CD97 Antibody (YA1144)
(Synonyms: ADGRE5; Adhesion G protein-coupled receptor E5; CD97 antigen; Leukocyte antigen CD97; Seven span transmembrane protein; TM7LN1)CD97 Antibody (YA1144) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD97.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.145.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
CD97 Antibody (YA1144) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD97.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 92 kDa
A synthesized peptide derived from human CD97
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.145.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD97 receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Secreted, extracellular space
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Expression
Tissue_specificity:CD97 is widely expressed in most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Smooth muscle cells also express CD97 in large quantities. Furthermore, CD97 is expressed in thyroid cancer, colorectal cancer, gastric cancer, esophageal cancer, and pancreatic cancer. CD97 expression is increased under the inflammatory conditions of the central nervous system in multiple sclerosis and in the synovial tissue of rheumatoid arthritis. Increased CD97 expression in the synovium is accompanied by elevated levels of detectable soluble CD97 in the synovial fluid.
Induction:Rapid up-regulation during lymphocyte activation -
Isoforms & Post-Translational Modification
P48960 has 3 isomers: P48960-1: 91869 Da (predicted); P48960-2: 81743 Da (predicted); P48960-3: 86628 Da (predicted).
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit -
Subunit
Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate
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SwissProt ID
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Synonyms
ADGRE5; Adhesion G protein-coupled receptor E5; CD97 antigen; Leukocyte antigen CD97; Seven span transmembrane protein; TM7LN1
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Research Field
Neuroscience
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