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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
260 Results for "
transmembrane receptor
" in MedChemExpress (MCE) Product Catalog:
Products (260)
260 Results for "transmembrane receptor" in MCE Product Catalog:
5
Category:
Natural Products Other disease Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
3
3 Cited Publications
NBI-27914 is a highly selective, high-affinity non-peptide competitive antagonist of human corticotropin-releasing factor receptor 1 (CRFR1). NBI-27914 primarily binds to the His199 and Met276 sites in the transmembrane domain of the receptor .
3
3 Cited Publications
Cat. No.: HY-P70147
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; transmembrane receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular Endothelial Cell Growth Factor 165 receptor
Species:
Human
Source:
HEK293
2
2 Cited Publications
Target:
Research Areas:
Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .
2
2 Cited Publications
F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM). Frizzled receptors (FZDs) influence Wnt signaling, mediating embryonic development and tissue homeostasis. F7H is a potent ligand for the FZD7 transmembrane domain (TMD) .
2
2 Cited Publications
Cat. No.: HY-P700468
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GLP1R; GLP-1-R; Glucagon Like Peptide 1 receptor; Seven transmembrane Helix receptor; Glucagon-Like Peptide 1 receptor; GLP1 receptor; GLP-1R; GLP-1; GLP-1 receptor
Species:
Human
Source:
HEK293
2
Taladegib is a Smoothened (SMO) antagonist. Taladegib hydrochloride inhibits the Hedgehog signaling pathway, with an IC50 of 5.5 nM for suppressing GLI1 mRNA expression in DAOY cells and an IC50 of 7.6 nM in CGNP cell proliferation assays. Taladegib binds to the extracellular loop region (site 1) of the transmembrane domain of the SMO receptor, competes with cyclopamine for SMO binding, and thereby inhibits Gli-dependent transcription. Taladegib can be used in studies of Hedgehog pathway-related cancers .
2
2 Cited Publications
Cat. No.: HY-N0247
CAS No.: 58558-08-0
Category:
Umbelliferae Extract Plants Disease Research Fields Saccharides Cancer Carphephorus corymbosus (Nutt.) Torr. & A.Gray Monosaccharides
Target:
2
Taladegib (LY2940680) hydrochloride is a Smoothened (SMO) antagonist. Taladegib hydrochloride inhibits the Hedgehog signaling pathway, with an IC50 of 5.5 nM for suppressing GLI1 mRNA expression in DAOY cells and an IC50 of 7.6 nM in CGNP cell proliferation assays. Taladegib hydrochloride binds to the extracellular loop region (site 1) of the transmembrane domain of the SMO receptor, competes with cyclopamine for SMO binding, and thereby inhibits Gli-dependent transcription. Taladegib hydrochloride can be used in studies of Hedgehog pathway-related cancers .
2
2 Cited Publications
Cat. No.: HY-P7151
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL16; CXCLG16; C-X-C Motif Chemokine Ligand 16; Scavenger receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein; SR-PSOX; Chemokine (C-X-C Motif) Ligand 16; SRPSOX; Small-Inducible Cytokine B16; transmembrane Chemokine CXCL16; CXC Chemokine Ligand 16; C-X-C Motif Chemokine 16; SCYB16
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P3496
CAS No.: 1322711-38-5
Target:
Research Areas:
1
1 Cited Publications
Target:
Research Areas:
AMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects .
1
1 Cited Publications
Target:
Research Areas:
AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects .
1
1 Cited Publications
Cat. No.: HY-P72206
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GLP1R; GLP-1-R; Glucagon Like Peptide 1 receptor; Seven transmembrane Helix receptor; Glucagon-Like Peptide 1 receptor; GLP1 receptor; GLP-1R; GLP-1; GLP-1 receptor
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P9976
CAS No.: 1461640-62-9
Synonyms: ch38SB19; hu38SB19; SAR-650984
1
1 Cited Publications
Cat. No.: HY-P72434
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF12A; Tumor Necrosis Factor receptor Superfamily Member 12A; TNF receptor Superfamily Member 12A; FGF-Inducible 14; TweakR; Tweak-receptor; FN14; Tumor Necrosis Factor receptor Superfamily, Member 12A; CD266; Type I transmembrane Protein Fn14; Fibrob
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P9976A
CAS No.: 1461640-62-9
1
1 Cited Publications
Cat. No.: HY-P70601
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGRT; Major Histocompatibility Complex Class I-Like Fc receptor; Fc Gamma receptor And Transporter; Neonatal Crystallizable Fc receptor FcRn Splice Variant 6; Neonatal Fc receptor; Neonatal Crystallizable Fc receptor FcRn Splice Variant 5; FcRn; Neonatal Fragment Crystallizable Fc receptor FcRn; IgG Fc Fragment receptor Transporter Alpha Chain; Immunoglobulin receptor, Intestinal, Heavy Chain; IgG receptor FcRn Large Subunit P51; Neonatal Fc-receptor For Ig; FcgammaRn; FCRN Alpha-Chain; Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc receptor; FcRn Alpha Chain; transmembrane Alpha Chain Of The Neonatal receptor; Alpha-Chain; Fc Fragment Of IgG, receptor, Transporter, Alpha; FCRN; Fc Fragment Of IgG receptor And Transporter; B2M; Beta 2-Microglobulin; Beta-2-Microglobulin; Beta-2-Microglobin; Beta Chain Of MHC Class I Molecules; AMYLD6; Beta 2-Microglobulin Protein; MHC1D4; Human Nkt Tcr Alpha Chain; IMD43; Human Nkt Tcr Beta Chain
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P72961
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL16; CXCLG16; C-X-C Motif Chemokine Ligand 16; Scavenger receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein; SR-PSOX; Chemokine (C-X-C Motif) Ligand 16; SRPSOX; Small-Inducible Cytokine B16; transmembrane Chemokine CXCL16; CXC Chemoki
Species:
Human
Source:
HEK293
Cat. No.: HY-153213
CAS No.: 1421683-12-6
Target:
Research Areas:
Org 274179-0 is a low-molecular-weight allosteric thyrotropin receptor (TSH Receptor) antagonist with equipotent follicle-stimulating hormone receptor antagonistic activity and selectivity for the luteinizing hormone receptor. Org 274179-0 binds to the transmembrane domain of the thyrotropin receptor, stabilizes the receptor's inactive state, and blocks agonist-induced and constitutive signaling through the adenylyl cyclase/cAMP and phospholipase C pathways. Org 274179-0 can be used for research on Graves' disease and Graves' ophthalmopathy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
