CD97 Antibody (YA4050)

Cat. No.: HY-P84353: Data Sheet User Guide for Antibodies
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CD97 Antibody (YA4050) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD97.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CD97 Antibody (YA4050) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD97.

Host

Mouse

Clonality

Monoclonal Antibody

Molecular Weight

Predicted band size: 91.8 kDa;

Observed band size: 75 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P48960

Gene ID

976 [NCBI]

Immunogen

Purified recombinant fragment of human CD97 (AA: extra 419-552) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Secreted, extracellular space

Expression：
Tissue_specificity:CD97 is widely expressed in most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Smooth muscle cells also express CD97 in large quantities. Furthermore, CD97 is expressed in thyroid cancer, colorectal cancer, gastric cancer, esophageal cancer, and pancreatic cancer. CD97 expression is increased under the inflammatory conditions of the central nervous system in multiple sclerosis and in the synovial tissue of rheumatoid arthritis. Increased CD97 expression in the synovium is accompanied by elevated levels of detectable soluble CD97 in the synovial fluid.

Induction:Rapid up-regulation during lymphocyte activation

Isoforms & Post-Translational Modification：P48960 has 3 isomers: P48960-1: 91869 Da (predicted); P48960-2: 81743 Da (predicted); P48960-3: 86628 Da (predicted).
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit

Subunit：Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate

Synonyms

ADGRE5; TM7LN1

Documentation

User Guide for Antibodies (1077 KB)