Escholtzine perchlorate 

Escholtzine perchlorate is an Alkaloid. Escholtzine perchlorate can be isolated from Eschscholzia californica. Escholtzine perchlorate is a CYP3A4 inhibitor, 5-HT_1A receptor inhibitor with a CYP3A4 IC₅₀ of 13.4 μM, 5-HT_1A EC₅₀ of 11 μM. Escholtzine perchlorate can be used for the research of anxiety, depression^[1][2].

Escholtzine (60 min) perchlorate weakly inhibits the binding of [³H]8-OH-DPAT to human recombinant 5-HT₁A receptors, with an EC₅₀ of 11 μM and a K_i of 6 μM^[1].
Escholtzine (1 h) perchlorate potently inhibits CYP3A4 enzyme activity in vitro, with an IC₅₀ value of 13.4 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

423.80

C₁₉H₁₈ClNO₈

77790-29-5

Solid

White to off-white

O=Cl(=O)(O)=O.[H][C@]1(N2C)CC3=CC4=C(OCO4)C=C3[C@]2([H])CC5=CC6=C(OCO6)C=C51

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Gafner S, et al. Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro. J Nat Prod. 2006 Mar;69(3):432-5.  [Content Brief]

  [2]. Cahlíková L, et al. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae). Nat Prod Commun. 2010;5(7):1035-1038.  [Content Brief]