Tetrachloroauric acid
Based on 1 publication(s) in Google Scholar
Tetrachloroauric acid is an Au (III) compound and bilayer disruptor that can be used to damage red blood cells. Tetrachloroauric acid specifically disrupts the bilayer structure of representative phospholipids (dimyristoylphosphatidylcholine and dimyristoylphosphatidylethanolamine) in human red blood cell membranes, and induces morphological changes in intact human red blood cells. Tetrachloroauric acid causes downregulation of MT I-II and GFAP expression in the mouse brain following chronic treatment. Tetrachloroauric acid is being used in studies related to neurotoxicity and hematotoxicity, including analyses of human red blood cells and molecular models of red blood cell membranes, as well as immunohistochemical evaluation of the mouse brain.
For research use only. We do not sell to patients.
- Purity: 97%
- CAS No.: 16903-35-8
- Formula: HAuCl4
- Molecular Weight:339.79
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications Citing Use of MedChemExpress (MCE) Tetrachloroauric acid
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Biological Activity
Tetrachloroauric acid (0.01-10 mM) induces concentration-dependent structural perturbations in DMPC multibilayers, disrupting bilayer structure at 0.1-3 mM and promoting reordering at 5-10 mM[1].
Tetrachloroauric acid (0.01-10 mM) induces mild, concentration-dependent structural perturbation in DMPE multibilayers, with less disruption than observed in DMPC multibilayers[1].
Tetrachloroauric acid (0.01-0.1 mM; 18 °C, 37 °C) increases lipid packing order at the polar headgroup and acyl chain regions of DMPC LUVs at 18 °C and 37 °C, with a more pronounced effect at 37 °C[1].
Tetrachloroauric acid (0.01-0.1 mM; 37 °C) induces non-monotonic changes in lipid packing order in isolated unsealed human erythrocyte membranes at 37 °C, with distinct minima and maxima at specific concentrations[1].
Tetrachloroauric acid (0.01-0.1 mM; 18 °C, 37 °C) reduces DPH fluorescence lifetime (indicating increased interchain hydration) and increases rotational correlation time (indicating reduced rotational diffusion) in DMPC LUVs at 18 °C and 37 °C, with concentration-dependent response kinetics[1].
Tetrachloroauric acid (0.01-0.07 mM; 37 °C) induces minor, non-monotonic changes in DPH fluorescence lifetime and rotational correlation time in isolated unsealed human erythrocyte membranes at 37 °C, indicating milder effects than in DMPC LUVs[1].
Tetrachloroauric acid (0.1-10 mM) induces concentration-dependent morphological changes in intact human erythrocytes, transitioning from stomatocytes/spherostomatocytes at low concentrations to elliptocytes/knizocytes at high concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 16903-35-8
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Appearance Solid
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Molecular Weight 339.79
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Formula HAuCl4
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Color Yellow to orange
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SMILES
Cl[AuH](Cl)(Cl)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Metabolism-Driven Colorimetric "Read-to-Answer" Sensor Array for Bacterial Discrimination and Antimicrobial Susceptibility Testing. [Abstract]2025 Aug 12;97(31):17040-17049. PMID: 40737437
Solvent & Solubility
DMSO : 200 mg/mL (588.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (785 KB)
- English - EN (785 KB)
- Français - FR (785 KB)
- Deutsch - DE (785 KB)
- Norwegian - NO (785 KB)
- Español - ES (785 KB)
- Swedish - SV (785 KB)
- Italian - IT (785 KB)
- Portuguese - PT (785 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9430 mL | 14.7150 mL | 29.4299 mL | 73.5749 mL |
| 5 mM | 0.5886 mL | 2.9430 mL | 5.8860 mL | 14.7150 mL | |
| 10 mM | 0.2943 mL | 1.4715 mL | 2.9430 mL | 7.3575 mL | |
| 15 mM | 0.1962 mL | 0.9810 mL | 1.9620 mL | 4.9050 mL | |
| 20 mM | 0.1471 mL | 0.7357 mL | 1.4715 mL | 3.6787 mL | |
| 25 mM | 0.1177 mL | 0.5886 mL | 1.1772 mL | 2.9430 mL | |
| 30 mM | 0.0981 mL | 0.4905 mL | 0.9810 mL | 2.4525 mL | |
| 40 mM | 0.0736 mL | 0.3679 mL | 0.7357 mL | 1.8394 mL | |
| 50 mM | 0.0589 mL | 0.2943 mL | 0.5886 mL | 1.4715 mL | |
| 60 mM | 0.0490 mL | 0.2452 mL | 0.4905 mL | 1.2262 mL | |
| 80 mM | 0.0368 mL | 0.1839 mL | 0.3679 mL | 0.9197 mL | |
| 100 mM | 0.0294 mL | 0.1471 mL | 0.2943 mL | 0.7357 mL |