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Isatuximab

(Synonyms: ch38SB19; hu38SB19; SAR-650984)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions.

For research use only. We do not sell to patients.

  • Purity: 98.5%
  • CAS No.: 1461640-62-9
  • Molecular Weight:145.2 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Isatuximab
  • Experimental Validation Results for Isatuximab
  • Experimental Validation Results for Isatuximab
  • Isatuximab Chemical Structure
    Isatuximab Chemical Structure
CAS No.: 1461640-62-9
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized CD38 Protein, Human can bind Isatuximab. The EC50 for this effect is 6.163 ng/mL.

  • 1/16

    Flow Cytometry analysis of Raji cells labelling CD38 (red) with Isatuximab (anti-CD38) (HY-P9976). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.

  • Isatuximab Chemical Structure
    1/16
  • Isatuximab
  • Immobilized CD38 Protein, Human can bind Isatuximab. The EC50 for this effect is 6.163 ng/mL.
  • Flow Cytometry analysis of Raji cells labelling CD38 (red) with Isatuximab (anti-CD38) (HY-P9976). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.