Antiviral agent 87 

Antiviral agent 87 is a potent antiviral agent with low cytotoxicity in host cells. Antiviral agent 87 stabilizes prefusion HA conformation, blocks viral membrane fusion and host cell entry, and inhibits entry and replication of diverse influenza A virus subtypes. Antiviral agent 87 can be used for the research of influenza A virus infection^[1].

Antiviral agent 87 (compound 1) (0-125 nM; 2 h) inhibits replication of WSN-PB2-Nanoluc influenza virus in HCT116 cells in a dose-dependent manner, with an IC₅₀ of 16.79 nM^[1].
Antiviral agent 87 potently inhibits replication of A/WSN/33 (H1N1) influenza virus in A549 cells with an IC₅₀ of 0.040 μM and exhibits no cytotoxicity at concentrations up to 25 μM, yielding a selectivity index >625^[1].
Antiviral agent 87 (25 μM; 24-48 h) inhibits replication of diverse influenza A virus subtypes (H1N1, H5N1, H3N2) in A549 cells^[1].
Antiviral agent 87 (8 h) inhibits entry of A/WSN/33 influenza virus into A549 cells^[1].
Antiviral agent 87 (0.08-5 μM; 30 min) inhibits influenza virus-mediated membrane fusion and hemolysis of chicken erythrocytes^[1].
Antiviral agent 87 (0.5-1 μM; 48 h) reduces levels of A/WSN/33 influenza virus M, HA, and NS mRNAs in A549 cells without affecting cellular RNA levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

344.26

C₁₅H₁₅Cl₂NO₂S

346715-10-4

O=S(C1=CC(Cl)=CC=C1Cl)(N(CC)C2=C(C)C=CC=C2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. White K, et al. Aryl Sulfonamide Inhibits Entry and Replication of Diverse Influenza Viruses via the Hemagglutinin Protein. J Med Chem. 2021;64(15):10951-10966.