.5 μg/mL; 4 h) causes shrinkage of 18.0% of Candida albicans (ATCC 90028) cells, likely due to membrane damage-induced disruption of electrochemical gradients^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 220745-70-0
Molecular Weight 522.54
Formula C₂₆H₃₄O₁₁
SMILES

OC[C@H]1C2=CC(CCCO[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=CC(OC)=C2O[C@@H]1C4=CC(OC)=C(C=C4)O
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
- Plants
- Viburnaceae
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lee H, et al. Antifungal effect and mode of action of glochidioboside against Candida albicans membranes. Biochem Biophys Res Commun. 2014;444(1):30-35. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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