Escholtzine

Cat. No.: HY-N16471: Data Sheet
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Escholtzine is an Alkaloid. Escholtzine can be isolated from Eschscholzia californica. Escholtzine is a CYP3A4 inhibitor, 5-HT_1A receptor inhibitor with a CYP3A4 IC₅₀ of 13.4 μM, 5-HT_1A EC₅₀ of 11 μM. Escholtzine can be used for the research of anxiety, depression.

It is advisable to consider the similar product (Escholtzine perchlorate) that retains the same biological activity.

For research use only. We do not sell to patients.

Escholtzine Chemical Structure

CAS No. : 4040-75-9

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This product is a controlled substance and not for sale in your territory.

Other Forms of Escholtzine:

Escholtzine perchlorate Get quote

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•Related Small Molecules:

•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

5-HT_1A Receptor

11 μM (EC₅₀)

CYP3A4

13.4 μg/mL (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	8.709 μM Compound: 3	Antiproliferative activity against human A549 cells after 72 hrs by SRB assay Antiproliferative activity against human A549 cells after 72 hrs by SRB assay	[PMID: 28099003]
CHO	EC₅₀	11 μM Compound: 2	Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells	[PMID: 16562853]
KB	IC₅₀	17.03 μM Compound: 3	Antiproliferative activity against human KB cells after 72 hrs by SRB assay Antiproliferative activity against human KB cells after 72 hrs by SRB assay	[PMID: 28099003]
MCF7	IC₅₀	26.56 μM Compound: 3	Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 28099003]
MDA-MB-231	IC₅₀	26.13 μM Compound: 3	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay	[PMID: 28099003]

In Vitro

Escholtzine (60 min) weakly inhibits the binding of [³H]8-OH-DPAT to human recombinant 5-HT₁A receptors, with an EC₅₀ of 11 μM and a K_i of 6 μM^[1].
Escholtzine (1 h) potently inhibits CYP3A4 enzyme activity in vitro, with an IC₅₀ value of 13.4 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

323.34

Formula

C₁₉H₁₇NO₄

CAS No.

4040-75-9

Appearance

Solid

Color

White to off-white

SMILES

[H][C@]1(N2C)CC3=CC4=C(OCO4)C=C3[C@]2([H])CC5=CC6=C(OCO6)C=C51

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Data Sheet (271 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Gafner S, et al. Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro. J Nat Prod. 2006 Mar;69(3):432-5. [Content Brief]

[2]. Cahlíková L, et al. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae). Nat Prod Commun. 2010;5(7):1035-1038. [Content Brief]

Escholtzine Related Classifications

Neurological Disease

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Escholtzine4040-75-95-HT ReceptorCytochrome P450Serotonin Receptor5-hydroxytryptamine ReceptorCYPsAlkaloidEschscholzia californica5-HT_1ACYP3A4neurological diseaseanxietyInhibitorinhibitorinhibit

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