GSK575594A
GSK575594A is a modulator of the nicotinic acetylcholine receptor (nAChR) in Ascaris suum. GSK575594A enhances muscle contractions induced by acetylcholine (ACh) by binding to the allosteric binding site between subunits within the transmembrane domain of nAChR. At a concentration of 3 μM, GSK575594A significantly increased the contraction induced by ACh in Ascaris suum (Emax increased from 1.19 g to 1.51 g). GSK575594A may be used in research within the field of antiparasitic studies.
For research use only. We do not sell to patients.
- CAS No.: 909418-68-4
- Formula: C24H23F2N3O3S
- Molecular Weight:471.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
10 μM
Compound: GSK575594A
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Inhibition of GlyT1 (unknown origin) expressed in HEK293 cells by scintillation proximity assay
Inhibition of GlyT1 (unknown origin) expressed in HEK293 cells by scintillation proximity assay
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[PMID: 26575458] |
Chemical Information
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CAS No. 909418-68-4
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Molecular Weight 471.52
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Formula C24H23F2N3O3S
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SMILES
O=C(N1CCN(C2=CC=C(N)C=C2F)CC1)C3=CC(S(=O)(C)=O)=CC=C3C4=CC=C(F)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK575594A Related Classifications
HY-111161 Related Classifications
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