Antiviral agent 87
Antiviral agent 87 is a potent antiviral agent with low cytotoxicity in host cells. Antiviral agent 87 stabilizes prefusion HA conformation, blocks viral membrane fusion and host cell entry, and inhibits entry and replication of diverse influenza A virus subtypes. Antiviral agent 87 can be used for the research of influenza A virus infection.
For research use only. We do not sell to patients.
- CAS No.: 346715-10-4
- Formula: C15H15Cl2NO2S
- Molecular Weight:344.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
25 μM
Compound: 1
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Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
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[PMID: 34260245] |
Antiviral agent 87 (compound 1) (0-125 nM; 2 h) inhibits replication of WSN-PB2-Nanoluc influenza virus in HCT116 cells in a dose-dependent manner, with an IC50 of 16.79 nM[1].
Antiviral agent 87 potently inhibits replication of A/WSN/33 (H1N1) influenza virus in A549 cells with an IC50 of 0.040 μM and exhibits no cytotoxicity at concentrations up to 25 μM, yielding a selectivity index >625[1].
Antiviral agent 87 (25 μM; 24-48 h) inhibits replication of diverse influenza A virus subtypes (H1N1, H5N1, H3N2) in A549 cells[1].
Antiviral agent 87 (8 h) inhibits entry of A/WSN/33 influenza virus into A549 cells[1].
Antiviral agent 87 (0.08-5 μM; 30 min) inhibits influenza virus-mediated membrane fusion and hemolysis of chicken erythrocytes[1].
Antiviral agent 87 (0.5-1 μM; 48 h) reduces levels of A/WSN/33 influenza virus M, HA, and NS mRNAs in A549 cells without affecting cellular RNA levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:0.5; 1 μM
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Incubation Time:48 h
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Result:Decreased HA, NS1, M1, and M2 mRNA levels of A/WSN/33 (H1N1) influenza virus in A549 cells.
Chemical Information
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CAS No. 346715-10-4
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Molecular Weight 344.26
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Formula C15H15Cl2NO2S
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SMILES
O=S(C1=CC(Cl)=CC=C1Cl)(N(CC)C2=C(C)C=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiviral agent 87 Related Classifications
HY-183929 Related Classifications
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- Antiviral agent 87
- 346715-10-4
- Antiviral agent87
- Antiviral agent-87
- Influenza Virus
- A549 cells
- A/WSN/33 (H1N1) influenza virus
- chicken erythrocytes
- influenza A virus subtypes
- WSN-PB2-Nanoluc influenza virus
- H5N1
- H3N2
- host cells
- primary human bronchial epithelial cells
- influenza virus hemagglutinin protein
- Inhibitor
- inhibitor
- inhibit