rel-(E)-6,7-Transdihydroxyligustilide
rel-(E)-6,7-Transdihydroxyligustilide is a compound found in the dried tuberous roots of Polygonum multiflorum. rel-(E)-6,7-Transdihydroxyligustilide inhibits Ca2+‑ATPase in calmodulin-deficient human erythrocyte membranes. rel-(E)-6,7-Transdihydroxyligustilide is used for the research of hyperlipidemia.
For research use only. We do not sell to patients.
- CAS No.: 162426-22-4
- Formula: C12H16O4
- Molecular Weight:224.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
rel-(E)-6,7-Transdihydroxyligustilide (compound 3) (1 h) inhibits calmodulin-deficient human erythrocyte Ca2+-ATPase with an IC50 of 260 μM; it also induces concentration-dependent inhibition of Mg2+-ATPase and Ca2+-ATPase in the same membrane preparation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 162426-22-4
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Molecular Weight 224.25
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Formula C12H16O4
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SMILES
O[C@H]1C2=C(CC[C@@H]1O)/C(OC2=O)=C\CCC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
rel-(E)-6,7-Transdihydroxyligustilide Related Classifications
HY-N18114 Related Classifications
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