2. Immunology/Inflammation
  3. COX
  4. AS1-6

AS1-6 is a selective COX-2 inhibitor with an IC50 of 2.7 μM. AS1-6 has an IC50 of 12.6 μM for COX-1. AS1-6 exerts significant anti-inflammatory and analgesic activities. AS1-6 can be used in research on non-steroidal anti-inflammatory agents.

For research use only. We do not sell to patients.

AS1-6

AS1-6 Chemical Structure

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AS1-6 Related Antibodies

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Description

AS1-6 is a selective COX-2 inhibitor with an IC50 of 2.7 μM. AS1-6 has an IC50 of 12.6 μM for COX-1. AS1-6 exerts significant anti-inflammatory and analgesic activities. AS1-6 can be used in research on non-steroidal anti-inflammatory agents[1].

IC50 & Target[1]

COX-2

2.7 μM (IC50)

COX-1

12.6 μM (IC50)

In Vitro

AS1-6 (10-200 μg/mL; 24 h) shows low toxicity to brine shrimp, with an LD50 > 200 μg/mL[1].
AS1-6 (30 μg/mL; 24-48 h) shows no activity against 3T3 fibroblasts, indicating its low toxicity toward non-cancerous cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AS1-6 Related Antibodies
In Vivo

AS1-6 (10 mg/kg; i.p.; single dose) exhibits significant anti-inflammatory activity in the carrageenan-induced paw edema model, analgesic activity in the formalin-induced paw licking model, and significant analgesic activity in the acetic acid-induced writhing model in adult albino mice, and it downregulates the expression of COX-2-related inflammatory mediators[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Albino mice (adult male and female, 6-7 weeks old, 25-30 g)[1]
Dosage: 10 mg/kg
Administration: i.p.; single dose
Result: Significantly reduced paw thickness to 4.00 mm and COX-2 protein levels in the carrageenan-induced paw edema model.
Remarkably suppressed nociceptive behaviors in both the early phase and late phase, indicating both peripheral and central antinociceptive activity in formalin-induced paw licking test.
Significantly decreased the number of writhing responses in the acetic acid-induced writhing test.
Molecular Weight

409.84

Formula

C23H17ClFNO3
SMILES

O=C(NC1=CC=C(F)C=C1)COC2=CC=C(C(/C=C/C3=CC=CC=C3Cl)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AS1-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AS1-6COXCyclooxygenaseCOX-1miceCOX-23T3 fibroblasthuman erythrocytescarrageenanpaw edema modelred blood cellsInhibitorinhibitorinhibit

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