Novel Ca(2+)-ATPase inhibitors from the dried root tubers of Polygonum Multiflorum

  • J Nat Prod. 1994 Dec;57(12):1682-7. doi: 10.1021/np50114a010.
J N Grech  1 ,  Q Li ,  B D Roufogalis ,  C C Duck
Affiliations
  • 1. Department of Pharmacy, University of Sydney, New South Wales, Australia.
PMID: 7714535 DOI: 10.1021/np50114a010
Abstract

The MeOH extract of the dried root tubers of Polygonum multiflorum yielded three bioactive compounds with an inhibitory activity on calmodulin-depleted erythrocyte calcium-dependent ATPase. These compounds were identified as E-2,3,5,4'-tetrahydroxystilbene 2-O-beta-D-glucopyranoside [2] (IC50 = 240 microM) and cis- and trans-E-3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)- isobenzofuranone [3 and 4](IC50 = 160 and 260 microM, respectively). E-2,4,6,4'-Tetrahydroxystilbene 2-O-beta-D-glucopyranoside [1] was also isolated but was found to have no inhibitory effect on the enzyme.

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