ADGRE5 - adhesion G protein-coupled receptor E5 Gene

Also Known as CD97; TM7LN1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 976

About ADGRE5

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,381,144-14,408,725 (from NCBI)

This gene has 16 transcripts (splice variants), 204 orthologues and 42 paralogues. Broad expression in bone marrow (RPKM 63.9), spleen (RPKM 54.1) and 23 other tissues.

Summary

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of Cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with Other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

ADGRE5 Products (3)

mRNA Protein Name
NM_001025160.3 NP_001020331.1 adhesion G protein-coupled receptor E5 isoform 3 preproprotein
NM_001784.5 NP_001775.2 adhesion G protein-coupled receptor E5 isoform 2 preproprotein
NM_078481.4 NP_510966.1 adhesion G protein-coupled receptor E5 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9064337 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRE5 Protein Structure

EGF_CA

EGF_CA: Calcium-binding EGF domain (64 - 114)

EGF_CA

EGF_CA: Calcium-binding EGF domain (116 - 158)

EGF_CA

EGF_CA: Calcium-binding EGF domain (160 - 207)

EGF_CA

EGF_CA: Calcium-binding EGF domain (209 - 256)

GPS

GPS: GPCR proteolysis site, GPS, motif (493 - 537)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (546 - 781)

  • 0
  • 200
  • 400
  • 600
  • 835 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor E5

  • CD97 molecule

Recombinant ADGRE5 Proteins

Cat. No. Product Name Accession Purity
HY-P75369 CD97 Protein, Human (HEK293, His) P48960-2/NP_001775.2 (Q21-Q398) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75370 CD97 Protein, Human (HEK293, hFc) P48960-2/NP_001775.2 (Q21-Q398) ≥ 90%, as determined by reducing SDS-PAGE.

ADGRE5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81399 CD97 Antibody (YA1144) IHC-P Human
HY-P81399A CD97 Antibody (YA1144)(PBS only) IHC-P Human
HY-P84353 CD97 Antibody (YA4050) IHC-P, FC, ELISA Human
HY-P84353A CD97 Antibody (YA4050)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Vibratory Urticaria

  • Vibratory Angioedema

  • Dermodistortive Urticaria

  • VBU

  • Ddu

  • Angioedema, Vibratory
Thyroid Gland Anaplastic Carcinoma

  • Anaplastic Thyroid Carcinoma

  • Anaplastic Thyroid Cancer

  • Thyroid Cancer, Anaplastic

  • Thyroid Carcinoma, Anaplastic

  • Thyroid Carcinoma Anaplastic
Reactive Arthritis

  • Postdysenteric Arthropathy

  • Reiter Disease

  • Pira

  • Reiter Syndrome

  • Reiters Syndrome

  • Arthritis, Reactive

  • Fiessinger Leroy Reiter Syndrome

  • Post-Bacterial Arthropathy

  • Reiter'S Disease

  • Post-Infectious Arthritis

  • Post-Infectious Reactive Arthropathy

  • Reiter'S Syndrome

  • Arthritis Urethritica

  • Fiessinger-Leroy Disease

  • Polyarthritis Enterica

  • Venereal Arthritis

  • Arthritis Reactive

  • Post-Dysenteric Arthropathy

  • Arthritis, Venereal
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Physical Urticaria

  • Symptomatic Dermographism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00351 ADGRE5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18693 Adgre5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25180 Adgre5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADGRE5 MGD MGI:1347095
Macaca mulatta ADGRE5 VGNC VGNC:69441
Canis familiaris ADGRE5 VGNC VGNC:37637
Felis catus ADGRE5 VGNC VGNC:82335
Rattus norvegicus ADGRE5 RGD RGD:1305595
Bos taurus ADGRE5 VGNC VGNC:55196
Others ADGRE5 NCBI