ADGRE5 - adhesion G protein-coupled receptor E5 Gene

Homo sapiens

Also known as CD97; TM7LN1

Gene ID: 976 | Gene type: protein coding

About ADGRE5

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,381,144-14,408,725 (from NCBI)

This gene has 16 transcripts (splice variants), 204 orthologues and 42 paralogues. Broad expression in bone marrow (RPKM 63.9), spleen (RPKM 54.1) and 23 other tissues.

Summary

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of Cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

ADGRE5 Products(3)

mRNA	Protein	Name
NM_001025160.3	NP_001020331.1	adhesion G protein-coupled receptor E5 isoform 3 preproprotein
NM_001784.5	NP_001775.2	adhesion G protein-coupled receptor E5 isoform 2 preproprotein
NM_078481.4	NP_510966.1	adhesion G protein-coupled receptor E5 isoform 1 preproprotein

ADGRE5 Protein Structure

EGF_CA

GPS

7tm_2

0
200
400
600
835 a.a.

Protein Preferred Names

Protein Names

adhesion G protein-coupled receptor E5

CD97 molecule

Recombinant ADGRE5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75369	CD97 Protein, Human (HEK293, His)	P48960-2/NP_001775.2 (Q21-Q398)	≥95%
HY-P75370	CD97 Protein, Human (HEK293, hFc)	P48960/NP_001775 (Q21-Q398)	≥95%

Related Diseases

Diseases

Alias

Vibratory Urticaria

Vibratory Angioedema	Dermodistortive Urticaria
VBU	Ddu
Angioedema, Vibratory

Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma	Anaplastic Thyroid Cancer
Thyroid Cancer, Anaplastic	Thyroid Carcinoma, Anaplastic
Thyroid Carcinoma Anaplastic

Reactive Arthritis

Postdysenteric Arthropathy	Reiter Disease
Pira	Reiter Syndrome
Reiters Syndrome	Arthritis, Reactive
Fiessinger Leroy Reiter Syndrome	Post-Bacterial Arthropathy
Reiter'S Disease	Post-Infectious Arthritis
Post-Infectious Reactive Arthropathy	Reiter'S Syndrome
Arthritis Urethritica	Fiessinger-Leroy Disease
Polyarthritis Enterica	Venereal Arthritis
Arthritis Reactive	Post-Dysenteric Arthropathy
Arthritis, Venereal

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Physical Urticaria

Symptomatic Dermographism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00351	ADGRE5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADGRE5	MGD	MGI:1347095
Macaca mulatta	ADGRE5	VGNC	VGNC:69441
Canis familiaris	ADGRE5	VGNC	VGNC:37637
Felis catus	ADGRE5	VGNC	VGNC:82335
Rattus norvegicus	ADGRE5	RGD	RGD:1305595
Bos taurus	ADGRE5	VGNC	VGNC:55196
Others	ADGRE5	NCBI

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